2005
DOI: 10.1002/ajh.20408
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Thrombocytopenic conditions—autoimmunity and hypercoagulability: Commonalities and differences in ITP, TTP, HIT, and APS

Abstract: Immune thrombocytopenia purpura (ITP), thrombotic thrombocytopenia purpura (TTP), heparin‐induced thrombocytopenia (HIT), and antiphospholipid syndrome (APS) are clinical conditions associated with significant morbidity and mortality. These well‐defined clinical syndromes have in common several properties: (1) their pathogenesis is immune mediated, specifically by autoantibodies; (2) thrombocytopenia is a hallmark in these four conditions; (3) except for the case of ITP, platelet and endothelial cell activatio… Show more

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Cited by 41 publications
(25 citation statements)
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“…Inherited hemoglobin disorders are the most common monogenic disease worldwide with an estimated 7% of the global population being carriers for such disorders [1][2][3]. One severe form of hemoglobin disorder is thalassemia major, which typically presents in the first year of life with severe anemia and requires life-long red blood cell transfusions every 3-4 weeks [4].…”
Section: Introductionmentioning
confidence: 99%
“…Inherited hemoglobin disorders are the most common monogenic disease worldwide with an estimated 7% of the global population being carriers for such disorders [1][2][3]. One severe form of hemoglobin disorder is thalassemia major, which typically presents in the first year of life with severe anemia and requires life-long red blood cell transfusions every 3-4 weeks [4].…”
Section: Introductionmentioning
confidence: 99%
“…These include: circulating antibodies or antigen-antibody complexes caused by the primary autoimmune disorder and inducing endothelial dysfunction [9]; platelet damage by TTP and production of autoantibodies [4]; deficiency of Von-Willebrand factor cleaving protease activity [10] or autoantibody against VWF cleaving protease [11]; molecular mimicry or redundancy of the immune system, also known as the kaleidoscope of immunity, which is the co-occurrence of various autoimmune diseases within an individual [12]. …”
Section: Discussionmentioning
confidence: 99%
“…cAPS shares several features with MHAs. As an example, a common feature among cAPS, TTP and an additional entity, the heparin-induced thrombocytopenia (HIT), is the presence of antibody-mediated thrombosis [51]. Otherwise, another entity, the idiopathic thrombocytopenic purpura (ITP), is also characterized by the presence of autoantibodies reacting with platelet-specific antigens resulting in thrombocytopenia as well [52].…”
Section: Microangiopathic Anemia and Thrombocytopenia In Capsmentioning
confidence: 98%