Threshold effect of systemic immune inflammatory index on hypertension in American adults (NHANES 2017–2020)

Abstract

Background and aims: Research reports on the relationship between systemic immune-inflammation index (SII) and hypertension are limited. We aim to evaluate the possible relationship between SII and hypertension. Methods and results: We conducted a cross-sectional analysis of adults from the National Nutrition and Health Database from 2017 to 2020. In this study, 13 742 participants were included. The exposure variable in this study was the systemic inflammatory state as defined by SII and an outcome was hypertension. There is a nonlinear association between SII and hypertension. Two piecewise logistic regression models were used to analyze the relationship between them and calculated the cut-off point of SII to be 501.2. We found that SII on the left side of the cut-off point has nothing to do with the prevalence of hypertension. However, in patients with SII at least 501.2, the prevalence of hypertension increased with the increase of SII (odds ratio, 3.13; 95% confidence interval, 2.04–4.81). The nonlinear association between LgSII and hypertension still existed stably in the subgroups of sex, age, BMI, diabetes, and cardiovascular disease (P for interaction > 0.05). Conclusion: A cross-sectional analysis reported the threshold effect of SII on and hypertension and calculated the turning point of SII to be 501.2. Graphical Abstract, http://links.lww.com/HJH/C283

The association between systemic immune-inflammation index and cardiotoxicity related to 5-Fluorouracil in colorectal cancer

“…Furthermore, in the clinical practice of using 5-FU, it is necessary to closely monitor the inflammatory status of patients in order to enable early prevention, monitoring, and management of cardiotoxicity related to 5-FU, especially when monocyte levels are low (T1:M ≤ 0.38 × 10 9 /L). A recent study has confirmed the close association between SII levels and the development of cardiovascular diseases, including hypertension, heart failure, and acute myocardial infarction [ 33 – 35 ]. In a meta-analysis conducted by Ye et al in 2022, which encompassed 152,996 patients across 13 studies, it was observed that elevated SII levels were linked to an increased risk of cardiovascular diseases such as ischemic stroke, hemorrhagic stroke, and myocardial infarction [ 36 ].…”

Systemic immune-inflammation index and its relation to blood pressure and dyslipidemia in adults: A retrospective study

“…The present study found a relationship between SII and hypertension aligning with prior research. [28–30] Three NHANES studies confirmed a positive relationship between SII and blood pressure. [28–30] In an NHANES examination of metabolic syndrome and SII, elevated blood pressure was significantly and positively linked with SII.…”

“…SII has been examined for its association with hypertension or blood pressure in several cross-sectional studies using data from the United States National Health and Nutrition Examination Survey (NHANES). [28–30] Each study found a positive, but not necessarily linear, relationship between the two. [28–30] Compared to other inflammatory markers (e.g., platelet-to-lymphocyte ratio, lymphocyte-to-monocyte ratio, and neutrophil-to-lymphocyte ratio), Xu et al [30] identify SII as a superior marker that could potentially be used as a warning for early identification of personal inflammatory response.…”

“…[28–30] Each study found a positive, but not necessarily linear, relationship between the two. [28–30] Compared to other inflammatory markers (e.g., platelet-to-lymphocyte ratio, lymphocyte-to-monocyte ratio, and neutrophil-to-lymphocyte ratio), Xu et al [30] identify SII as a superior marker that could potentially be used as a warning for early identification of personal inflammatory response. A retrospective study of 91 patients found SII was an independent predictor of nondipper hypertension.…”

Systemic inflammatory biomarkers are novel predictors of all-cause and cardiovascular mortality in individuals with osteoarthritis: a prospective cohort study using data from the NHANES

“…They were originally developed to predict survival and cancer recurrence [ 15 , 16 ]. Further studies indicated that elevated SII and SIRI values are prognostic indicators of poor clinical outcomes not only in cancers but also in numerous other diseases, including cardiovascular and cerebrovascular conditions [ 17 – 19 ]. Nonetheless, research into the associations of the SII and SIRI with mortality risk in OA patients is lacking.…”