Thromboangiitis obliterans and endothelial function

Azizi, Michel; Boutouyrie, Pierre; Bura-Rivière, A.; Peyrard, Séverine; Laurent, Stéphane; Fiessinger, Jean‐Noël

doi:10.1111/j.1365-2362.2010.02294.x

Cited by 22 publications

(15 citation statements)

References 34 publications

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“…A recent study comparing ten TAO patients in the acute phase and ten age-and sex-matched healthy subjects showed that TAO patients have a smaller brachial artery diameter with concentric and eutrophic remodelling and increased aortic stiffness. These differences are consistent with a diffuse and unopposed increase in vasomotor tone in the conduit arteries of the entire arterial system (Azizi et al 2010).…”

Section: Aetiologysupporting

confidence: 78%

Thromboangiitis Obliterans or Buerger's Disease

Bura

Asselineau

Rousseau

et al. 2011

Systemic Vasculitis

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Section: Aetiologysupporting

confidence: 78%

Thromboangiitis Obliterans or Buerger's Disease

Bura

Asselineau

Rousseau

et al. 2011

Systemic Vasculitis

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“…Importantly, the response of the brachial artery wall to nitroglycerine administration remained unchanged, suggesting that dilatation dysfunction results predominantly from endothelial injury. In contrast, Azizi et al [29] did not observe altered responsiveness of the brachial artery to ischemia, although they documented higher rigidity of the aorta in TAO patients.…”

Section: Injury To the Vascular Endothelium And Activation Of The Infmentioning

confidence: 82%

The Pathogenesis and Diagnosis of Thromboangiitis obliterans: Is It Still a Mystery?

Małecki¹,

Kluz²,

Przeździecka-Dołyk³

et al. 2015

Adv Clin Exp Med

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Thromboangiitis obliterans (TAO) is a rare disease of unknown etiology that results in the occlusion of limb arteries located distally to the elbow and knee. Despite the fact that more than one hundred years have passed since its first description, knowledge on the pathogenesis of TAO and precipitating factors is still limited. Due to a lack of decisive noninvasive diagnostic methods and geographical differences in the prevalence of this condition, data on TAO epidemiology also remains sparse. This review presents important evidence on the pathogenesis and the course of the condition, as well as diagnostic modalities, with a focus on differential diagnosis. Theories on the pathogenesis of TAO include the theory of an infectious disease, coagulation disorders and injury to vascular endothelium resulting in activation of the inflammatory response. Differential diagnosis should exclude thoracic outlet syndrome, blue toe syndrome, infectious endocarditis, popliteal entrapment syndrome, Takayasu disease, primary and secondary systemic vasculitis, antiphospholipid syndrome, infection with the anaerobic Clostridium sp. bacilli and some less common conditions.

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“…ICAM-1 is expressed on the vascular endothelium and binds to the ligand to promote the firm adhesion between monocytes and endothelial cells (16–18). Moreover, ICAM-1 is highly expressed in TAO, which is closely related to the TAO-induced increased expression of inflammatory factors, such as IL-1β, IL-6 and TNF-α.…”

Section: Discussionmentioning

confidence: 99%

Cilostazol on the expression of ICAM‑1, VCAM-1and inflammatory factors in plasma in patients with thromboangiitis obliterans

Song

Chen

2018

Exp Ther Med

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The effects of cilostazol on the expression of intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and inflammatory factors in plasma in patients with thromboangiitis obliterans (TAO) were studied. Plasma viscosity, fibrinogen, total cholesterol (TC) and triglyceride (TG) were detected for the healthy control, TAO and cilostazol groups, respectively. Results showed that compared with those in the control group, the plasma viscosity, fibrinogen, TC and TG levels in TAO group were significantly increased. By contrast, compared with those in TAO group, the plasma viscosity, fibrinogen, TC and TG levels in the cilostazol group were significantly decreased. ELISA results revealed that ICAM-1 and VCAM-1 expression levels in TAO group were obviously increased compared with those in control group. ICAM-1 and VCAM-1 expression levels in cilostazol group were obviously decreased compared with those in TAO group. According to RT-PCR, the mRNA expression levels of IL-1β, IL-6 and TNF-α in TAO group were significantly higher than those in control group, while the levels in cilostazol group were significantly decreased compared with those in TAO group. In addition, RT-PCR and western blotting proved that expression of both mRNA and protein of ICAM-1 and VCAM-1 in TAO group was significantly increased and obviously decreased after administration of cilostazol. The results of analysis of variance showed that the differences of ICAM-1 and VCAM-1 expression was statistically significant among the control, TAO and cilostazol groups (p<0.01). Cilostazol can significantly reduce the TAO-induced abnormal increase in ICAM-1, VCAM-1 and inflammatory factor expression in plasma in patients. It was proven that cilostazol has a good anti-TAO effect.

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Thromboangiitis obliterans and endothelial function

Abstract: Acute TAO is characterised by vasoconstriction and increased aortic stiffness in the absence of changes in flow-mediated dilation.

Cited by 22 publications

References 34 publications

Thromboangiitis Obliterans or Buerger's Disease

Thromboangiitis Obliterans or Buerger's Disease

The Pathogenesis and Diagnosis of Thromboangiitis obliterans: Is It Still a Mystery?

Cilostazol on the expression of ICAM‑1, VCAM-1and inflammatory factors in plasma in patients with thromboangiitis obliterans

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