Thrombocytopenia during pregnancy in women with HIV infection receiving no treatment

Sebitloane, H.M.

doi:10.7196/samj.2016.v106i2.9903

Cited by 8 publications

(5 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The current finding was similar with different studies done in India (8.8%), 11 Iraq (8.0%), 32 Baghdad (7.1%), 33 Nigeria (13.5%), 20 and Libya (8.3%) 34 and other studies conducted in a different area of Ethiopia including Gondar, (8.8%), 35 Debre Berhan, (10.2%), 36 and Addis Ababa, (11.62%). 37 However, this finding was higher than the study done in South Africa (5.3%) 38 and lower than the studies conducted in China (28.2%), 22 Libya (18.0%), 39 and Ghana (15.3%). 40 The possible reason for the difference might be due to the differences in socioeconomic status, geographical variation, study population, availability and accessibility of health care facilities, health-seeking behaviors, a diagnostic method used, and differences in dietary habits of the study populations.…”

Section: Discussioncontrasting

confidence: 59%

Magnitude and Associated Factors of Thrombocytopenia among Pregnant Women Attending Antenatal Care Clinics at Dessie Comprehensive Specialized Hospital, Northeast Ethiopia

Ebrahim

Kebede²,

Tilahun

et al. 2022

Clin Appl Thromb Hemost

View full text Add to dashboard Cite

Background Thrombocytopenia is a common hematological abnormality during gestation. Pregnant women with severe thrombocytopenia may be associated with a higher risk of excessive bleeding during or after delivery. Therefore, the main aim of this study was to assess the magnitude and associated factors of thrombocytopenia among pregnant women attending antenatal care services at Dessie comprehensive and specialized hospital, Northeast Ethiopia. Methods An institution-based cross-sectional study was conducted from February to March 2021. Using a systematic random sampling technique, a total of 294 pregnant women were enrolled in the study. Structured interviewer-administered questionnaires were used to collect socio-demographic and clinical data of study participants. Four ml of venous blood were collected from each pregnant woman and a complete blood count was determined using DIRUI BF 6500 automated hematology analyzer. Data were entered into Epidata version 4.6.0 and then exported into SPSS version 24.0. Multivariate logistic regression was used to assess the association between dependent and independent variables. P-value < 0.05 was considered to be statistically significant. Results A total of 294 pregnant women who visited antenatal care services at Dessie comprehensive specialized hospital were included. The mean (±SD) age of the study participants was 29.7 (±6.1) years. The prevalence of thrombocytopenia among pregnant women was 9.9% (95% CI: 6.5, 13.6). A mild type of thrombocytopenia is the major type and accounted for 72.4% whereas moderate thrombocytopenia and severe thrombocytopenia accounted for 17.2% and 10.4% respectively among pregnant women. Multivariate logistic regression showed that urban residents (AOR: 0.206,95% CI, 0.055-0.748), gestational ages within the first trimester (AOR: 0.183, 95% CI, 0.057-0.593) and gestational ages within the second trimester (AOR = 0.264, 95% CI, 0.092-0.752) were significantly associated and independent predictors of thrombocytopenia in pregnant women. Conclusion In this study, the prevalence of thrombocytopenia was 9.9% and the mild type of thrombocytopenia (72.4%) was higher than the other type of thrombocytopenia among pregnant women. In multivariate logistic regression analysis, residence and gestational age (trimester) were significantly associated with thrombocytopenia. Therefore, the platelet count should be routinely determined during the antenatal care visit for proper diagnosis and to minimize bleeding during and or after childbirth.

show abstract

Section: Discussioncontrasting

confidence: 59%

Magnitude and Associated Factors of Thrombocytopenia among Pregnant Women Attending Antenatal Care Clinics at Dessie Comprehensive Specialized Hospital, Northeast Ethiopia

Ebrahim

Kebede²,

Tilahun

et al. 2022

Clin Appl Thromb Hemost

View full text Add to dashboard Cite

show abstract

“…2 Sebitloane conducted a retrospective analysis of a prospective trial (data collection 2005-2007) on 1 311 low-risk obstetric patients. 15 Enrolled patients were not receiving anti-retroviral treatment, as this was not standard of care at this time, and the overall incidence of mild thrombocytopenia was 5.3%, which is lower than the 10.3% in our study. This was likely due to the exclusion of pre-eclamptic patients in the Sebitloane study.…”

Section: Discussioncontrasting

confidence: 57%

Preoperative predictors of thrombocytopenia in Caesarean delivery: is routine platelet count testing necessary?

Nkomentaba

Bishop

Rodseth

2017

Southern African Journal of Anaesthesia and Analgesia

View full text Add to dashboard Cite

Peri-partum thrombocytopenia significantly impacts anaesthetic technique and increases the risk of perioperative bleeding. However, as less than 5% of normal pregnancies have significant thrombocytopenia, routine platelet testing incurs great cost for a relatively low yield. Determining whether clinical predictors, in particular HIV status, are associated with thrombocytopenia may assist clinicians in rationalising preoperative testing. Methods: This was a prospective, observational, single-centre study at a South African regional hospital. We evaluated five variables as candidate predictors for mild preoperative thrombocytopenia (< 150 000/μl) in patients scheduled for both elective and emergency Caesarean delivery: HIV status, pre-eclampsia, urgency of surgery, renal impairment and liver failure. As a subanalysis we compared the incidence of moderate thrombocytopenia (< 100 000/μl) in HIV-positive patients, with HIV-negative patients. Results:We recruited 1 015 patients to this study. The incidence of mild thrombocytopenia was 10.3% (105/1 015). Only preeclampsia was predictive of mild thrombocytopenia (odds ratio 3.51; p < 0.01; 95% confidence interval 2.12-5.82). The incidence of moderate thrombocytopenia was not influenced by HIV status (occurring in 1.5% of HIV-positive patients versus 1.8% in HIVnegative patients; p = 0.716). Conclusions: In this study of predominantly asymptomatic patients scheduled for Caesarean delivery, only pre-eclampsia was predictive of mild thrombocytopenia. In sub-analysis HIV status was not independently associated with moderate thrombocytopenia. All asymptomatic patients, including those who were HIV positive, had platelet counts > 70 000/μl.

show abstract

“…In our study, the prevalence of pregnancy-associated thrombocytopenia was 5.2%, which is lower in comparison to other studies. 8 , 9 , 21 Pregnancy-associated thrombocytopenia occurs in 6% – 10% of pregnant patients; however, its prevalence depends on its association with other medical conditions. 22 The diagnosis of gestational thrombocytopenia is a diagnosis of exclusion and accounts for the majority of all cases of thrombocytopenia during pregnancy.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and aetiology of moderate and severe thrombocytopenia in a tertiary and quaternary centre in KwaZulu-Natal

Jali

Nkambule

2020

Afr. J. Lab. Med.

View full text Add to dashboard Cite

Background Thrombocytopenia is a common haematological disorder, characterised by platelet counts below 150 × 10 9 /L. The aetiology of thrombocytopenia is multifactorial; notably, in a misdiagnosis this condition may be due to pre-analytical laboratory artefacts. Knowledge about the common aetiology of thrombocytopenia will assist clinicians in decision-making and interpretation of laboratory tests and this may lead to prompt, adequate patient management and cost-saving measures. Objective This study determined the prevalence and aetiology of moderate and severe thrombocytopenia in a tertiary or quaternary laboratory in Durban, KwaZulu-Natal, South Africa. Methods We conducted a retrospective study at the Inkosi Albert Luthuli Central Hospital haematology laboratory between October 2015 and April 2016. A total of 2076 full blood count results with a platelet count of less than 100 × 10 9 /L were retrieved from the Inkosi Albert Luthuli Academic Hospital database. Laboratory data were extracted and matched with clinical data and used to identify the potential aetiology of thrombocytopenia. Results The prevalence of thrombocytopenia was 14.9% within the selected study period. The haematology or oncology wards and clinic accounted for 55.2% of thrombocytopenia cases, whereas the adult and paediatric intensive care units accounted for 29.3%. Notably, 15.5% of thrombocytopenia cases were reported in non-haematology wards and clinics. The most common cause of thrombocytopenia was chemotherapy which accounted for 38.5% of all causes. Conclusion In our tertiary and quaternary setting, thrombocytopenia in adults was most common in patients admitted to haematology and oncology wards. Moreover, chemotherapy-induced thrombocytopenia accounted for more than a third of all these cases.

show abstract

Thrombocytopenia during pregnancy in women with HIV infection receiving no treatment

Cited by 8 publications

References 9 publications

Magnitude and Associated Factors of Thrombocytopenia among Pregnant Women Attending Antenatal Care Clinics at Dessie Comprehensive Specialized Hospital, Northeast Ethiopia

Magnitude and Associated Factors of Thrombocytopenia among Pregnant Women Attending Antenatal Care Clinics at Dessie Comprehensive Specialized Hospital, Northeast Ethiopia

Preoperative predictors of thrombocytopenia in Caesarean delivery: is routine platelet count testing necessary?

Prevalence and aetiology of moderate and severe thrombocytopenia in a tertiary and quaternary centre in KwaZulu-Natal

Contact Info

Product

Resources

About