Three-year results from a preclinical implantation study of a long-term resorbable surgical mesh with time-dependent mechanical characteristics

Hjort, H; Mathisen, Torbjörn; Alves, Antoine; Clermont, Gaëlle; Boutrand, Jean-Pierre

doi:10.1007/s10029-011-0885-y

Cited by 92 publications

(93 citation statements)

References 22 publications

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“…The knitted structure of TIGR ® Matrix allows for easy handling and fixation while being strong and flexible. As shown in preclinical trials, it is rapidly vascularized, has a transient inflammatory response, and, over time, is replaced by well-organized connective tissue [18]. This was also our observation during this study.…”

Section: Discussionsupporting

confidence: 85%

“…About 2 weeks after implantation TIGR ® Matrix will gradually become softer and more flexible due to the ongoing degradation in the fast-degrading fiber, unlocking the knitting pattern of the slow-degrading fiber. The slow-degrading fibers keep their mechanics up to 6–9 months and are completely resorbed after ~3 years due to degradation by hydrolysis [18]. …”

Section: Methodsmentioning

confidence: 99%

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The Use of Synthetic Mesh in Reconstructive, Revision, and Cosmetic Breast Surgery

Becker

Lind

2013

Aesth Plast Surg

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BackgroundRecent evidence suggests that the use of acellular dermal matrices in prosthetic breast reconstruction, revision, or augmentation may be associated with an increased risk of complications. In this article we report our results of a potential alternative, using a new long-term resorbable synthetic matrix in these cases.MethodsA retrospective study was performed evaluating 11 primary breast reconstructions (19 breasts), 43 secondary reconstructions (77 breasts), 3 augmentation/augmentation mastopexys (6 breasts), and 5 mastopexys (10 breasts) in 62 patients using TIGR® Matrix Surgical Mesh.ResultsFollow-up ranged from 9.4 to 26.1 months with an average follow-up of 16.5 months. Average age was 54 years. The number of patients who had prior radiation was 9 (14.5 %). Four patients (6.5 %) were smokers. Postoperative breast complications included necrosis of two flaps (1.8 %), two seromas requiring drainage (1.8 %), four infection/extrusions (3.6 %), two relapses of inframammary fold/malposition (1.8 %), and two with rippling (1.8 %). Other complications included six cases of asymmetry that required a corrective procedure. In a variety of breast surgery cases very good aesthetic results were achieved.ConclusionThe long-term absorbable synthetic matrix, TIGR® Matrix Surgical Mesh, shows potential when used as temporary reinforcement in patients undergoing breast reconstruction or breast surgery revisions and in primary aesthetic procedures, and it appears to be a viable alternative to the use of acellular dermal matrices.Level of Evidence IVThis journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors http://www.springer.com/00266.

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Section: Discussionsupporting

confidence: 85%

Section: Methodsmentioning

confidence: 99%

The Use of Synthetic Mesh in Reconstructive, Revision, and Cosmetic Breast Surgery

Becker

Lind

2013

Aesth Plast Surg

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“…The initial burst strength of the mesh implant as measured according to American Society for Testing and Materials D3787 is above 300 N. This strength is comparable to existing commercially available products that range between 170 and 750 N. More than 50 % of the initial mechanical strength of the mesh, above theoretical and measured values of the highest forces acting on the abdominal wall [8, 9], is maintained during the first 26 weeks, after that the mechanical strength of the mesh is gradually lost [7]. …”

Section: Methodsmentioning

confidence: 82%

Inguinal hernia repair using a synthetic long-term resorbable mesh: results from a 3-year prospective safety and performance study

Ruiz-Jasbon

Norrby

Ivarsson

et al. 2014

Hernia

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PurposeConventional meshes for hernia repair and abdominal wall reinforcement are usually made from polypropylene, polyester or other synthetic plastic materials known to promote foreign body reactions and a state of chronic inflammation that may lead to long-term complications. A novel approach is to use long-term resorbable implants like TIGR® Matrix Surgical Mesh. Preclinical studies have shown that this mesh maintains mechanical integrity beyond the point in time where newly formed tissue is capable of carrying the abdominal loads.MethodsThis was a first-in-man, prospective, pilot study performed during 2009, at two sites in Sweden. Forty patients with primary inguinal hernias were enrolled for Lichtenstein repair using TIGR® Matrix Surgical Mesh. The primary endpoint was safety as assessed by monitoring the incidence of adverse events and serious adverse events (SAEs) both related and unrelated to the mesh. The secondary endpoint was pain or discomfort. Visual Analogue Scale (VAS) 0–10 and Inguinal Pain Questionnaire were used for scoring pain and discomfort. Included patients have been followed for 36 months using ultrasound in combination with clinical examination.ResultsAll patients followed a normal early postoperative course. After 12 months no SAEs were reported. None of the patients with an isolated lateral inguinal hernia (LIH) had developed a recurrence but 4 (44 %) with medial and 4 (33 %) with combined hernias had recurred at 36-month follow-up. After 3-year follow-up none of the patients with LIH reported pain in the VAS-form and none of those patients could feel the sensation of a mesh in their groin. In the total study population 5 (16 %) patients experienced chronic pain in the form of mild sporadic pain and 3 (9.7 %) patients could feel the sensation of a mesh in their groin.ConclusionThe use of a synthetic long-term resorbable mesh (TIGR® Matrix Surgical Mesh) in Lichtenstein repair was found to be safe, without recurrences, and promising regarding pain/discomfort at 3-year follow-up in patients with LIH. However, patients with medial and combined inguinal hernias had high recurrence rates.

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“…Following implantation in the abdomen of a sheep model, strong connective tissue was observed after 36 months, with none of the animals showing recurrence at the end of the study. The authors stated that this is the world’s first long-term resorbable mesh and takes a minimum of 6 months to degrade, thereby allowing sufficient time for a collagen matrix to form [67]. Similarly, de Tayrac et al demonstrated that the use of polylactic acid (PLA) could be a promising alternative material for long-lasting pelvic floor repair because of its slower degradation rate, which is attributed to the small fibres.…”

Section: Materials Discussionmentioning

confidence: 99%

In vivo response to polypropylene following implantation in animal models: a review of biocompatibility

Kelly¹,

Macdougall²,

Olabisi³

et al. 2016

Int Urogynecol J

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Introduction and hypothesisPolypropylene is a material that is commonly used to treat pelvic floor conditions such as pelvic organ prolapse (POP) and stress urinary incontinence (SUI). Owing to the nature of complications experienced by some patients implanted with either incontinence or prolapse meshes, the biocompatibility of polypropylene has recently been questioned. This literature review considers the in vivo response to polypropylene following implantation in animal models. The specific areas explored in this review are material selection, impact of anatomical location, and the structure, weight and size of polypropylene mesh types.MethodsAll relevant abstracts from original articles investigating the host response of mesh in vivo were reviewed. Papers were obtained and categorised into various mesh material types: polypropylene, polypropylene composites, and other synthetic and biologically derived mesh.ResultsPolypropylene mesh fared well in comparison with other material types in terms of host response. It was found that a lightweight, large-pore mesh is the most appropriate structure.ConclusionThe evidence reviewed shows that polypropylene evokes a less inflammatory or similar host response when compared with other materials used in mesh devices.Electronic supplementary materialThe online version of this article (doi:10.1007/s00192-016-3029-1) contains supplementary material, which is available to authorized users

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Three-year results from a preclinical implantation study of a long-term resorbable surgical mesh with time-dependent mechanical characteristics

Cited by 92 publications

References 22 publications

The Use of Synthetic Mesh in Reconstructive, Revision, and Cosmetic Breast Surgery

The Use of Synthetic Mesh in Reconstructive, Revision, and Cosmetic Breast Surgery

Inguinal hernia repair using a synthetic long-term resorbable mesh: results from a 3-year prospective safety and performance study

In vivo response to polypropylene following implantation in animal models: a review of biocompatibility

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