Thromboelastography evaluation of low response to clopidogrel in patients with acute coronary syndrome

Zhao, Lijia; Xu, Xiaowei; Du, Fang; Chen, Buxing

doi:10.1016/j.ijge.2017.07.007

Cited by 1 publication

(1 citation statement)

References 21 publications

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“…VHA measurements of platelet function and hemostasis factors are demonstrated as risk predictors of ischemia and bleeding in patients undergoing percutaneous coronary intervention (PCI) [67][68][69], and have shown a correlation with disease severity in patients with cardiovascular diseases [70][71][72][73]. The addition of platelet function assays to treatment algorithms in the presence of aspirin or a P2Y 12 receptor inhibitor further allows clinicians to monitor antiplatelet therapy and individualize both the medication type and the dose [66,[74][75][76][77][78][79][80][81][82][83][84][85]. VHAs have been used to explore the efficacy and safety of antiplatelet therapies, including aspirin [64], clopidogrel [86], cangrelor [87], and the direct oral anticoagulant such as dabigatran [88].…”

Section: Interventional Cardiologymentioning

confidence: 99%

The role of viscoelastic testing in assessing peri-interventional platelet function and coagulation

et al. 2021

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We carried out a literature search in MEDLINE (PubMed) and EMBASE literature databases to provide a concise review of the role of viscoelastic testing in assessing peri-interventional platelet function and coagulation. The search identified 130 articles that were relevant for the review, covering the basic science of VHA and VHA in clinical settings including cardiac surgery, cardiology, neurology, trauma, non-cardiac surgery, obstetrics, liver disease, and COVID-19. Evidence from these articles is used to describe the important role of VHAs and platelet function testing in various peri-interventional setups. VHAs can help us to comprehensively assess the contribution of platelets and coagulation dynamics to clotting at the site-of-care much faster than standard laboratory measures. In addition to standard coagulation tests, VHAs are beneficial in reducing allogeneic transfusion requirements and bleeding, in predicting ischemic events, and improving outcomes in several peri-interventional care settings. Further focused studies are needed to confirm their utility in the peri-interventional case.

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