Thrombocyte counts in mice after the administration of papaya leaf suspension

Sathasivam, Kathiresan V.; Ramanathan, Surash; Mansor, Sharif Mahsufi; Haris, Mas Rosemal M. H.; Wernsdorfer, Walther H.

doi:10.1007/s00508-009-1229-0

Cited by 43 publications

(27 citation statements)

References 12 publications

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“…A study in mice found an increase in thrombocyte counts in mice administered 15 mg of powdered papaya leaves/kg body weight between 1 and 12hrs following dosing [13]. Another study found that the C. papaya leaf aqueous extract at concentrations of 400 mg/kg and 800 mg/kg significantly increased the platelet counts in cyclophosphamide-induced thrombocytopenic rat model.…”

Section: Animal Studiesmentioning

confidence: 99%

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Carica Papaya; A Paired and Alternative Therapy of Dengue Fever

Nesar

Omer

Rizvi

et al. 2018

JBT

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The purpose f the study is to explore the prospective use of Carica papaya leaves extracts for Dengue fever that is a painful, debilitating mosquito-borne disease caused by dengue viruses. An estimated 390 million dengue infections occur worldwide each year, with about 96 million resulting in illness. It has been found at height in developing nations like India, Pakistan, Sri Lanka and Bangladesh. Mostly tropical areas have been reported infected. The disease is transmitted by an Aedes mosquito infected with a dengue virus; interestingly it is not transferred from person to person. Symptoms are mild to serious including hemorrhagic fever; a rare complication characterized by high fever, damage to lymph and blood vessels, bleeding from the nose and gums, enlargement of the liver, and failure of the circulatory system and it can cause the death. All the symptoms of disease are due to low platelets count that may become very low if not managed. Consequently, the research reveals that juice of the leaves of the Carica papaya plant from the family Caricaceae help to increase the platelet levels. The present review is done to enlighten the theory of the management of dengue through this alternative therapy that can be implement along with conventional treatment. The covered researches in present study would raise and support the possibility of being, the remedy and significant alternative in the prospect.

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Section: Animal Studiesmentioning

confidence: 99%

“…It also reduced the clotting time in the treated rats [14]. Another study in mice reported that C. papaya substances responsible for the release and/or production of thrombocytes [15].…”

Section: Animal Studiesmentioning

confidence: 99%

Carica Papaya; A Paired and Alternative Therapy of Dengue Fever

Nesar

Omer

Rizvi

et al. 2018

JBT

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show abstract

“…[13] Another study found that the C. papaya leaf aqueous extract at concentrations of 400 mg/kg and 800 mg/kg significantly increased the platelet counts in cyclophosphamide-induced thrombocytopenic rat model. It also reduced the clotting time in the treated rats.…”

Section: Studies In Animalsmentioning

confidence: 99%

Papaya extract to treat dengue: A novel therapeutic option?

Sarala¹,

Paknikar²

2014

Ann Med Health Sci Res

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Dengue is a viral disease that today affects a vast number of people in over 125 countries and is responsible for a sizable number of deaths. In the absence of an effective antiviral drug to treat the disease, various treatments are being investigated. Studies have indicated that the juice of the leaves of the Carica papaya plant from the family Caricaceae could help to increase the platelet levels in these patients. This review describes some of the published studies on this topic. The search was done independently by the two authors using PubMed, Google and the library database and included relevant articles of the last 10 years. A total of 7 studies were included in this review, which were one animal study, one case report, three case series and two randomized controlled trials. Although many of the studies and case reports published in literature lack adequate information, some of the studies do raise the possibility that this treatment could be an important option in the future. Further large-scale studies could establish the usefulness or ineffectiveness of this natural product in the treatment of dengue.

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“…A study was aimed to investigate the potential role of fresh Carica papaya leaf extract on hematological and biochemical parameters and toxicological changes in a murine model. 13 Fresh C. papaya leaf extract significantly increased the platelet and RBC counts in the test group as compared to controls. 15 Therefore, it is very important to identify those phytochemicals of C. papaya leaves as it can be recommended to be used as a medication to boost thrombopoiesis and erythropoiesis in humans and in animals in which these cell lineages have been compromised.…”

mentioning

confidence: 99%

“…12 The leaf is considered non-toxic as its lethal dose is >15 g/kg body weight. 13 Recent studies showed that C. papaya leaf extract has potential anti-sickling (inhibition of sickle cell formation) properties. 14 The capacity of papaya leaf extract to reverse the lowering of blood cells, especially platelets, is gaining attention in recent times.…”

mentioning

confidence: 99%

A post marketing randomized placebo controlled study to evaluate the efficacy of study product UPLAT® (Carica papaya leaf extract + Tinospora cordifolia extract) in the cancer patients with thrombocytopenia induced by chemotherapy

Tiwari¹,

Mandal²,

Patel³

2018

Int J Clin Trials

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Background: Thrombocytopenia refers to abnormal decrease in platelet count in an individual. The condition may rise at different grades of severity in cancer patients under chemotherapy. In most of the cases, thrombocytopenic condition of cancer patient becomes a major therapy limiting factor. Generally, the treatment of thrombocytopenia lies in dose reduction and/or dose delay but this may adversely affect the treatment plan of cancer. Therefore, managing chemotherapy induced thrombocytopenia is still a challenge. This study was conducted to examine the platelet count improving effect of marketed product UPLAT® (Carica papaya leaf extract + Tinospora cordifolia extract) in cancer patients with chemotherapy induced thrombocytopenia (CIT). Methods: Fourty (40) subjects were recruited as "case" and twenty (20) as "control". "Cases" were cancer patients with chemotherapy induced thrombocytopenia. UPLAT® containing following active ingredients; Carica papaya leaf extract: 350 mg (standardized to 2% flavonoids) and Tinospora cardifolia extract: 150 mg (standardized to 3% bitters) was given twice daily (2 units each) for 10 consecutive days. Platelet count was observed at baseline and day 15 (end of the study). Then pre and post-treatment platelet counts were compared individually in both arms by statistical tests. Response was evaluated in fourty (40) "cases" and twenty "control"y. Results: Mean change for platelet count in case group (93990.00±63896.73) was much higher than control group (27600.00±29758.42). No adverse events with the treatment were observed. Conclusions: This study proves the effectiveness of platelet booster UPLAT® (combination of Carica papaya leaf extract and Tinospora cordifolia) as it significantly increased thrombocytes/platelet count in post-chemotherapy cancer patients.

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Thrombocyte counts in mice after the administration of papaya leaf suspension

Cited by 43 publications

References 12 publications

Carica Papaya; A Paired and Alternative Therapy of Dengue Fever

Carica Papaya; A Paired and Alternative Therapy of Dengue Fever

Papaya extract to treat dengue: A novel therapeutic option?

A post marketing randomized placebo controlled study to evaluate the efficacy of study product UPLAT® (Carica papaya leaf extract + Tinospora cordifolia extract) in the cancer patients with thrombocytopenia induced by chemotherapy

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