Threonine 48 in the BIR domain of survivin is critical to its mitotic and anti-apoptotic activities and can be phosphorylated by CK2 in vitro

Clinical aspects for survivin: a crucial molecule for targeting drug-resistant cancers

“…Uncited references Q12 [2,3,7,9,[11][12][13][14][16][17][18][19][20][21][22][24][25][26]50,59,65,66,70,91,92,97,[111][112][113].…”

FOXM1 is a critical driver of lung fibroblast activation and fibrogenesis

“…FOXM1 regulates its own transcription as well as that of a number of cell cycle genes, including CCND1, involved in G 1 /S progression, and CCNB1 and PLK1, both of which are critical for G 2 /M transition. FOXM1 also upregulates BIRC5 (also known as survivin), a gene critical for mitotic spindle checkpoint integrity and for antiapoptotic activity (8)(9)(10).…”

Identification of a novel function of the clathrin-coated structure at the plasma membrane in facilitating GM-CSF receptor-mediated activation of JAK2

“…25 On the other hand, caseine kinase (CK2) is a highly conserved serine/threonine kinase with a broad subcellular localization. 26,27 CK2 is also enriched in clathrin-coated vesicles (CCV) and can phosphorylate many accessory proteins involved in clathrinmediated endocytosis (CME) pathway, including AP2, amphiphysin and clathrin light chain (CLC). 28 Recently, Zheng et al demonstrated that JAK2 activation by oncostatin M, IFNγ and growth hormone and auto-activation of JAK2V617F are both CK2-dependent.…”