We report on the first layered deuterium-tritium (DT) capsule implosions indirectly driven by a "highfoot" laser pulse that were fielded in depleted uranium hohlraums at the National Ignition Facility. Recently, high-foot implosions have demonstrated improved resistance to ablation-front Rayleigh-Taylor instability induced mixing of ablator material into the DT hot spot [Hurricane et al., Nature (London) 506, 343 (2014)]. Uranium hohlraums provide a higher albedo and thus an increased drive equivalent to an additional 25 TW laser power at the peak of the drive compared to standard gold hohlraums leading to higher implosion velocity. Additionally, we observe an improved hot-spot shape closer to round which indicates enhanced drive from the waist. In contrast to findings in the National Ignition Campaign, now all of our highest performing experiments have been done in uranium hohlraums and achieved total yields approaching 10 16 neutrons where more than 50% of the yield was due to additional heating of alpha particles stopping in the DT fuel. In indirect-drive inertial confinement fusion (ICF) [1,2], laser energy, converted to thermal x rays inside a high-Z cavity (hohlraum), ablatively drives the implosion of a spherical capsule containing a deuterium-tritium (DT) fuel layer. A high-velocity, low-entropy, highly symmetric implosion is required to form a hot spot of sufficiently high density and temperature from a combination of PdV work and alpha particle deposition. Above the ignition threshold, a self-sustained nuclear burn wave is launched igniting the surrounding compressed fuel layer. Ignition and burn is predicted for stagnation pressures above 300 Gbar [3].Experiments during the National Ignition Campaign (NIC) [4] demonstrated high implosion velocities (∼360 km=s) [5], and high areal mass densities of 1.3 AE 0.1 g=cm 2 [6], which were predicted to be sufficient to reach ignition [7]. However, some of them showed evidence for significant amounts of CH ablator material mixing into the hot spot [8,9], degrading the implosion performance. To increase the resistance to hydrodynamic instabilities [10], the "high-foot" drive design was developed [11,12], which has demonstrated an order-of-magnitude improvement in neutron yields with first evidence for additional heating from alpha particle stopping [13]. The high-foot drive raises the hohlraum temperature to 90 eV during the foot, launching a stronger first shock and sets the implosion on a higher adiabat. Among the benefits are a larger ablator density scale length (reducing susceptibility to ablation front RayleighTaylor growth [14]), and a shorter, simplified laser drive (three shocks rather than four). These benefits come at the price of lower fuel areal density, which requires higher implosion velocity compared to the low-entropy design [7] to achieve ignition.The first high-foot DT implosions [12,13,15] were done in gold (Au) hohlraums. These experiments incrementally increased laser peak power P laser and thus total laser energy from 351 TW=1.3 MJ on N13...