Thrombocytosis in Under-Five Children with Lower Respiratory Tract Infection

Choudhury, Jasashree; Rath, Debasmita

doi:10.5812/pedinfect.61605

Cited by 3 publications

(5 citation statements)

References 17 publications

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“…MPV and PDW are two key platelet markers associated with inflammation. MPV and PDW levels in pneumonia patients were lower than in the control group in our study, as previously reported (2,(27)(28)(29)(30). The level of MPV was reported to decrease with the severity of the pneumonia however we did not find an association between MPV and CAP severity.…”

Section: Discussionsupporting

confidence: 70%

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The diagnostic value of complete blood parameters in determining the severity of community-acquired pneumonia in children

Güven

Kışlal²

2022

Journal of Health Sciences and Medicine

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Aim: In children, community-acquired pneumonia (CAP) has a high mortality and morbidity rate. Platelet, neutrophil, lymphocyte, monocyte, eosinophil, red cell distributions width (RDW), mean platelet volume (MPV), platelet distributions width (PDW), platelet to lymphocyte ratio (PLR), and neutrophil to lymphocyte ratio (NLR) have all been suggested as markers of systemic infection and inflammation. Several research, however, have centered on the clinical significance of blood parameters in pediatric CAP. We aim to determine the diagnostic value of complete blood parameters for CAP and to look into their relationship to disease severity. Material and Method: A retrospective, the cross-sectional study enrolled children aged 3 months to 18 years who were diagnosed with CAP at Ankara Atatürk Sanatorium Training and Research Hospital's pediatrics clinics between January 2018 and June 2021, as well as age-matched healthy children. CAP case definition was made according to the CAP case definition defined by the World Health Organization (WHO). Patients were evaluated according to the criteria of WHO and British Thoracic Society 2011 guidelines as severe and mild CAP. Results: 400 CAP and 400 control patients were included in the study. The mean age of the CAP group was 2.40±3.20 years and the control group was 2.38±3.17 years. Eosinophil, hemoglobin, MPV, PDW and PLR values of the CAP group was statistically significantly lower; leukocytes, lymphocyte, monocyte, neutrophil, basophil, platelet, RDW, and NLR levels of the CAP group were higher than the control group (p

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Section: Discussionsupporting

confidence: 70%

“…Platelets are essential inflammation cells that generate a big portion of cytokines and also can behave as acute phase reactants as well. Platelet counts were reported to be higher in children with pneumonia (27,28).…”

Section: Discussionmentioning

confidence: 97%

The diagnostic value of complete blood parameters in determining the severity of community-acquired pneumonia in children

Güven

Kışlal²

2022

Journal of Health Sciences and Medicine

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“…For example during respiratory tract infection, there are increasing levels of inflammatory cytokines which heightens the production of thrombocytes. 33 In contrast, thrombocytopenia was observed by 8% (95% CI: 4.59–11.34). The decrement of platelet count in the current study was in agreement with previous studies.…”

Section: Discussionmentioning

confidence: 96%

“… 32 Thrombocytosis is another hematological alteration in undernourished children that could be associated with infection. 33 In Ethiopia, undernutrition is a major public health problem and a preliminary diagnosis in 20% of pediatric hospital admissions. 34 The fatal effect of the disease in relation to hematological features is one concern where attentions have not yet got.…”

Section: Introductionmentioning

confidence: 99%

<p>Hematological Abnormalities and Associated Factors Among Undernourished Under-Five Children Attending University of Gondar Specialized Referral Hospital, Northwest Ethiopia</p>

Getawa

Getaneh

Melku

2020

JBM

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Introduction The hematopoietic system is one of the systems which can be affected by malnutrition, leading to impaired production of all blood cell lines. Undernourished children with hematological abnormalities like anemia are at higher risk of mortality. Therefore, this study aimed at determining the magnitude and associated factors of hematological abnormalities among undernourished under-five children attending at the University of Gondar Specialized Referral Hospital, Northwest Ethiopia. Methods and Materials An institution-based cross-sectional study was conducted on a total of 251 undernourished under-five children at University of Gondar Specialized Referral Hospital from January to May 2020. A convenient sampling technique was employed to select study participants. Data were collected using a pretested structured questionnaire. Blood samples were collected for complete blood count which were determined by Sysmex KX-21N analyzer. Stool sample was processed via direct wet mount. Thin and thick blood films were examined to assess malaria parasite. The data were entered to EpiData version 4.6.0.0 and analyzed using SPSS version 23 software. Bi-variable and multi-variable binary logistic regression model were fitted to identify factors associated with hematological abnormalities. A p-value <0.05 in the multivariable analysis was considered as statistically significant. Results The overall magnitude of anemia, leukocytosis, thrombocytosis, thrombocytopenia, and leukopenia was 53.4%, 26.7%, 23.9%, 8%, and 2.8%, respectively. Being male, age 6–23 months, high birth order, intestinal parasite infection, edema, not eating vegetables and fruits, and paternal occupation were found to be associated with anemia. Only the age of a child was associated with leukocytosis in undernourished children. Conclusion The current study demonstrated the predominant existence of anemia, leukocytosis, and thrombocytosis among undernourished under-five children. Therefore, early diagnosis, monitoring and setting intervention strategies for anemia especially among children under two years old are required to prevent further complication.

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“…6 Platelet count elevated more than normal is often sign of severe pneumonia according to various studies. 7…”

Section: Introductionmentioning

confidence: 99%

Thrombocytosis: a predictor of severity in children with lower respiratory tract infection

Chandrakala¹,

Patil²,

Kavya³

et al. 2021

Int J Contemp Pediatr

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Background: Community acquired pneumonia remains a significant cause of morbidity and mortality due to infection all over the world. Thrombocytes are known to be an essential part of immune response to various infectious agents. Platelet count elevated more than normal is often sign of severe pneumonia according to various studies.Methods: This is a retrospective study conducted in Kempegowda Institute of Medical Science, a tertiary care hospital in Bangalore with a study duration of 1 year. All children were classified into two groups based on platelet count that is with thrombocytosis and without thrombocytosis. Respiratory distress was defined as presence of tachypnoea, chest retractions, oxygen saturation <94% in room air. Children with respiratory distress were classified as severe pneumonia and those with no respiratory distress as non-severe pneumonia.Results: A total of 213 children were admitted with lower respiratory tract infection of which 35 children were excluded based on exclusion criteria. Of these 178 children 142 (80%) belonged to non-severe pneumonia group and 36 (20%) belonged to severe pneumonia group. Thrombocytosis is found in 31 (17%) children, 147 (82%) children had platelet count less than 4.5 lakhs/cu mm. Of these children with thrombocytosis 13 (42%) had non severe pneumonia and 18 (58%) had severe pneumonia. The p<0.0000001 which showed statistical significance, that is thrombocytosis was significantly associated with severity of pneumonia.Conclusions: Thrombocytosis can be considered as a marker of severity of pneumonia in day-to-day practice.

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Thrombocytosis in Under-Five Children with Lower Respiratory Tract Infection

Cited by 3 publications

References 17 publications

The diagnostic value of complete blood parameters in determining the severity of community-acquired pneumonia in children

The diagnostic value of complete blood parameters in determining the severity of community-acquired pneumonia in children

<p>Hematological Abnormalities and Associated Factors Among Undernourished Under-Five Children Attending University of Gondar Specialized Referral Hospital, Northwest Ethiopia</p>

Thrombocytosis: a predictor of severity in children with lower respiratory tract infection

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