Three-year survival after four major post–cardiac operative complications*

Hein, Ortrud Vargas; Birnbaum, Jürgen; Wernecke, Klaus D.; Konertz, Wolfgang; Jain, Uday; Spies, Claudia

doi:10.1097/01.ccm.0000242519.71319.ad

Cited by 70 publications

(51 citation statements)

References 52 publications

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“…In patients whose ICU stay was > 14 days, the stay was shorter in the patients with a VAD (median [25% quartile, 75% quartile], 23 [19,37]) days) than in those without (28 [21,40] …”

Section: Univariate and Multivariate Analysesmentioning

confidence: 99%

Intensive Care Unit Stay of More than 14 Days after Cardiac Surgery is Associated with Non-cardiac Organ Failure

et al. 2006

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Some studies have shown an association between a prolonged intensive care unit (ICU) stay and risk factors such as mediastinal re-exploration, advanced age, low ejection fraction, lung disease and organ failure. The aim of this retrospective study was first to evaluate peri-operative risk factors (n = 2683) and secondly to evaluate long-term survival (n = 2563) in cardiac surgery patients with an ICU stay > 14 days. Long-term survival was assessed in an observational 3-year follow-up study. An ICU stay of > 14 days was associated independently with respiratory failure and dialysis-dependent acute renal failure, and with a significantly lower survival rate. Since an ICU stay is associated with a higher hospital and long-term mortality, measures should be taken throughout the entire hospital stay to identify and reduce the risk of organ failure.

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“…In patients whose ICU stay was > 14 days, the stay was shorter in the patients with a VAD (median [25% quartile, 75% quartile], 23 [19,37]) days) than in those without (28 [21,40] …”

Section: Univariate and Multivariate Analysesmentioning

confidence: 99%

Intensive Care Unit Stay of More than 14 Days after Cardiac Surgery is Associated with Non-cardiac Organ Failure

et al. 2006

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“…65 Both surgical re-exploration and red blood cell transfusion are associated in a dose-dependent and often durable manner with prolonged intensive care and hospital stays and reduced survival rates. 66,67 There are international differences in the threshold for transfusions and probably also for rates of reoperation for bleeding associated with the use of scorecards. 68 In a pooled analysis of the ACUITY and HORIZONS-AMI trials, CABG-related major ACUITY-graded bleeding in a time-adjusted baseline covariate-adjusted Cox model of 1600 patients did not independently predict subsequent 12-month mortality (hazard ratio, 1.21; 95% confidence interval, 0.81 to 1.80; Pϭ0.34).…”

Section: Special Considerations For Coronary Artery Bypass Graft-relamentioning

confidence: 99%

Standardized Bleeding Definitions for Cardiovascular Clinical Trials

et al. 2011

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A dvances in antithrombotic therapy, along with an early invasive strategy, have reduced the incidence of recurrent ischemic events and death in patients with acute coronary syndromes (ACS; unstable angina, non-ST-segment-elevation myocardial infarction [MI], and ST-segment-elevation MI). [1][2][3][4] However, the combination of multiple pharmacotherapies, including aspirin, platelet P2Y 12 inhibitors, heparin plus glycoprotein IIb/IIIa inhibitors, direct thrombin inhibitors, and the increasing use of invasive procedures, has also been associated with an increased risk of bleeding.

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“…2 test, unpaired t test, or Fisher exact test was used as appropriate. Second, additive scores from both models were calculated for every patient by adding points for each risk variable present as in the original studies.…”

Section: Statistical Analysesmentioning

confidence: 99%

“…The incidence of acute kidney injury (AKI) in this setting varies depending on the definition used and the specific population studied. Even considering only its most severe form, defined by the need for renal replacement therapy (RRT), AKI rates after cardiac surgery range between 0.33% (1) and 9.5% (2). Besides patient-and procedurerelated factors, local practice patterns may partially explain this nearly 30-fold difference (3).…”

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confidence: 99%

Predicting Acute Renal Failure after Cardiac Surgery

Candela-Toha

Elías-Martín

Abraira

et al. 2008

Clinical Journal of the American Society of Nephrology

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Results: Frequency of acute kidney injury after cardiac surgery was 3.7% in the cohort used to validate the Cleveland score and 3.8% in the cohort used to validate the Toronto score. Discrimination of both models was excellent, with values for the areas under the receiving operator characteristics curves of 0.86 (95% confidence interval 0.81 to 0.9) and 0.82 (95% confidence interval 0.76 to 0.87), respectively. Calibration was poor, with underestimation of the risk for acute kidney injury except for patients within the very-low-risk category. The performance of both models clearly improved after recalibration.Conclusions: Both models were found to be very useful to discriminate between patients who will and will not develop acute kidney injury after cardiac surgery; however, before using the scores to estimate risk probabilities at a specific center, recalibration may be needed.

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Three-year survival after four major post–cardiac operative complications*

Abstract: Successful acute treatment and measures to identify and reduce the risk of major morbidities are necessary to improve outcome. In addition, long-term follow-up and management of morbidities are necessary to possibly improve long-term survival.

Cited by 70 publications

References 52 publications

Intensive Care Unit Stay of More than 14 Days after Cardiac Surgery is Associated with Non-cardiac Organ Failure

Intensive Care Unit Stay of More than 14 Days after Cardiac Surgery is Associated with Non-cardiac Organ Failure

Standardized Bleeding Definitions for Cardiovascular Clinical Trials

Predicting Acute Renal Failure after Cardiac Surgery

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