Thresholded Area Over the Curve of Spectrometric Tissue Oxygen Saturation as an Indicator of Volume Resuscitability in Porcine Hemorrhagic Shock

Zenker, Sven; Polanco, Patricio M.; Kim, Hyung Kook; Torres, Andrés; Vodovotz, Yoram; Clermont, Gilles; Pinsky, Michael R.; Severyn, Donald A.; Puyana, Juan Carlos

doi:10.1097/ta.0b013e31812f6095

Cited by 7 publications

(2 citation statements)

References 15 publications

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“…It is for this reason that physiological parameters such as blood oxygenation and pH fail as early markers of blood loss. Significant delays in detection by vital organ tissue pO 2 measurements have been observed, 17 and while this approach has some promise it still has not achieved satisfactory levels of correlation with major organ failure and morbidity. 18 Because of the critical role that capillaries play in the first two stages of shock, in particular the early redistribution of flow away from peripheral tissue, we have chosen to measure cutaneous capillary blood flow as an early indicator of the onset of hemorrhagic shock.…”

Section: Working Principlementioning

confidence: 99%

Point-of-care optical tool to detect early stage of hemorrhage and shock

et al. 2014

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There is a critical unmet clinical need for a device that can monitor and predict the onset of shock: hemorrhagic shock or bleeding to death, septic shock or systemic infection, and cardiogenic shock or blood flow and tissue oxygenation impairment due to heart attack. Together these represent 141 M patients per year. We have developed a monitor for shock based on measuring blood flow in peripheral (skin) capillary beds using diffuse correlation spectroscopy, a form of dynamic light scattering, and have demonstrated proof-of-principle both in pigs and humans. Our results show that skin blood flow measurement, either alone or in conjunction with other hemodynamic properties such as heart rate variability, pulse pressure variability, and tissue oxygenation, can meet this unmet need in a small self-contained patch-like device in conjunction with a hand-held processing unit. In this paper we describe and discuss the experimental work and the multivariate statistical analysis performed to demonstrate proof-of-principle of the concept.

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Section: Working Principlementioning

confidence: 99%

Point-of-care optical tool to detect early stage of hemorrhage and shock

et al. 2014

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“…The porcine trauma/hemorrhagic shock model plays into the unique nature of each test animal by having the level of bleed defined by the subsequent MAP and not by the amount of blood shed. This allowing us to examine the specific compensating mechanisms, unique measures of decompensation and tissue viability and response to therapy [ 15 ]. High fidelity (256 Hz) hemodynamic waveform collection and low frequency endocrine, metabolic and immunologic parameters can also be recorded throughout the experiment.…”

Section: Introductionmentioning

confidence: 99%