Thrombocytopenia as a Marker of Outcome in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease

Rahimi-Rad, Mohammad Hossein; Soltani, Sheida; Rabieepour, Masome; Rahimirad, Shagayegh

doi:10.5603/piap.2015.0056

Cited by 25 publications

(36 citation statements)

References 24 publications

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“…42 Clinically, eosinopenia has been suggested to be a prognostic marker for critically ill patients admitted to the Intensive Care Unit and those with COPD AE. [43][44][45] Both higher GPS and eosinopenia are representative of acute inflammation, and these factors were related with poor clinical outcomes in patients with IPF-AE in our study. Based on this finding, we suggest that inflammatory exacerbations of IPF are related to poor clinical outcomes.…”

Section: Discussionsupporting

confidence: 50%

“…During the acute stage of inflammation, rapid peripheral sequestration and migration of circulating eosinophils to the site of infection by cytokines and chemotactic substances results in eosinopenia . Clinically, eosinopenia has been suggested to be a prognostic marker for critically ill patients admitted to the Intensive Care Unit and those with COPD AE . Both higher GPS and eosinopenia are representative of acute inflammation, and these factors were related with poor clinical outcomes in patients with IPF‐AE in our study.…”

Section: Discussionmentioning

confidence: 99%

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Prognostic significance of Glasgow prognostic score in patients with acute exacerbation of idiopathic pulmonary fibrosis

et al. 2017

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Section: Discussionsupporting

confidence: 50%

Section: Discussionmentioning

confidence: 99%

Prognostic significance of Glasgow prognostic score in patients with acute exacerbation of idiopathic pulmonary fibrosis

et al. 2017

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“…Platelets play an important role in inflammation. Thrombocytopenia is associated with poor outcome in AECOPD and several other diseases (31)(32)(33)(34)(35). Association of lymphopenia with mortality has already shown in sepsis, in critically ill emergency general surgical patients, and heart failure (36,37).…”

Section: Discussionmentioning

confidence: 99%

Association between admission neutrophil to lymphocyte ratio and outcomes in patients with acute exacerbation of chronic obstructive pulmonary disease

Rahimirad¹,

Ghaffary²,

Rahimi-Rad³

et al. 2017

Tuberk Toraks

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Association between admission neutrophil to lymphocyte ratio and outcomes in patients with acute exacerbation of chronic obstructive pulmonary disease Introduction: The prognostic significance of neutrophil-to-lymphocyte ratio (NLR), derived-neutrophil-to-lymphocyte ratio (d-NLR), platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR) have been shown in many diseases. To the best of our knowledge, there is no published report evaluation of those parameters in acute exacerbation of chronic obstructive pulmonary disease (AECOPD). The aims of this study are to evaluate the parameters in predicting in-hospital mortality in patients with AECOPD. Materials and Methods: This is a retrospective study in two referral hospitals in Tabriz and Urmia, Iran. NLRs, PLR, LMR, and d-NLR were calculated from the admission day complete blood count of patients with AECOPD. Comparison was made between patients who died in hospital and those discharged alive. Results: Of 315 patients, 70 (22.2%) died in the hospital and 245 (77.8%) were discharged alive. The mortality rate was higher in patients with NLR ≥ 4 than with NLR < 4 (24% vs. 9.5% p value < 0.001). Multivariate analysis revealed NLR (p= 0.001) were independently associated with in-hospital mortality. NLR had the highest odds ratio for death both in univariate (OR= 3.80) and multivariate (OR= 3.50) analyses. The area under the receiver-operating characteristic curve for NLR in predicting in-hospital death was 0.72 (95% CI: 0.62-0.81; p< 0.001). PLR and LMR did not show significant relation to in-hospital death in AECOPD. Conclusion: This study shows for the first time that higher NLR is positively associated with in-hospital mortality in AECOPD.

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“…22 However, the effect of blood eosinophil in AECOPD outcomes remains controversial. Two studies found longer hospitalization, 23,24 a greater need for mechanical ventilation, 23 and increased mortality 23,24 in the group with eosinophilia. Further, a higher frequency of readmission for AECOPD 25 and a higher rate of exacerbations 26 have been found in those with eosinophilia.…”

Section: Introductionmentioning

confidence: 98%

<p>Peripheral Blood Eosinophil as a Biomarker in Outcomes of Acute Exacerbation of Chronic Obstructive Pulmonary Disease</p>

Wu¹,

Zhuo²,

Cheng³

2019

COPD

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Mounting evidence suggests that eosinophil levels correlate with the effects of therapy and phenotype for chronic obstructive pulmonary disease (COPD). This study aimed to clarify the relationship between eosinophil levels and clinical outcomes in patients with acute exacerbation of COPD (AECOPD). Methods: A prospective, multicenter, observational cohort study was performed in three teaching hospitals. Patients were grouped by quartile percentage (0, 0.7, 2.55) and absolute blood eosinophils count (0, 0.05×10 9 /L, 0.17×10 9 /L) and divided into four numbered groups ranked from low to high. Results: The study included 493 AECOPD patients. In the percentile-ranked groups, patients in Group 1 experienced significantly longer hospital stays, higher rates of both noninvasive mechanical ventilation (NIMV), and heart failure than those in Group 4 (12 days vs 10 days, p = 0.005; 29.5% vs 23.6%, p = 0.007; 48.4% vs 28.5%, p = 0.001). Group 1 also had higher frequencies of respiratory failure and pulmonary heart disease compared to Groups 3 and 4 (54.8% vs 34.8%, p = 0.002; 54.8% vs 35%, p = 0.003). In the absolute count-ranked groups, patients in Group 1 had significantly higher rates of NIMV than those in Group 3 (41.1% vs 21.7%, p = 0.001), had higher rates of heart failure, respiratory failure, and pulmonary heart disease than those in Group 3 and 4 (48.1% vs 30.2%, p = 0.003; 48.1% vs 30.4%, p = 0.005; 50.8% vs 32.2%, p = 0.004; 50.8% vs 34.1%, p = 0.008; 51.9% vs 34.1%, p = 0.004; 51.9% vs 33%, p = 0.003). There were outcome differences among the admitting hospital of stays in the absolute count groups (p = 0.002), but the differences were not significant in a pairwise comparison. The proportion of ICU admissions and mortality was different in two cohorts with no difference in a pairwise comparison. Conclusion: Patients with lower eosinophil counts experienced poorer clinical outcomes. Eosinophil levels may be a helpful marker to predict outcomes in AECOPD.

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Thrombocytopenia as a Marker of Outcome in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease

Cited by 25 publications

References 24 publications

Prognostic significance of Glasgow prognostic score in patients with acute exacerbation of idiopathic pulmonary fibrosis

Prognostic significance of Glasgow prognostic score in patients with acute exacerbation of idiopathic pulmonary fibrosis

Association between admission neutrophil to lymphocyte ratio and outcomes in patients with acute exacerbation of chronic obstructive pulmonary disease

<p>Peripheral Blood Eosinophil as a Biomarker in Outcomes of Acute Exacerbation of Chronic Obstructive Pulmonary Disease</p>

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