Thromboelastography in obese horses with insulin dysregulation compared to healthy controls

Lovett, Amy L; Gilliam, Lyndi L.; Sykes, B. W.; McFarlane, Dianne

doi:10.1111/jvim.16421

Cited by 4 publications

(1 citation statement)

References 46 publications

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“…Obesity in horses has been associated with metabolic alterations and diseases, including insulin resistance [ 22 ], alterations of adipose tissue and cardiovascular function [ 23 , 24 ], low-grade inflammation [ 25 ] and weakened immunity [ 26 ], equine metabolic syndrome [ 27 ], and laminitis [ 28 ], as well as changes in the composition [ 29 ] and function [ 30 ] of the gut microbiota. Obesity can also negatively impact sports performances [ 31 ], as well as the physiological response to exercise and locomotion symmetry [ 32 ].…”

Section: Introductionmentioning

confidence: 99%

Obesity during Pregnancy in the Horse: Effect on Term Placental Structure and Gene Expression, as Well as Colostrum and Milk Fatty Acid Concentration

Robles,

Rousseau-Ralliard,

Dubois

et al. 2023

Veterinary Sciences

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In horses, the prevalence of obesity is high and associated with serious metabolic pathologies. Being a broodmare has been identified as a risk factor for obesity. In other species, maternal obesity is known to affect the development of the offspring. This article is a follow-up study of previous work showing that Obese mares (O, n = 10, body condition score > 4.25 at insemination) were more insulin resistant and presented increased systemic inflammation during pregnancy compared to Normal mares (N, n = 14, body condition score < 4 at insemination). Foals born to O mares were more insulin-resistant, presented increased systemic inflammation, and were more affected by osteoarticular lesions. The objective of the present study was to investigate the effect of maternal obesity on placental structure and function, as well as the fatty acid profile in the plasma of mares and foals, colostrum, and milk until 90 days of lactation, which, to our knowledge, has been poorly studied in the horse. Mares from both groups were fed the same diet during pregnancy and lactation. During lactation, mares were housed in pasture. A strong heat wave, followed by a drought, occurred during their 2nd and 3rd months of lactation (summer of 2016 in the Limousin region, France). In the present article, term placental morphometry, structure (stereology), and gene expression (RT-qPCR, genes involved in nutrient transport, growth, and development, as well as vascularization) were studied. Plasma of mares and their foals, as well as colostrum and milk, were sampled at birth, 30 days, and 90 days of lactation. The fatty acid composition of these samples was measured using gas chromatography. No differences between the N and O groups were observed for term placental morphometry, structure, or gene expression. No difference in plasma fatty acid composition was observed between groups in mares. The plasma fatty acid profile of O foals was more pro-inflammatory and indicated an altered placental lipid metabolism between birth and 90 days of age. These results are in line with the increased systemic inflammation and altered glucose metabolism observed until 18 months of age in this group. The colostrum fatty acid profile of O mares was more pro-inflammatory and indicated an increased transfer and/or desaturation of long-chain fatty acids. Moreover, O foals received a colostrum poorer in medium-chain saturated fatty acid, a source of immediate energy for the newborn that can also play a role in immunity and gut microbiota development. Differences in milk fatty acid composition indicated a decreased ability to adapt to heat stress in O mares, which could have further affected the metabolic development of their foals. In conclusion, maternal obesity affected the fatty acid composition of milk, thus also influencing the foal’s plasma fatty acid composition and likely participating in the developmental programming observed in growing foals.

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Section: Introductionmentioning

confidence: 99%

Obesity during Pregnancy in the Horse: Effect on Term Placental Structure and Gene Expression, as Well as Colostrum and Milk Fatty Acid Concentration

Robles,

Rousseau-Ralliard,

Dubois

et al. 2023

Veterinary Sciences

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Equine Review

McGovern

2022

UK-Vet Equine

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A Bibliometric Analysis of Thromboelastography in Veterinary Clinical Use

Eralp İnan

2024

Harran Üniversitesi Veteriner Fakültesi Dergisi

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The evaluation of coagulation with thromboelastography (TEG) were and are in high interest for the last two decades in veterinary medicine. The main cause is the ability to detect hypo-, normo- and hypercoagulative states in a single TEG analysis. In clinical veterinary medicine, the importance of coagulation in terms of course and outcome in many diseases had been realized through researches over time. TEG studies had gained importance as traditional coagulation tests were inadequate, especially in cases complicated with hypercoagulation. The bibliometric analysis determined topics, researchers and countries of studies in veterinary clinical use of TEG. According tı the Web of Science (WoS) database, a total of 371 documents in this research field were identified between 1998 and 2023 (September). In 2012, with 39 articles, the highest number of studies were published. The most relevant author was Kristensen A.T. with 39 articles. In the list of corresponding authors’ countries, the first country with 189 authors was determined as the USA. Trend topics and their distribution over time had shown that dogs were the most studied animal species in clinical TEG use. A high number of studies on the topic hypercoagulability and immune-mediated hemolytic anemia was detected, but in the last 3 years new topics like antithrombotics and rational use were involved. The bibliometric analysis carried out has shown the changes over time in this field and the currentness of the subject, which were all important aspects in planning new studies. The results of the present study could be used in planning future studies in the field of veterinary clinical use of TEG.

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Thromboelastography in obese horses with insulin dysregulation compared to healthy controls

Cited by 4 publications

References 46 publications

Obesity during Pregnancy in the Horse: Effect on Term Placental Structure and Gene Expression, as Well as Colostrum and Milk Fatty Acid Concentration

Obesity during Pregnancy in the Horse: Effect on Term Placental Structure and Gene Expression, as Well as Colostrum and Milk Fatty Acid Concentration

Equine Review

A Bibliometric Analysis of Thromboelastography in Veterinary Clinical Use

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