Thrombocytopenia in pregnancy in a tertiary care hospital: a retrospective study

Varghese, Siby; Kour, Gagandeep; Dhar, Tapasya

doi:10.18203/2320-1770.ijrcog20161318

Cited by 5 publications

(11 citation statements)

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“…1,5,6,11 There were two (2%) maternal deaths in our study as compared to Nisha S 2 et al and Usha et al 11 where they reported 5.26% and 4.37% maternal mortality . One death was due to AFLP and another one was due to APLA.…”

Section: Fig 1: Severity Of Thrombocytopenia According To Etiologiesmentioning

confidence: 39%

Section: Fig 1: Severity Of Thrombocytopenia According To Etiologiesmentioning

confidence: 54%

“…5,6 There were 52% nulliparous and 48% multiparous women in our study. This finding is similar to Varghese S et al study 5 whereas in Parnas M et al study, majority of them were multiparous (78.1%). 6 In our study majority of women had moderate thrombocytopenia (49%) at the time of delivery, 26% had severe thrombocytopenia and 25% had mild thrombocytopenia this is in contrast to other studies where they observed mild to moderate thrombocytopenia during delivery time.…”

Section: Fig 1: Severity Of Thrombocytopenia According To Etiologiesmentioning

confidence: 54%

“…6 In our study majority of women had moderate thrombocytopenia (49%) at the time of delivery, 26% had severe thrombocytopenia and 25% had mild thrombocytopenia this is in contrast to other studies where they observed mild to moderate thrombocytopenia during delivery time. 2,5,9 The aim of management in these cases is to achieve and maintain a 'safe' rather than normal platelet count. An experienced team and an individualized approach are important.…”

Section: Fig 1: Severity Of Thrombocytopenia According To Etiologiesmentioning

confidence: 99%

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Prevalence of thrombocytopenia in Parturient: Experience in Tertiary Care Center

2020

IJOGR

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Introduction: Thrombocytopenia can result from a wide range of conditions with several of them being pregnancy related. Obstetricians manage most cases of pregnancy-associated thrombocytopenia. Thus, a working knowledge of the clinical features and management of thrombocytopenia in pregnant women is important. The objective of the study was to evaluate the causes of thrombocytopenia and its effect on maternal and neonatal outcome in parturient women and also evaluate the obstetric risk factors, complications, and outcome of pregnancies complicated by thrombocytopenia. Materials and Methods: A prospective study of 100 antenatal women with thrombocytopenia who delivered at St John's Medical College Hospital during a one and a half year period. The blood samples of pregnant women in labor room were collected at the time of admission. These women were followed up till they deliver. Results:The main causes of thrombocytopenia were hypertensive disorders: preeclampsia (15%), Hemolysis, elevated liver enzymes, and low platelets (24%) and eclampsia (4%); idiopathic thrombocytopenic purpura (16%), gestational thrombocytopenia (11%). Women with hypertensive disorders had higher rates of cesarean delivery (65%), intrauterine growth restriction (30%) and preterm deliveries (31%). Hemorrhagic complications are common in rarer causes of thrombocytopenia. Conclusion:The adverse outcome is specifically attributed to preeclampsia, HELLP syndrome and rare causes. While the perinatal outcome of GT and ITP is basically favorable. Careful surveillance is required for these women in high-risk units for early detection and treatment of possible complications, in order to reduce adverse maternal and neonatal outcomes.

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Section: Fig 1: Severity Of Thrombocytopenia According To Etiologiesmentioning

confidence: 39%

Section: Fig 1: Severity Of Thrombocytopenia According To Etiologiesmentioning

confidence: 54%

Section: Fig 1: Severity Of Thrombocytopenia According To Etiologiesmentioning

confidence: 54%

Section: Fig 1: Severity Of Thrombocytopenia According To Etiologiesmentioning

confidence: 99%

See 2 more Smart Citations

Prevalence of thrombocytopenia in Parturient: Experience in Tertiary Care Center

2020

IJOGR

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“…1 There is significant contribution of infective and vector disease causing thrombocytopenia which was apparently absent in the studies from western countries. 17 Thus, it appears that with different study populations even in Indian scenario, the causes could be different and may be due to regional influence; hence, a multi-centric study with larger sample size is necessary.…”

Section: Discussionmentioning

confidence: 99%

Thrombocytopenia in Pregnancy Nearing Term: A Clinical Analysis

Harde

Bhadade

deSouza

et al. 2019

Indian Journal of Critical Care Medicine

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Background and aimThrombocytopenia in pregnancy varies from benign to severe with fetomaternal complications. We aimed to evaluate thrombocytopenia in pregnant Indian females in third trimester mainly during labor and delivery.Materials and methodsIt was a prospective observational study done in a tertiary care teaching public hospital over 1 year. Consecutive 150 pregnant patients admitted to labor ward with thrombocytopenia were analyzed for etiology of thrombocytopenia, severity, mode of delivery, type of anesthesia, and fetomaternal complications. SPSS version 17 was used for the analysis.ResultsMost common cause of thrombocytopenia was preeclampsia 50 (33.3%) and preeclampsia with hemolysis, elevated liver enzyme, and low platelet count syndrome (HELLP syndrome) 31 (20.7%) together followed by gestational 42 (28%). Infectious causes such as malaria, dengue, and leptospirosis were found in 19 patients (12.7%). Moderate to severe thrombocytopenia was seen in preeclampsia, preeclampsia with HELLP syndrome, and infectious etiology. Eleven patients (7.3%) developed antepartum hemorrhage (APH), 24 (16%) postpartum hemorrhage (PPH), 12 (8%) required ICU admission, and 3 (2%) mortalities were noted. Fifteen neonates (10%) needed ICU admission. Complications were observed in preeclampsia with HELLP syndrome (82%) and infectious causes (18%) and none in gestational. Sixty-eight patients underwent lower segment cesarean section (LSCS), among them 41 (27.3%) were given spinal anesthesia (SA) and none of them developed any neurological complications.ConclusionStudy widened the spectrum of causes for thrombocytopenia in pregnant patients. Preeclampsia with or without HELLP syndrome and vector-borne infections such as malaria, dengue, and leptospirosis were found to be very important causes of moderate to severe thrombocytopenia and were associated with complications. Spinal anesthesia is safe in parturients with mild thrombocytopenia. Awareness and vigilance about thrombocytopenia is vital to reduce maternal morbidity and mortality.How to cite this articleHarde M, Bhadade R, deSouza R, Jhingan M. Thrombocytopenia in Pregnancy Nearing Term: A Clinical Analysis. IJCCM 2019;23(11):503–508.

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Thrombocytopenia and associated factors among pregnant women attending antenatal care at Hiwot Fana Comprehensive Specialized Hospital, Eastern Ethiopia: A cross-sectional study

Arkew,

Asmerom,

Sileshi

et al. 2024

Medicine

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Thrombocytopenia (TCP) is the second most common hematological change during pregnancy and is considered as a major source of maternal and neonatal morbidity and mortality. Despite its effects to morbidity and mortality, it is frequently ignored or disregarded, particularly in resource-limited nations. Thus, the purpose of this study was to determine the prevalence of thrombocytopenia and associated factors among pregnant women attending antenatal care at Hiwot Fana Comprehensive Specialized University Hospital, Eastern Ethiopia from June 20 to August 30, 2022. A hospital-based cross-sectional study was conducted among 199 pregnant women selected through a systematic sampling technique. Ethical approval was obtained from the Ethics Review Committee of Haramaya University. Data related to sociodemographic and reproductive variables were collected using structured questionnaires. Four milliliters of venous blood were collected from each study participant and a complete blood cell count was determined using UniCel DxH 800 hematology analyzer. Logistic regression analysis was done to assess the association between TCP and independent variables and P < .05 was considered statistically significant. In this study, the prevalence of TCP was 14.1% (95% CI: 9.6–19.7). Of them, 10 (35.7%), 12 (42.9%), and 4 (21.4%) had mild, moderate, and severe TCP, respectively. Having more than 3 children (adjusted odds ratio, AOR = 7.90, 95% CI: 2.60, 24.3), no antenatal care follow-up (AOR = 7.90, 95% CI: 2.40–26.2), being in the second and third trimester (AOR = 6.90, 95% CI: 1.70, 28.9 and AOR = 5.04, 95% CI: 1.12, 22.7, respectively), and history of heavy menstrual bleeding (AOR = 4.03, 95% CI: 1.25, 13.1) were significantly associated with TCP. TCP is a public health problem among pregnant women in the study area. Having more than 3 children, lack of antenatal care follow-up, being in the second and third trimesters, and having history of heavy menstrual bleeding was significantly associated with TCP. As a result, regular platelet count monitoring and appropriate intervention approaches based on identified predictors should be explored to mitigate adverse outcomes in pregnant women.

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Thrombocytopenia in pregnancy in a tertiary care hospital: a retrospective study

Cited by 5 publications

References 5 publications

Prevalence of thrombocytopenia in Parturient: Experience in Tertiary Care Center

Prevalence of thrombocytopenia in Parturient: Experience in Tertiary Care Center

Thrombocytopenia in Pregnancy Nearing Term: A Clinical Analysis

Thrombocytopenia and associated factors among pregnant women attending antenatal care at Hiwot Fana Comprehensive Specialized Hospital, Eastern Ethiopia: A cross-sectional study

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