2011
DOI: 10.3109/09537104.2011.607520
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Thrombocytopenia in childhood malaria with special reference toP. vivaxmonoinfection: A study from Bikaner (Northwestern India)

Abstract: Thrombocytopenia is commonly seen in Plasmodium vivax malaria, but its prognostic value has not been addressed in children. This prospective study included 676 admitted children of malaria [Plasmodium falciparum (Pf) monoinfection 262, Plasmodium vivax (Pv) monoinfection 380, and mixed (Pf + Pv) infection 34], in which thrombocytopenia (platelet count <150 × 10(3)/mm(3) on admission) was found in 442 (65.38%) children [Pf monoinfection 55.3% (145/262), Pv monoinfection 73.16% (278/380), and mixed infection 55.… Show more

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Cited by 34 publications
(47 citation statements)
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“…Other authors from India also reported significantly higher proportion of thrombocytopenia in P. vivax . [12, 13]. …”
Section: Discussionmentioning
confidence: 99%
“…Other authors from India also reported significantly higher proportion of thrombocytopenia in P. vivax . [12, 13]. …”
Section: Discussionmentioning
confidence: 99%
“…In a large prospective study from the Bikaner district of North India, they found thrombocytopenia in 73.16% (278/ 380) of children with P. vivax monoinfection, which was found to be significantly higher than either P. falciparum monoinfection [55.34%] or mixed infection [55.88%]. 11 The possible mechanisms for thrombocytopenia include direct lysis of platelets by P. vivax, immunological destruction by plateletassociated IgG antibody, and oxidative stress damage of thrombocytes.…”
Section: Discussionmentioning
confidence: 99%
“…In another study, out of the 17 patients affected by any of the WHO malaria severity criteria with confirmed monoinfection, 14 presented with thrombocytopenia, suggesting that this hematological complication can be explored as a marker of severity for P. vivax [19]. Tanwar et al in 2012 reported significant association of severe malaria with platelet count <2 lac/cumm in children [25]. Kochar et al in 2009 studied adult patients and reported all complications in patients with Plasmodium vivax malaria [26].…”
Section: Discussionmentioning
confidence: 99%