Three Undescribed Furanoditerpenoids from the Tinospora crispa that Inhibit NO Production

Abstract

Phytochemical study on the methanol extract of the stems of Tinospora crispa (L.) Hook.f. & Thomson led to the isolation of thirteen compounds including three undescribed cis‐clerodane‐type furanoditerpenoids (1‐3) and ten known ones (4‐13). Their chemical structures were determined by IR, HR‐ESI‐MS, 1D‐, and 2D‐NMR spectra. Compounds 2‐6 and 8 inhibited moderately NO production in LPS activated RAW 264.7 cell with the IC50 values of 83.5, 57.6, 75.3, 78.1, and 74.7 µM, respectively.