Threshold and subthreshold bipolar disorders in the Sesto Fiorentino Study

Faravelli, Carlo; Rosi, S.; Scarpato, Maria Alessandra; Lampronti, L.; Amedei, S. Gorini; Rana, Nusrat

doi:10.1016/j.jad.2006.01.031

Cited by 28 publications

(17 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the cities, the age-related incidence of bipolar disorder varied between 1.7% and 6.2% [20]. Faravelli et al [16] found the prevalence of bipolar I and II disorder to be 0.5% and 0.4%, respectively.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

A systematic review of the evidence of the burden of bipolar disorder in Europe

Fajutrao

Locklear

Priaulx

et al. 2009

Clin Pract Epidemiol Ment Health

131

View full text Add to dashboard Cite

BackgroundBipolar disorder is recognized as a major mental health issue, and its economic impact has been examined in the United States. However, there exists a general scarcity of published studies and lack of standardized data on the burden of the illness across European countries. In this systematic literature review, we highlight the epidemiological, clinical, and economic outcomes of bipolar disorder in Europe.MethodsA systematic review of publications from the last 10 years relating to the burden of bipolar disorder was conducted, including studies on epidemiology, patient-related issues, and costs.ResultsData from the UK, Germany, and Italy indicated a prevalence of bipolar disorder of ~1%, and a misdiagnosis rate of 70% from Spain. In one study, up to 75% of patients had at least one DSM-IV comorbidity, commonly anxiety disorders and substance/alcohol abuse. Attempted suicide rates varied between 21%–54%. In the UK, the estimated rate of premature mortality of patients with bipolar I disorder was 18%. The chronicity of bipolar disorder exerted a profound and debilitating effect on the patient. In Germany, 70% of patients were underemployed, and 72% received disability payments. In Italy, 63%–67% of patients were unemployed. In the UK, the annual costs of unemployment and suicide were £1510 million and £179 million, respectively, at 1999/2000 prices. The estimated UK national cost of bipolar disorder was £4.59 billion, with hospitalization during acute episodes representing the largest component.ConclusionBipolar disorder is a major and underestimated health problem in Europe. A number of issues impact on the economic burden of the disease, such as comorbidities, suicide, early death, unemployment or underemployment. Direct costs of bipolar disorder are mainly associated with hospitalization during acute episodes. Indirect costs are a major contributor to the overall economic burden but are not always recognized in research studies.

show abstract

Section: Resultsmentioning

confidence: 99%

“…Fourteen studies showed evidence that patients with bipolar disorder suffer from comorbidities (Table 2) [15,16,22,24-34]. In particular, the evidence for concurrent mental disorders is strong compared with other conditions.…”

Section: Resultsmentioning

confidence: 99%

A systematic review of the evidence of the burden of bipolar disorder in Europe

Fajutrao

Locklear

Priaulx

et al. 2009

Clin Pract Epidemiol Ment Health

131

View full text Add to dashboard Cite

show abstract

“…Reported rates of anxiety syndromes have been higher among women than men diagnosed with BD in several [42,59,66] but not all studies. 43 14.0 12.6 ----Goodwin and Hoven [39] 35.0 --------Simon et al [48] 17.5 30.3 18.3 17.1 9.89 Baldassano et al [59] 0.83 20.3 --15.4 9.54 Grant et al [60] 19.0 21.8 21.8 ----Faravelli et al [61] 16.0 --24.0 ----Mantere et al [62] 24.1 27.8 15.2 10.5 2.09 Benedetti et al [63] 40.0 ------48.0 Merikangas et al [ 4] 28.0 36.5 37.8 32.8 22.8 Albert et al [65] 10.5 6.67 16.2 --13.3 Altshuler et al [66] 18.8 19.7 --8.02 8.30 Das [68] 15.5 28.6 21.4 --7.10 Saunders et al [67] 25.1 15.4 ------Baldessarini et al [69] 33 Kessler et al [38] 27/29 [92.9] ----Angst [36] --34/59 [57.6] --McElroy et al [44] 100/239 [41.8] 22/49 [44.9] 0.93 Doughty et al [61] 28/100 [28.0] 25/65 [38.5] 0.73 Simon et al [48] 190 We identified 12 reports on rates of anxiety disorders in patients diagnosed with BD subtypes ( Table 3). 43 14.0 12.6 ----Goodwin and Hoven [39] 35.0 --------Simon et al [48] 17.5 30.3 18.3 17.1 9.89 Baldassano et al [59] 0.83 20.3 --15.4 9.54 Grant et al [60] 19.0 21.8 21.8 ----Faravelli et al [61] 16.0 --24.0 ----Mantere et al [62] 24.1 27.8 15.2 10.5 2.09 Benedetti et al [63] 40.0 ------48.0 Merikangas et al [ 4] 28.0 36.5 37.8 32.8 22.8 Albert et al [65] 10.5 6.67 16.2 --13.3 Altshuler et al [66] 18.8 19.7 --8.02 8.30 Das …”

Section: Prevalence Of Anxiety Syndromes In Bd Patientsmentioning

confidence: 99%

“…Doughty et al[61] is for recurrent panic only. Random effects meta-analysis also indicated no significant difference by diagnostic subtype (RR = 1.00; 95% CI: 0 88.…”

mentioning

confidence: 99%

Co-Occurrence of Anxiety and Bipolar Disorders: Clinical and Therapeutic Overview

2014

View full text Add to dashboard Cite

show abstract

“…A more recent cross-sectional, face-to-face, household survey in 11 countries in the Americas, Europe, and Asia reported that the lifetime prevalence was 0.6% for BD-I and 0.4% for BD-II, while the year prevalence was 0.4% and 0.3%, respectively (Merikangas et al, 2011). A few studies report on the epidemiology of bipolar spectrum and suggest that in the adult population the lifetime prevalence of the bipolar spectrum is between 3 and 8.3% (Weissman and Myers, 1978; Angst et al, 1984, 2005b; Oliver and Simmons, 1985; Wicki and Angst, 1991; Heun and Maier, 1993; Angst, 1998; Szadoczky et al, 1998; Hirschfeld et al, 2003a, 2003b; Judd and Akiskal, 2003; Moreno and Andrade, 2005; Faravelli et al, 2006; Kessler et al, 2006). …”

Section: Introductionmentioning

confidence: 99%

The International College of Neuropsychopharmacology (CINP) Treatment Guidelines for Bipolar Disorder in Adults (CINP-BD-2017), Part 1: Background and Methods of the Development of Guidelines

Fountoulakis

Young

Yatham

et al. 2016

IJNPPY

View full text Add to dashboard Cite

Background:This paper includes a short description of the important clinical aspects of Bipolar Disorder with emphasis on issues that are important for the therapeutic considerations, including mixed and psychotic features, predominant polarity, and rapid cycling as well as comorbidity.Methods:The workgroup performed a review and critical analysis of the literature concerning grading methods and methods for the development of guidelines.Results:The workgroup arrived at a consensus to base the development of the guideline on randomized controlled trials and related meta-analyses alone in order to follow a strict evidence-based approach. A critical analysis of the existing methods for the grading of treatment options was followed by the development of a new grading method to arrive at efficacy and recommendation levels after the analysis of 32 distinct scenarios of available data for a given treatment option.Conclusion:The current paper reports details on the design, method, and process for the development of CINP guidelines for the treatment of Bipolar Disorder. The rationale and the method with which all data and opinions are combined in order to produce an evidence-based operationalized but also user-friendly guideline and a specific algorithm are described in detail in this paper.

show abstract

Threshold and subthreshold bipolar disorders in the Sesto Fiorentino Study

Cited by 28 publications

References 43 publications

A systematic review of the evidence of the burden of bipolar disorder in Europe

A systematic review of the evidence of the burden of bipolar disorder in Europe

Co-Occurrence of Anxiety and Bipolar Disorders: Clinical and Therapeutic Overview

The International College of Neuropsychopharmacology (CINP) Treatment Guidelines for Bipolar Disorder in Adults (CINP-BD-2017), Part 1: Background and Methods of the Development of Guidelines

Contact Info

Product

Resources

About