Thrombocytopenia a predictor of malaria: how far?

Tiiba, Jamal-Deen I.; Ahmadu, Peter Uchogu; Naamawu, Alhassan; Fuseini, Memunatu; Raymond, Anecham; Osei-Amoah, Evelyn; Bobrtaa, Peter Claver; Bacheyie, Peter P.; Abdulai, Mohammed Adam; Alidu, Issah; Alhassan, Ahmed M.; Hamid, Jemilatu G. Abdul; Yussif, Abukari; Tayawn, Patricia Terekuu; Sakyi, Abigail Asantewaa; Yeng, Titus Naa; Aziz, Sanda A.; Mankana, Abdul-Hafiz; Husein, Wahab Abdulai; Abdallah, Abdul-Kudus W.; Mwininyaabu, Kpankpari Sylvanus; Kuffour, Martin Osei; Boateng, Esther Owusu; Owusu-Achiaw, Bernard; Eyulaku, Nkukar John

doi:10.1007/s12639-022-01557-4

Cited by 3 publications

(1 citation statement)

References 32 publications

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“…In our study 82.2% of patients that survive and 75.6% of the ones that died, presented thrombocytopenia at addition. In both, the survival group and the diseased, platelets counts decreased as parasitaemia increased (p<0,0001 and p=0,0417 respectively), corroborating other findings [35][36][37][38]. Hence we agree that thrombocytopenia is a marker of disease severity in adults with P. falciparum malaria, but has limited utility in prognostication, triage and management [37].…”

Section: Discussionsupporting

confidence: 84%

Severe Malaria in Angola: Clinical Profile and Disease Outcome among Adults from a Low-Endemic Area

Morais,

Rodrigues,

Mas

et al. 2024

Preprint

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Severe malaria is a major public health concern in Angola, particularly among adults, with limited data on clinical outcomes and manifestations. The study therefore assessed the clinical manifestations and outcome of severe Plasmodium falciparum malaria in adult patients admitted to Hospital Central Dr. António Agostinho Neto of Lubango, Angola. The study retrospectively reviewed the individual records of patients over 14 years old, admitted for severe malaria during the first trimester of 2021 and 2022. World Health Organization (WHO) criteria were used to define severity. A total of 640 patients were recorded into the study, 167 in 2021 and 473 in 2022, distributed across the departments; Intensive Care Unit (ICU; n=81), Medicine (MED; n=458) and Infectiology (INF; n=101). The median age was 26 years and 59.4% were males. The most common manifestation of severe malaria was renal impairment (37.4%). The overall mortality rate was 7% and decreased considerably from 10.2% in 2021 to 5.9% in 2022. The increase in malaria cases during 2022 with increased in prevalence of life-threatening signs like renal impairment, jaundice and impaired conscience, underscores the urgent need for enhanced malaria control and surveillance strategies to mitigate morbidity and mortality, highlighting the potential for antimalarial drug resistance.

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Section: Discussionsupporting

confidence: 84%

Severe Malaria in Angola: Clinical Profile and Disease Outcome among Adults from a Low-Endemic Area

Morais,

Rodrigues,

Mas

et al. 2024

Preprint

View full text Add to dashboard Cite

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Nigella sativa-Fortified Cookies Ameliorate Oxidative Stress, Inflammatory and Immune Dysfunction in Plasmodium berghei-Infected Murine Model

Ojueromi,

Oboh,

Ademosun

2024

Journal of Medicinal Food

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Severe Malaria in Angola: The Clinical Profile and Disease Outcome Among Adults from a Low-Endemic Area

Morais,

Rodrigues,

Mas

et al. 2024

Biomedicines

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Background/Objectives: Severe malaria poses a significant public health concern in Angola, particularly among adults. This study assessed the clinical manifestations and outcomes of severe Plasmodium falciparum malaria in adult patients admitted to Hospital Central Dr. António Agostinho Neto of Lubango (HCL), Angola. Methods: The study retrospectively reviewed medical records of patients over 14 years old admitted with severe malaria during the first quarter of 2021 and 2022, coinciding with the peak transmission season. The World Health Organization (WHO) criteria were used to clarify the disease severity. The cohort included 640 patients—167 in 2021 and 473 in 2022—distributed across the following departments: the Intensive Care Unit (ICU; n = 81), Medicine (MED; n = 458) and Infectiology (INF; n = 101). Results: The median age was 26 years and 59.4% were males. Renal impairment was the most frequent severe manifestation, affecting 37.4% of cases. The mortality rate across the study period was 7%, showing a notable decrease from 10.2% in 2021 to 5.9% in 2022. The higher mortality rate in 2021 may reflect the impact of the COVID-19 pandemic, which limited hospital access and delayed care, resulting in more critical cases being admitted at a later stage. In 2022, with reduced COVID-19 pressures, earlier access to treatment may have improved outcomes, contributing to the lower mortality rate. Conclusions: This study emphasizes the need to assess the clinical burden of severe malaria in low-endemic regions, where shifting patterns may signal emerging threats such as antimalarial drug resistance. Further research is essential to optimize control strategies and strengthen surveillance systems, reducing morbidity and mortality.

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Thrombocytopenia a predictor of malaria: how far?

Cited by 3 publications

References 32 publications

Severe Malaria in Angola: Clinical Profile and Disease Outcome among Adults from a Low-Endemic Area

Severe Malaria in Angola: Clinical Profile and Disease Outcome among Adults from a Low-Endemic Area

Nigella sativa-Fortified Cookies Ameliorate Oxidative Stress, Inflammatory and Immune Dysfunction in Plasmodium berghei-Infected Murine Model

Severe Malaria in Angola: The Clinical Profile and Disease Outcome Among Adults from a Low-Endemic Area

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