Thrombo-inflammatory status and prognosis of acute type A aortic dissection

Significance of the thrombo-inflammatory status-based novel prognostic score as a useful predictor for in-hospital mortality of patients with type B acute aortic dissection

“…Thrombo-inflammatory status can reflect the nature and severity of cardiovascular disease, and could be associated with other pathophysiological processes [ 9 ]. However, neither inflammatory nor thrombotic markers alone, might be particularly predictive of AAD; thus, a multi-biomarker strategy that combines biomarkers across patho-biological axes of inflammation and thrombosis provides incremental prognostic information for prediction of AAD [ 8 , 10 , 36 ]. To verify the hypothesis, we combined WBC (an inflammatory biomarker) and MPV/PC ratio (a thrombotic biomarker) at admission, into a novel and simplified thrombo-inflammatory prognostic score, and found that this score was independently predictive of in-hospital complications and long-term mortality in patients with type A AAD with higher sensitivity and specificity compared to WBC or MPV/PC ratio alone [ 10 ].…”

“…However, it is challenging for physicians to identify high-risk patients with type B AAD in the early phase, especially in the emergency room. Inflammatory response and thrombosis play an important role in the progression of AAD; thrombo-inflammatory status is associated with the severity and type of AAD, and correlates with adverse outcomes [ 8 , 9 ]. Our previous study indicated that a novel prognostic score based on thrombo-inflammatory status (Simplified Thrombo-Inflammatory Prognostic Score, sTIPS) was a useful tool for stratifying high-risk patients with type A AAD, irrespective of surgical or medical treatment [ 10 ].…”

Letter by Du et al Regarding Article, “Neutrophil-to-Lymphocyte Ratio Predicts the Outcome of Acute Intracerebral Hemorrhage”

“…We found that combined information from multiple inflammatory and thrombotic biomarkers might be more informative. 3,4 To verify the hypothesis, we combined mean platelet volume to platelet count ratio (a thrombotic biomarker) and white blood cell count (an inflammatory biomarker) into a novel and simplified thromboinflammatory prognostic score and found that this score was independently predictive of in-hospital complications and long-term mortality in patients with type A acute aortic dissection with higher sensitivity and specificity compared with mean platelet volume/platelet count ratio or white blood cell count. 3 An NLR, an inflammatory biomarker, could occasionally predict the prognosis of patients with acute ICH with, a score combining both inflammatory and thrombotic biomarkers may be more practical for clinicians to identify high-risk patients, offering higher sensitivity and specificity.…”

Prognostic value of serum albumin for patients with acute aortic dissection

“…AAD is associated with an inflammatory reaction, thrombosis, and oxidative stress, evidenced by a significant elevation in inflammatory markers, such as C-reactive protein (CRP), D-dimer, platelets (PLT) count, mean PLT volume to count ratio, and matrix metalloproteinase 9. [9–14] However, a marker or a prognostic score that reflects multiple pathophysiological pathways may be superior to a single biomarker that reflects 1 pathophysiological pathway. [15] Serum albumin (SA), a stable protein in the human serum that is associated with systemic inflammation, thrombosis, and oxidative stress, is reported as a strong independent predictor of long-term mortality in cardiovascular disease.…”