Thrombocytopenia: the most frequent haemostatic disorder in the ICU

Pluta, Jan; Trzebicki, Janusz

doi:10.5603/ait.2019.0011

Cited by 14 publications

(11 citation statements)

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“…Although not found in our study, pseudothrombocytopenia (PTCP) is a rare laboratory artifact with an estimated population incidence of 0.1-2% [1]. In PTCP, the reduction of PLT count below the lower range limit in a patient without symptoms of hemorrhagic diathesis results from the action of autoantibodies related to the presence of EDTA in the test tube, which causes platelets agglutination.…”

Section: Discussionmentioning

confidence: 51%

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Thrombocytopenia in critically ill patients: single center data analysis

et al. 2022

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Section: Discussionmentioning

confidence: 51%

“…Thrombocytopenia (TP), usually defined as a decreased number of platelets (PLT) below 150 × 10 9 /L, is one of the most frequent hemostatic abnormalities found in laboratory tests in critically ill patients [1]. PLT counts of greater than 50 × 10 9 /L are generally not associated with clinical symptoms.…”

Section: Introductionmentioning

confidence: 99%

Thrombocytopenia in critically ill patients: single center data analysis

et al. 2022

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“…It has been known that mortality increases as platelet count decreases. Abnormal platelet count is quite common in patients in the intensive care unit [ 35 ]. In this concern, Lippi et al, found that the rate of thrombocytopenia below the lower limit of the locally defined reference range was associated with an over fivefold enhanced risk of severe COVID-19 [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

Association between thrombocytopenia and the severity of Covid-19 infection among hospitalized Egyptian patients

El-Khaiat

El-Lehlah

Kesheita

et al. 2022

Annals of Medicine &Amp; Surgery

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“…An elevation of CRP reflects an activation of immune responses which are often triggered by infections in critically ill patients leading to worse outcome [11]. Thrombocytopenia is the most common hemostatic disorder in patients admitted to ICUs [12]. Mechanisms contributing to a decrease in platelet count in critically ill patients are multifactorial, among which sepsis and trauma are the most frequent.…”

Section: Discussionmentioning

confidence: 99%

“…Mechanisms contributing to a decrease in platelet count in critically ill patients are multifactorial, among which sepsis and trauma are the most frequent. A low platelet count is a strong independent predictor of morbidity and mortality as it is associated with life-threatening bleeding or thrombosis [12]. Non-responders to endoscopic therapy also showed elevated serum lactate levels 14 days after tube placement.…”

Section: Discussionmentioning

confidence: 99%

Endoscopic decompression of acute intestinal distension is associated with reduced mortality in critically ill patients

et al. 2020

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Background: Endoscopic placement of intestinal decompression tubes is a feasible technique for treatment of acute intestinal dilation. Given the heterogeneity of the underlying diseases leading to intestinal obstruction data on the significance of endoscopic procedures for treatment of these conditions are sparse. Methods: In the study period from 2008 to 2019 all patients receiving a decompression tube were identified by retrospective chart review and analyzed. Results: A total of 59 decompression tubes were placed in 50 patients. Technical success was achieved in 98% (58/ 59 tubes). As major complication one small bowel perforation occurred (1/59; 1.7%). Causes for impaired intestinal transit comprised tumor stenoses 22% (11/50), infections 18% (9/50), post-operative paralysis 14% (7/50), neurological diseases 8% (4/50), trauma 2% (1/50) and others 36% (18/50). Most patients (74%; 37/50) were critically ill and treated on intensive care unit. Treatment response after tube insertion was documented in 76% of patients (38/50) whereas 24% (12/50) did not fulfill response criteria. Patients with treatment response showed a significantly better outcome compared to non-responders. Responders had a median survival of 113 days (95% CI 41-186) compared to 15 days (95% CI 6-24) in non-responders (p = 0.002). Analysis of laboratory parameters after stratification in responders and non-responders to endoscopic therapy showed that non-responders had significantly higher levels of CRP and lower platelet count at baseline (CRP 262 mg/L (IQR 101-307) vs. 94 mg/L (IQR 26-153): p = 0.027; platelets 69 thsd/μL : p = 0.009).Conclusions: Endoscopic decompression is a safe procedure for acute management of impaired intestinal transit even in critically ill patients. Response to therapy is associated with improved outcome and markers of inflammation and organ function such as CRP, platelet count and serum lactate have to be taken into account for therapy monitoring and evaluation of prognosis.

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Thrombocytopenia: the most frequent haemostatic disorder in the ICU

Cited by 14 publications

References 0 publications

Thrombocytopenia in critically ill patients: single center data analysis

Thrombocytopenia in critically ill patients: single center data analysis

Association between thrombocytopenia and the severity of Covid-19 infection among hospitalized Egyptian patients

Endoscopic decompression of acute intestinal distension is associated with reduced mortality in critically ill patients

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