Three-Year Follow-Up Study in Patients with Guillain-Barré Syndrome

Martić, Vesna; Božović, Ivo; Berisavac, Ivana; Basta, Ivana; Perić, Stojan; Babic, Milica; Rajić, Sonja; Bjelica, Bogdan; Tamaš, Olivera; Stojanov, Aleksandar; Grunauer, Marija; Cobeljic, Mina; Komatina, Nenad; Djuric, Vanja; Petrovic, M.; Vujovic, Balsa; Kovacevic, Aleksandra Dominovic; Djordjević, Gordana; Jovanović, Dejana; Stević, Zorica

doi:10.1017/cjn.2018.12

Cited by 11 publications

(9 citation statements)

References 37 publications

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“…Among all the patients included in our study, males were more affected. This was the same as in other studies, in which males accounted for over 50% of all the cases 5,22,23 . Our cases had a median age of 44 years, which was close to the average of some other studies, which ranged from 40 to 50 years 15,24 .…”

Section: Discussionsupporting

confidence: 90%

Clinical-epidemiological characteristics associated with discharge outcomes and seasonality among surviving patients with Guillain-Barré syndrome in a national third-level hospital, Lima, Peru

Velásquez-Rimachi

López-Saavedra

Rodriguez-López

et al. 2021

Arq. Neuro-Psiquiatr.

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Background: Guillain-Barré syndrome (GBS) is an autoimmune disease that affects the peripheral nervous system. Severe motor deficit (SMD), respiratory impairment, cranial nerve involvement and autonomic dysfunction are associated with a poor prognosis. Objective: To investigate the association between the clinical-epidemiological characteristics and the discharge results among Peruvian patients with GBS. Methods: We carried out a retrospective observational study on patients with GBS who survived until discharge. We used the Brighton Collaboration’s criteria and considered Hughes Severity Scale (HSS) scores greater than two to be SMD. We defined the discharge results as an improvement if the HSS score decreased by at least one point from admission to hospital discharge and defined hospital stay as prolonged if > 14 days. Results: We analyzed 92 patients, among whom 70.7% were male. Quadriparesis (81.1%) and hyporeflexia (86.8%) were the most characteristic manifestations. We observed that more than half of the cases were in summer and winter. Gastrointestinal infections were associated with a higher proportion of prolonged stays. The proportion of improvement was lower among patients who had an SMD at hospital admission. We confirmed these results through fitting in multivariate models. Conclusions: The prolonged stay was related to previous gastrointestinal infection, while a less improvement in SMD individuals at admission. Prospective multicenter surveillance systems are needed for monitoring GBS cases in low-income settings like Peru.

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Section: Discussionsupporting

confidence: 90%

Clinical-epidemiological characteristics associated with discharge outcomes and seasonality among surviving patients with Guillain-Barré syndrome in a national third-level hospital, Lima, Peru

Velásquez-Rimachi

López-Saavedra

Rodriguez-López

et al. 2021

Arq. Neuro-Psiquiatr.

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“…The most common form in nerve conduction studies was AIDP, consistent with the literature (58% to 66.7%) 25 , 27 , 28 , 35 , 36 . The AMAN and AMSAN rates were 17% and 15%, respectively, consistent with a study in Chile that reported 26.7% axonal forms 27 .…”

Section: Discussionsupporting

confidence: 88%

“…Forty-nine percent of cases in the outcome evaluation had a degree of disability of 0 or 1, similar to the results of Thai and Canadian studies 28 , 35 . The last evaluations were performed via videoconference in some cases because of the COVID-19 pandemic.…”

Section: Discussionsupporting

confidence: 81%

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Frequency of exposure to arboviruses and characterization of Guillain Barré syndrome in a clinical cohort of patients treated at a tertiary referral center in Brasília, Federal District

Matos

Borges

Palmeira

et al. 2022

Rev. Soc. Bras. Med. Trop.

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Background: Guillian Barré syndrome (GBS) is an acute autoimmune polyradiculoneuropathy often associated with previous exposure to infectious agents. Methods: A clinical cohort of 41 patients with GBS admitted to the Base Hospital Institute of the Federal District between May 2017 and April 2019 was followed up for 1 year. Serological tests for arbovirus detection and amplification of nucleic acids using polymerase chain reaction for zika virus (ZIKV), dengue virus (DENV), and chikungunya virus (CHIKV) were performed. Results: The cohort consisted of 61% men with a median age of 40 years, and 83% had GBS-triggering events. A total of 54% had Grade 4 disability, 17% had Grade 3, 12% had Grade 2, 10% had Grade 5, and 7% had Grade 1. The classic form occurred in 83% of patients. Nerve conduction evaluations revealed acute demyelinating inflammatory polyneuropathy (51%), acute motor axonal neuropathy (17%), acute sensory-motor neuropathy (15%), and indeterminate forms (17%). Four patients were seropositive for DENV. There was no laboratory detection of ZIKV or CHIKV infection. Ninety percent of patients received human immunoglobulin. Intensive care unit admission occurred in 17.1% of the patients, and mechanical ventilation was used in 14.6%. One patient died of Bickerstaff’s encephalitis. Most patients showed an improvement in disability at 10 weeks of follow-up. Conclusions: GBS in the Federal District showed a variable clinical spectrum, and it was possible to detect recent exposure to DENV.

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“…In fact, there are many good population‐based studies available about disability 44 , 45 , 46 , 47 , 48 , 49 and quality of life 16 , 21 , 50 , 51 , 52 , 53 after GBS. The number of patients with poor functional outcomes differs between the studies 29 , 54 , 55 , 56 , 57 depending on the time interval after GBS, the definition of impaired function, symptoms analyzed, ICU treatment and necessity of mechanical ventilation, the studied population, and regional differences 44 as well.…”

Section: Discussionmentioning

confidence: 99%

Patients' attitude towards vaccination after Guillain Barré syndrome

Holtz

Grimm²,

Axer

2021

Health Science Reports

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Background and Aims Guillain Barré syndrome (GBS) could be triggered by an infectious disease but by vaccination as well. Thus, suffering GBS may influence patients' attitudes towards vaccination. Methods An anonymous questionnaire consisting of the Overall Neuropathy Limitations Score (ONLS), the short form‐36 health survey (SF‐36), and questions addressing patients' attitude towards vaccination was sent to members of a German GBS support group and to patients with GBS diagnosis who were treated at Jena University Hospital. Results Ninety‐seven questionnaires clearly stated GBS as a diagnosis and were included in the analysis. Although 19.6% of the GBS patients reported having no disability in the long‐time follow‐up, a considerable number of patients still had persistent neurological symptoms; 74.2% of the GBS patients reported being able to walk at least 10 m independently. However, 5.2% were restricted to wheelchair. The patients reached lower scores in all domains of quality of life compared to German controls. Moreover, patients showed a more critical attitude towards vaccination compared to a German representative survey. Fewer patients (58.8%) received a vaccination after suffering from GBS than before (77.3%). Every tenth patient believed that vaccination was the trigger for the GBS. 32% of the patients did not receive a vaccination in the last 5 years mainly because of the fear of adverse effects (32%) or disadvise of the general practitioners (25.8%). Discussion Although the risk of relapse following immunization may be rather low, uncertainties and fears still impair the counseling of these patients by their medical practitioner.

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Three-Year Follow-Up Study in Patients with Guillain-Barré Syndrome

Abstract: Un an et trois ans après l'apparition des premiers symptômes du SGB, un nombre important de patients donnaient à voir des séquelles neurologiques, ce qui incluait une forme ou une autre d'incapacité fonctionnelle, des symptômes sensoriels, des douleurs et un état de fatigue.

Cited by 11 publications

References 37 publications

Clinical-epidemiological characteristics associated with discharge outcomes and seasonality among surviving patients with Guillain-Barré syndrome in a national third-level hospital, Lima, Peru

Clinical-epidemiological characteristics associated with discharge outcomes and seasonality among surviving patients with Guillain-Barré syndrome in a national third-level hospital, Lima, Peru

Frequency of exposure to arboviruses and characterization of Guillain Barré syndrome in a clinical cohort of patients treated at a tertiary referral center in Brasília, Federal District

Patients' attitude towards vaccination after Guillain Barré syndrome

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