2024
DOI: 10.1007/s00210-024-03436-6
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Thrombin receptor PAR4 cross-activates the tyrosine kinase c-met in atrial cardiomyocytes

Claudia Mittendorff,
Issam Abu-Taha,
Lena Kassler
et al.

Abstract: Thrombin supports coagulation-independent inflammation via protease-activated receptors (PAR). PAR4 is specifically increased in obese human atria, correlating with NLRP3 inflammasome activation. PAR4-mediated NLRP3 inflammasome activation in atrial cardiomyocytes is not known, nor have signaling partners been identified. Thrombin transactivates the hepatocyte growth factor receptor in some cancer cells, so we examined PAR4/c-met cross-talk in atrial cardiomyocytes and its possible significance in obesity. Car… Show more

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