Thrombocytopenia, Anemia, and Retinal Hemorrhage

Rubenstein, Robert A.; Yanoff, Myron; Albert, Daniel M.

doi:10.1016/0002-9394(68)93098-5

Cited by 121 publications

(48 citation statements)

References 5 publications

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“…Other studies, which evaluated the thrombocytopenia and/or thrombocytosis influence on the occurrence of retinal changes, did not provide any definite clinical conclusion. 1,29 On the other hand, the reduction of the haematocrit reading is not always correlated either with an increased haemorrhagic predisposition 1,[28][29][30][31] or with greater retinal venous tortuosity. 32 The haematocrit reading of our thalassaemic patients was widely unstable, closely depending on the blood abstraction moment in comparison with transfusion timing.…”

Section: Discussionmentioning

confidence: 99%

Quantitative evaluation of the retinal venous tortuosity in chronic anaemic patients affected by β-thalassaemia major

Incorvaia

Parmeggiani

Costagliola

et al. 2003

Eye

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Aims Retinal venous tortuosity (RVT) is a common finding in patients affected by different forms of chronic anaemia. The aims of this study were to quantify RVT in anaemic patients with ß-thalassaemia major and to verify whether it is related to some of the following parameters: patient's age, ferritin plasma level, and Desferrioxamine (DFX) daily dosage. Methods A retrospective study was carried out. In total, 36 consecutive thalassaemic patients, treated with polytransfusion regimen and DFX, were age-and sex-matched with a control group of 36 normal subjects. All subjects bilaterally underwent red-free fundus photography, centred on the optic disc. The four main retinal veins were measured with a computer-assisted method. Results Mean venous length in the thalassaemic group was significantly greater than that observed in the control group (Po0.001). In thalassaemic patients, no significant correlations between retinal venous length and, respectively, plasma ferritin level and DFX daily dosage were documented. Statistical analysis demonstrated a very significant association between patient's age and increased RVT only in thalassaemic patients (Po0.001). Conclusions Our findings demonstrate that patients with b-thalassaemia major have increased RVT, as compared to normal subjects. In this selected anaemic population, patient's age, closely related to anaemia duration, is the only variable responsible for the RVT increment. This clinical sign indicates a long-standing duration of anaemia.

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Section: Discussionmentioning

confidence: 99%

Quantitative evaluation of the retinal venous tortuosity in chronic anaemic patients affected by β-thalassaemia major

Incorvaia

Parmeggiani

Costagliola

et al. 2003

Eye

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“…Severe vision loss can result from subretinal and intraretinal hemorrhage and residual serous retinal detachment following resorption of blood [3]. Thrombocytopenia alone rarely causes significant retinal or subretinal hemorrhage, but additional anemia can spawn hemorrhages [8, 14]. Shah et al [3] described bilateral subretinal and intraretinal hemorrhage associated with ITP in a previously healthy 26-year-old patient who subsequently developed an intracranial hemorrhage that required emergency neurosurgical intervention.…”

Section: Discussionmentioning

confidence: 99%

Suprachoroidal Hemorrhage Simulating Melanoma in Idiopathic Thrombocytopenic Purpura

2018

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Background: We report a case of suprachoroidal hemorrhage simulating choroidal melanoma in a patient with idiopathic thrombocytopenic purpura (ITP). Methods: Case report. Results: A 79-year-old white male with a history of lung adenocarcinoma, ITP, and mild anemia noted blurred vision with photopsia and floaters in the right eye (OD) that worsened over 2 months. He was found to have a pigmented choroidal mass and was referred for evaluation of possible choroidal melanoma. Visual acuity was 20/30 in the affected right eye and 20/25 in the left eye (OS). There was mild vitreous hemorrhage and 2 pigmented peripheral choroidal tumors in the temporal and nasal fundus OD. B-scan ultrasonography confirmed 2 acoustically hollow tumors, and transillumination demonstrated no shadowing. Optical coherence tomography over the lesions revealed choroidal elevation with suprachoroidal scalloped surface. Fluorescein and indocyanine green angiography revealed normal choroidal fluorescence and cyanescence with no “double circulation” of melanoma and no dye blockage, suggesting a suprachoroidal location. These findings were suggestive of suprachoroidal hemorrhage rather than melanoma. The patient was managed conservatively, and the hemorrhages demonstrated spontaneous resolution. Conclusion: Ocular manifestations of ITP are uncommon. Rarely, spontaneous suprachoroidal hemorrhage simulating melanoma can occur. A thorough clinical evaluation with multimodal imaging is critical to establishing the appropriate diagnosis.

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“…Rubenstein et al [17] demonstrated that retinal hemor rhage is much more likely to occur when anemia is accompanied by thrombocytope nia than when either is present alone. Our patient also had anemia, thrombocytopenia, and retinal hemorrhage.…”

Section: Discussionmentioning

confidence: 99%

Retinal Microaneurysms in a Patient with Drug-Induced Aplastic Anemia

Furuse¹,

Hayasaka²,

Yamamoto³

et al. 1987

Ophthalmologica

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We examined ophthalmologically a patient with drug-induced aplastic anemia. The patient had good visual acuity and full visual fields, but small round hemorrhages and small red dots were seen ophthalmoscopically in both fundi. Fluorescein angiography revealed punctate hyperfluorescence from the early to late phases, indicating microaneurysms. We believe that retinal microaneurysms are not rare in association with anemia.

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Thrombocytopenia, Anemia, and Retinal Hemorrhage

Cited by 121 publications

References 5 publications

Quantitative evaluation of the retinal venous tortuosity in chronic anaemic patients affected by β-thalassaemia major

Quantitative evaluation of the retinal venous tortuosity in chronic anaemic patients affected by β-thalassaemia major

Suprachoroidal Hemorrhage Simulating Melanoma in Idiopathic Thrombocytopenic Purpura

Retinal Microaneurysms in a Patient with Drug-Induced Aplastic Anemia

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