Three-way interactions between mosquito population, viral strain and temperature underlying chikungunya virus transmission potential

Zouache, Karima; Fontaine, Albin; Vega-Rúa, Anubis; Mousson, Laurence; Thiberge, Jean‐Michel; Lourenço‐de‐Oliveira, Ricardo; Caro, Valérie; Lambrechts, Louis; Failloux, Anna‐Bella

doi:10.1098/rspb.2014.1078

Cited by 149 publications

(161 citation statements)

References 49 publications

(88 reference statements)

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“…When A. albopictus transmission potential for CHIKV was measured in 6 worldwide vector populations, with 2 virus strains and in 2 ambient temperatures (20°and 28°C), strong effects of the 3-way interaction of mosquito population, virus strain, and temperature were observed. This highlights the importance of studies that focus on genotype by genotype by environment interactions [43]. Differences in transmission efficiency of CHIKV by A. aegypti and A. albopictus were noted in populations of both species from the Americas, while dissemination rates were similar.…”

Section: Vector Competencementioning

confidence: 88%

Invasiveness ofAedes aegyptiandAedes albopictusand Vectorial Capacity for Chikungunya Virus

2016

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In this review, we highlight biological characteristics of Aedes aegypti and Aedes albopictus, 2 invasive mosquito species and primary vectors of chikungunya virus (CHIKV), that set the tone of these species' invasiveness, vector competence, and vectorial capacity (VC). The invasiveness of both species, as well as their public health threats as vectors, is enhanced by preference for human blood. Vector competence, characterized by the efficiency of an ingested arbovirus to replicate and become infectious in the mosquito, depends largely on vector and virus genetics, and most A. aegypti and A. albopictus populations thus far tested confer vector competence for CHIKV. VC, an entomological analog of the pathogen's basic reproductive rate (R 0 ), is epidemiologically more important than vector competence but less frequently measured, owing to challenges in obtaining valid estimates of parameters such as vector survivorship and host feeding rates. Understanding the complexities of these factors will be pivotal in curbing CHIKV transmission.

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Section: Vector Competencementioning

confidence: 88%

Invasiveness ofAedes aegyptiandAedes albopictusand Vectorial Capacity for Chikungunya Virus

2016

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“…The GÂG principle was extended to integrate the interplay of environmental factors resulting in GÂGÂE (genotypeby-genotype-by-environment) [118,119]. Temperature is one of the best-studied factors affecting HT competency.…”

Section: Temperaturementioning

confidence: 99%

Rift Valley fever virus: strategies for maintenance, survival and vertical transmission in mosquitoes

Lumley

Horton

Hernandez-Triana

et al. 2017

Journal of General Virology

101

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Rift Valley fever virus (RVFV) is a mosquito-borne arbovirus causing severe disease in humans and ruminants. Spread of RVFV out of Africa has raised concerns that it could emerge in Europe or the USA. Virus persistence is dependent on successful infection of, replication in, and transmission to susceptible vertebrate and invertebrate hosts, modulated by virushost and vector-virus interactions. The principal accepted theory for the long-term maintenance of RVFV involves vertical transmission (VT) of virus to mosquito progeny, with the virus surviving long inter-epizootic periods within the egg. This VT hypothesis, however, is yet to be comprehensively proven. Here, evidence for and against the VT of RVFV is reviewed along with the identification of factors limiting its detection in natural and experimental data. The observations of VT for other arboviruses in the genera Alphavirus, Flavivirus and Orthobunyavirus are discussed within the context of RVFV. The review concludes that VT of RVFV is likely but that current data are insufficient to irrefutably prove this hypothesis.

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“…The study demonstrated that these sources of variation do not necessarily act independently and may interact with each other (mosquito genotype × virus genotype × environment) to determine the outcome of VC. 60 To accurately assess the impact and plasticity of Wolbachia-mediated DENV blocking, it is also necessary to take this G × G × E interaction into consideration.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Temperature on Wolbachia-Mediated Dengue Virus Blocking in Aedes aegypti

Ye¹,

Carrasco²,

Dong³

et al. 2016

The American Society of Tropical Medicine and Hygiene

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Abstract. Dengue fever, caused by dengue virus (DENV), is endemic in more than 100 countries. The lack of effective treatment of patients and the suboptimal efficacies of the tetravalent vaccine in trials highlight the urgent need to develop alternative strategies to lessen the burden of dengue fever. Wolbachia pipientis, an obligate intracellular bacterium, is being developed as a biocontrol strategy against dengue because it limits the replication of the DENV in the mosquito vector, Aedes aegypti. However, several recent studies have demonstrated the sensitivity of pathogens, vectors, and their symbionts to temperature. To understand how the tripartite interactions between the mosquito, DENV, and Wolbachia may change under different temperature regimes, we assessed the vector competence and transmission potential of DENV-infected mosquitoes reared at a common laboratory setting of a constant 25°C and at two diurnal temperature settings with mean of 25°C and 28°C and a fluctuating range of 8°C (±4°C). Temperature significantly affected DENV infection rate in the mosquitoes. Furthermore, temperature significantly influenced the proportion of mosquitoes that achieved transmission potential as measured by the presence of virus in the saliva. Regardless of the temperature regimes, Wolbachia significantly and efficiently reduced the proportion of mosquitoes achieving infection and transmission potential across all the temperature regimes studied. This work reinforces the robustness of the Wolbachia biocontrol strategy to field conditions in Cairns, Australia, and suggests that similar studies are required for local mosquito genotypes and field relevant temperatures for emerging field release sites globally.

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Three-way interactions between mosquito population, viral strain and temperature underlying chikungunya virus transmission potential

Cited by 149 publications

References 49 publications

Invasiveness ofAedes aegyptiandAedes albopictusand Vectorial Capacity for Chikungunya Virus

Invasiveness ofAedes aegyptiandAedes albopictusand Vectorial Capacity for Chikungunya Virus

Rift Valley fever virus: strategies for maintenance, survival and vertical transmission in mosquitoes

The Effect of Temperature on Wolbachia-Mediated Dengue Virus Blocking in Aedes aegypti

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