Thrombocytopenia caused by low-dose heparin supplementation of parenteral nutrition solution

Lee, Eun-Young; Lee, Jeong-Ok; Lim, Yoojoo; Kim, Jiyeon; Kim, Hyun Kyung; Bang, Soo‐Mee

doi:10.5045/br.2013.48.2.160

Cited by 2 publications

(1 citation statement)

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“…Thrombotic events due to blood clotting are known to pose a serious problem in cardiovascular disease [45]. Although heparin (a protease inhibitor widely used to delay blood clotting time) has been widely used for this purpose, its continued use often results in the development of thrombocytopenia and immune response [46]. Furthermore, other anticoagulant drugs, such as aspirin and clopidogrel, may lead to serious side effects [47].…”

Section: Anticoagulant Activitymentioning

confidence: 99%

Purification and Characterization of a Novel Thermostable Papain Inhibitor from Moringa oleifera with Antimicrobial and Anticoagulant Properties

et al. 2021

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Plant cystatins (or phytocystatins) comprise a large superfamily of natural bioactive small proteins that typically act as protein inhibitors of papain-like cysteine proteases. In this report, we present the purification and characterization of the first phytocystatin isolated from Moringa oleifera (MoPI). MoPI has a molecular mass of 19 kDa and showed an extraordinary physicochemical stability against acidic pHs and high temperatures. Our findings also revealed that MoPI is one of the most potent cysteine protease inhibitors reported to date, with Ki and IC50 values of 2.1 nM and 5.7 nM, respectively. More interestingly, MoPI presents a strong antimicrobial activity against human pathogens such as Enterococcus faecalis and Staphylococcus aureus. In addition, MoPI also showed important anticoagulant activity, which is an unprecedented property for this family of protease inhibitors. These results highlight the pharmaceutical potential of this plant and its derived bioactive molecules.

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Section: Anticoagulant Activitymentioning

confidence: 99%