Three-year outcomes of dietary fatty acid modification and house dust mite reduction in the Childhood Asthma Prevention Study

Peat, Jennifer K.; Mihrshahi, Seema; Kemp, Andrew; Marks, Guy B.; Tovey, Euan R.; Webb, Karen; Mellis, Craig; Leeder, Stephen

doi:10.1016/j.jaci.2004.06.057

Cited by 187 publications

(144 citation statements)

References 30 publications

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“…Of these studies, four trials (eight reports) compared omega 3 marine fatty acid supplements with placebo (6,17,(26)(27)(28)(29)(30)(31). These four trials enrolled 679 participants.…”

Section: Resultsmentioning

confidence: 99%

Omega 3 and 6 oils for primary prevention of allergic disease: systematic review and meta‐analysis

Anandan

Nurmatov

Sheikh

2009

Allergy

123

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Background: There is conflicting evidence on the use of omega 3 and omega 6 supplementation for the prevention of allergic diseases. We conducted a systematic review evaluating the effectiveness of omega 3 and 6 oils for the primary prevention of sensitization and development of allergic disorders.Methods: We searched The Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE, LILACS, PsycInfo, AMED, ISI Web of Science and Google Scholar for double‐blind randomized controlled trials. Two authors independently assessed articles for inclusion. Meta‐analyses were undertaken using fixed effects modelling, or random effects modelling in the event of detecting significant heterogeneity.Results: Of the 3129 articles identified, 10 reports (representing six unique studies) satisfied the inclusion criteria. Four studies compared omega 3 supplements with placebo and two studies compared omega 6 supplements with placebo. There was no clear evidence of benefit in relation to reduced risk of allergic sensitization or a favourable immunological profile. Meta‐analyses failed to identify any consistent or clear benefits associated with use of omega 3 [atopic eczema: RR = 1.10 (95% CI 0.78–1.54); asthma: RR = 0.81 (95% CI 0.53–1.25); allergic rhinitis: RR = 0.80 (95% CI 0.34–1.89) or food allergy RR = 0.51 (95% CI 0.10–2.55)] or omega 6 oils [atopic eczema: RR = 0.80 (95% CI 0.56–1.16)] for the prevention of clinical disease.Conclusions: Contrary to the evidence from basic science and epidemiological studies, our systematic review and meta‐analysis suggests that supplementation with omega 3 and omega 6 oils is probably unlikely to play an important role as a strategy for the primary prevention of sensitization or allergic disease.

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“…Of these studies, four trials (eight reports) compared omega 3 marine fatty acid supplements with placebo (6,17,(26)(27)(28)(29)(30)(31). These four trials enrolled 679 participants.…”

Section: Resultsmentioning

confidence: 99%

Omega 3 and 6 oils for primary prevention of allergic disease: systematic review and meta‐analysis

Anandan

Nurmatov

Sheikh

2009

Allergy

123

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“…The Australian study was not able to show any differences at age 5 years and only a slight reduction in sensitization rates (7.2% vs. 10%) in the active group at age 3 years [66].…”

Section: Implications For Intervention Studiesmentioning

confidence: 68%

Primary prevention of allergy: avoiding risk or providing protection?

Hamelmann

Beyer

Grüber

et al. 2007

Clin Experimental Allergy

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SummaryPrimary prevention strategies of allergy so far have been aimed to fight allergy causes, by avoiding risk factors and inhibiting their mechanisms of action. The results of trials testing food or airborne allergen avoidance as a prevention strategy were, however, rather disappointing. A reverse approach for primary prevention of allergies aims to facilitate exposure to protecting factors which promote the induction of immunologic tolerance against innocuous antigens. These factors are associated with farming environment and a 'traditional lifestyle', but identification of these factors is quite difficult. Major candidates include foodborne microbes, helminths or their components, which are able to stimulate mucosal immunity, particularly in the gut. Similarly, new preventive and therapeutic strategies are being tested to induce specific food-allergen oral tolerance through the ingestion of progressively increasing doses of the offending food. This shifting of allergy prevention research from avoidance to tolerance induction will hopefully allow us to reverse the epidemic trend of allergy diseases.

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“…37 Balık yağları yüksek oranda n-3 yağ asidi içer-mektedir ve n-3 yağ asitlerinin solunum yolu inflamasyonunu azaltabilen bir antiinflamatuar olduğu ifade edilmektedir. 38 Almqvist ve ark.nın çalışmasında, diyetle n-3 ve n-6 alımının hırıltılı solunum ile ilişkisinin olmadığı gösterilmiştir. 39 Ço-cuklar üzerinde yapılan bir başka çalışmada, birinci gruptaki çocuklara yüksek n-3 yağ asidi, düşük n-6 yağ asidi içeren diyet verilir iken; ikinci gruba düşük n-3 yağ asidi ve yüksek n-6 yağ asidi içeren diyet verilmiştir.…”

Section: Di̇yeti̇n Yağ İçeri̇ği̇unclassified

Interaction of Asthma and Nutrition: Review

Elibol¹,

Şanlıer²

2017

Turkiye Klinikleri Arch Lung

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Three-year outcomes of dietary fatty acid modification and house dust mite reduction in the Childhood Asthma Prevention Study

Cited by 187 publications

References 30 publications

Omega 3 and 6 oils for primary prevention of allergic disease: systematic review and meta‐analysis

Omega 3 and 6 oils for primary prevention of allergic disease: systematic review and meta‐analysis

Primary prevention of allergy: avoiding risk or providing protection?

Interaction of Asthma and Nutrition: Review

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