Thrombocytopenia associated with <i>Mycoplasma</i> pneumonia during pregnancy: Case presentation and approach for differential diagnosis

Nishikawa, Aiko; Mimura, Kazuya; Kanagawa, Takeshi; Maeda, Takeyasu; Tomimatsu, Takuji; Kimura, Tadashi

doi:10.1111/jog.12713

Cited by 6 publications

(7 citation statements)

References 8 publications

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“…[ 19 – 26 ] Patients with ITP coexisting with this infection often have refractory disease, and some of them have a poor prognosis. [ 19 – 24 ]…”

Section: Discussionmentioning

confidence: 99%

“…H. pylori infection associated with ITP was identified previously [18] . However, ITP secondary to M. pneumoniae infection was rarely reported, and primary HSV infection was reported in only 2 reports published decades ago [19–26] . Patients with ITP coexisting with this infection often have refractory disease, and some of them have a poor prognosis [19–24] …”

Section: Discussionmentioning

confidence: 99%

“…[18] However, ITP secondary to M. pneumoniae infection was rarely reported, and primary HSV infection was reported in only 2 reports published decades ago. [19][20][21][22][23][24][25][26] Patients with ITP coexisting with this infection often have refractory disease, and some of them have a poor prognosis. [19][20][21][22][23][24] However, whether the eradication of infections in patients with ITP effectively increases platelet counts is controversial.…”

Section: Discussionmentioning

confidence: 99%

“…[19][20][21][22][23][24][25][26] Patients with ITP coexisting with this infection often have refractory disease, and some of them have a poor prognosis. [19][20][21][22][23][24] However, whether the eradication of infections in patients with ITP effectively increases platelet counts is controversial. [27] Because the persistent thrombocytopenia may be the consequence of infections, we added azithromycin, valaciclovir, amoxicillin, clarithromycin, and PPI therapy.…”

Section: Discussionmentioning

confidence: 99%

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Immune thrombocytopenia associated with Hashimoto thyroiditis in a pediatric patient

et al. 2021

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Rationale: Immune thrombocytopenia (ITP) is one of the most commonly acquired bleeding diseases in children. Infection and autoimmune disorders are the most common causes of ITP. The pathogenic mechanism of ITP is complex and is not completely understood. Understanding the underlying causes or disorders of ITP will improve the prognosis and make therapy more targeted. Patient concerns: An 8-year-old girl with ITP responded poorly to first- and second-line treatment. The patient showed multiple scattered petechiae, ecchymoses, and purpura in the skin and blood clots in the oral mucous membrane. Diagnoses: The patient was diagnosed with ITP associated with Hashimoto thyroiditis. Interventions: The patient was admitted to our emergency department and received platelet transfusion, IVIG, glucocorticoids and eltrombopag. The patient's thrombocytopenia resolved within 18 days after the administration of levothyroxine treatment. Outcomes: The patient was diagnosed with Hashimoto thyroiditis, and the platelet count recovered on the 3rd day of levothyroxine treatment. The platelet count became steadily normal with levothyroxine and prednisone treatment within 2 months of follow-up. Lessons: Early identification of the underlying reasons and treatment with multiple modalities may be useful in improving the prognosis of ITP. The treatment of thyroid disease and restoration of the euthyroid state impact the clinical outcome of ITP in children.

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“…[ 19 – 26 ] Patients with ITP coexisting with this infection often have refractory disease, and some of them have a poor prognosis. [ 19 – 24 ]…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Immune thrombocytopenia associated with Hashimoto thyroiditis in a pediatric patient

et al. 2021

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“…However, certain associations between M. pneumoniae during pregnancy and hematological complications, such as hemolytic anemia, are among the most common pregnancy complications. Less frequently found are: thrombocytopenia, thrombotic thrombocytopenic purpura (TTP), DIC, aplastic anemia, hemophagocytosis, and transient acquired thrombin deficiency [ 190 ].…”

Section: Sars-cov-2 Zika and Mycoplasma Presentation During Pregnancy And Its Pathophysiological And Molecular Correlationsmentioning

confidence: 99%

Pathophysiological and molecular considerations of viral and bacterial infections during maternal-fetal and –neonatal interactions of SARS-CoV-2, Zika, and Mycoplasma infectious diseases

Ferreira

Blasina

Rey

et al. 2022

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseas

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During pregnancy, a series of physiological changes are determined at the molecular, cellular and macroscopic level that make the mother and fetus more susceptible to certain viral and bacterial infections, especially the infections in this and the companion review. Particular situations increase susceptibility to infection in neonates. The enhanced susceptibility to certain infections increases the risk of developing particular diseases that can progress to become morbidly severe. For example, during the current pandemic caused by the SARS-CoV-2 virus, epidemiological studies have established that pregnant women with COVID-19 disease are more likely to be hospitalized. However, the risk for intensive care unit admission and mechanical ventilation is not increased compared with nonpregnant women. Although much remains unknown with this particular infection, the elevated risk of progression during pregnancy towards more severe manifestations of COVID-19 disease is not associated with an increased risk of death. In addition, the epidemiological data available in neonates suggest that their risk of acquiring COVID-19 is low compared with infants (<12 months of age). However, they might be at higher risk for progression to severe COVID-19 disease compared with older children. The data on clinical presentation and disease severity among neonates are limited and based on case reports and small case series. It is well documented the importance of the Zika virus infection as the main cause of several congenital anomalies and birth defects such as microcephaly, and also adverse pregnancy outcomes. Mycoplasma infections also increase adverse pregnancy outcomes. This review will focus on the molecular, pathophysiological and biophysical characteristics of the mother/placental-fetal/neonatal interactions and the possible mechanisms of these pathogens (SARS-CoV-2, ZIKV, and Mycoplasmas) for promoting disease at this level.

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Thrombocytopenia associated with Mycoplasma pneumonia during pregnancy: Case presentation and approach for differential diagnosis

Cited by 6 publications

References 8 publications

Immune thrombocytopenia associated with Hashimoto thyroiditis in a pediatric patient

Immune thrombocytopenia associated with Hashimoto thyroiditis in a pediatric patient

Pathophysiological and molecular considerations of viral and bacterial infections during maternal-fetal and –neonatal interactions of SARS-CoV-2, Zika, and Mycoplasma infectious diseases

Prednisolone

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