2024
DOI: 10.3390/ijms25168774
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Threshold Interphase Delay for Bipolar Pulses to Prevent Cancellation Phenomenon during Electrochemotherapy

Veronika Malyško-Ptašinskė,
Aušra Nemeikaitė-Čėnienė,
Eivina Radzevičiūtė-Valčiukė
et al.

Abstract: Electroporation-based procedures employing nanosecond bipolar pulses are commonly linked to an undesirable phenomenon known as the cancelation effect. The cancellation effect arises when the second pulse partially or completely neutralizes the effects of the first pulse, simultaneously diminishing cells’ plasma membrane permeabilization and the overall efficiency of the procedure. Introducing a temporal gap between the positive and negative phases of the bipolar pulses during electroporation procedures may hel… Show more

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