Thrombocytopenia in end-stage renal disease and chronic viral hepatitis B or C

Orășan, Olga Hilda; Urian, Laura; Ciulei, George; Breaban, Iulia; Stefan, Andreea Maria; Secara, Sorina Cezara; Taut, Adela Sitar; Sarlea, Simina Tarmure; Negrean, Vasile; Sampelean, Dorel; Paţiu, Ioan Mihai; Orășan, Remus; Cozma, Angela

doi:10.22543/7674.52.p236243

Cited by 4 publications

(5 citation statements)

References 25 publications

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“…Viral hepatitis (B or C) is another factor associated with thrombocytopenia in ESRD patients undergoing hemodialysis [35][36] . However, in our study, every patient received only heparin as an anticoagulant regimen, and patients with viral hepatitis (B or C) were excluded.…”

Section: Discussionmentioning

confidence: 99%

“…Although heparin-induced thrombocytopenia has been claimed to be associated with hemodialysis, according to some studies, the decreased platelet count was similar to the alternative anticoagulant regimen 34 . Viral hepatitis (B or C) is another factor associated with thrombocytopenia in ESRD patients undergoing hemodialysis 35 - 36 . However, in our study, every patient received only heparin as an anticoagulant regimen, and patients with viral hepatitis (B or C) were excluded.…”

Section: Discussionmentioning

confidence: 99%

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The spleen size in patients undergoing hemodialysis

Araújo

Suassuna

2021

Braz. J. Nephrol.

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Introduction: Inflammation promotes the progression of chronic renal failure, and the start of dialysis worsens inflammation. The enlargement of the spleen is associated with inflammation, and patients on hemodialysis may show a large spleen. The aim of the present study was to compare the spleen size of patients undergoing hemodialysis versus controls to update this thread. Methods: Controls and patients were eligible to participate in the study provided they were negative for serological markers of hepatitis B and C viruses and HIV, if they had no lymphoproliferative disorder, and if they were at least 18 years of age. Age, sex, and the duration of dialysis were recorded. Laboratory variables (hemoglobin, hematological cell count, serum creatinine) and the underlying cause of end-stage renal disease were analyzed. The spleen sizes of the patients were divided into tertiles. Results: The 75 controls and 168 patients selected were sex-matched. The patients were older, had larger spleens and lower platelet counts than controls. The relationship between spleen size and age in the controls and patients was quite similar. The patients in the first tertile of spleen size compared with those in the third were older and had a higher platelet counts. The underlying disease and dialysis vintage had no effect on spleen size. Discussion: The patients had larger spleens and a greater range of spleen sizes than the controls. In patients, the association between larger and smaller spleen with lower and higher platelet counts, respectively, sparked the speculation of occurrence of hypersplenism and hyposplenism.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The spleen size in patients undergoing hemodialysis

Araújo

Suassuna

2021

Braz. J. Nephrol.

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“…Dharmawan (2002) menyebutkan bahwa anemia makrositik hipokromik dapat terjadi karena adanya infeksi hemoprotozoa, anemia kongenital, gangguan koagulasi darah, dan terjadinya perdarahan yang banyak. Trombositopenia dapat disebabkan oleh penurunan produksi trombosit, peningkatan penghancuran trombosit atau penyerapan limpa (Orasan et al, 2018).…”

Section: Pembahasanunclassified

Unilateral Rhinitis and Hemobartonella Felis Infection in Domestic Cats With a History of Chronic Kidney Disease

Viria Xavier,

Devi Jayanti,

Made Krisna Erawan

2023

Vet.Sci.Med.J.

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Rhinitis is an inflammation of the mucous membranes of the nasal cavity, which can arise from a number of intranasal or systemic disorders. Hemobartonella felis is a gram-negative intracellular bacterium that attacks cat's erythrocytes. This treatment aims to discuss diagnostic and treatment techniques for rhinitis and Hemobartonellosis infection in cat with kidney failure. The animal is a local cat with a history of kidney failure, female, 6 years old and weighing 2.7 kg. The owner came with complaints of a serous discharge in the right nasal cavity and occasional sneezing. The cat has decreased appetite since 6 months and looks weak. Clinical examination showed swelling of the right mandibular lymph nodes and inspection of the oral cavity found gingivitis, tartar, and halitosis. Routine hematological examination results showed that the cat had macrocytic hypochromic anemia accompanied by thrombocytopenia. Examination of the blood smear preparations found coccoid formations with short chains or rod formations in the cat's erythrocytes which indicated a positive result for Hemobartonella felis. Case animal was diagnosed with unilateral rhinitis and Hemobartonella felis infection. The therapy given consisted of Doxycycline antibiotics at a dose of 10 mg/kg once a day for 14 days, anti-inflammatory Dexamethasone at a dose of 0.5 mg once a day for 5 days and Sangobion as a supportive therapy 1 capsule once a day for 10 days. The therapy given helps to improve the condition of the case animal. General check up of health conditions is required during the maintenance period.

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“…Hyaluronic acid (HA) was demonstrated to be useful for the detection of liver fibrosis in CHC patients, especially in cases where liver biopsy is restricted (such as end-stage renal disease) (24,25). CHC patients who responded to treatment with daclatasvir and asunaprevir had a lower value of HA at SVR compared to the baseline values (123 ± 43 vs. 71 ± 14 ng/mL, p<0.01), while nonrespondents showed no significant difference before and after the treatment (145 ± 43 vs. 172 ± 46 ng/mL, p = 0.465) (26).…”

Section: Serum Markers Of Liver Fibrosismentioning

confidence: 99%

The evaluation of liver fibrosis regression in chronic hepatitis C patients after the treatment with direct-acting antiviral agents – A review of the literature

Orășan¹,

Ciulei²,

Coste³

et al. 2019

JMMS

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The second-generation of direct-acting antiviral agents are the current treatment for chronic viral hepatitis C infection. To evaluate the regression of liver fibrosis in patients receiving this therapy, liver biopsy remains the most accurate method, but the invasiveness of this procedure is its major drawback. Different non-invasive tests have been used to study changes in the stage of liver fibrosis in patients with chronic viral hepatitis treated with the second-generation of direct-acting antiviral agents: liver stiffness measurements (with transient elastography or acoustic radiation force impulse elastography) or different scores that use serum markers to calculate a fibrosis score. We prepared a literature review of the available data regarding the long-term evolution of liver fibrosis after the treatment with direct-acting antiviral agents for chronic viral hepatitis C. Keywords  chronic viral hepatitis C, direct-acting antiviral agents, liver fibrosis Highlights ✓ Transient elastography is the routine investigation for liver fibrosis monitoring in patients with chronic viral hepatitis C treated with direct acting antiviral agents. ✓ The APRI and FIB-4 scores registered the highest decrease between the baseline and the end of the treatment in patients with chronic viral hepatitis C treated with direct acting antiviral agents.

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Thrombocytopenia in end-stage renal disease and chronic viral hepatitis B or C

Cited by 4 publications

References 25 publications

The spleen size in patients undergoing hemodialysis

The spleen size in patients undergoing hemodialysis

Unilateral Rhinitis and Hemobartonella Felis Infection in Domestic Cats With a History of Chronic Kidney Disease

The evaluation of liver fibrosis regression in chronic hepatitis C patients after the treatment with direct-acting antiviral agents – A review of the literature

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