Thrombolysis as Initial Treatment of Peripheral Native Artery and Bypass Graft Occlusions in a General Community Hospital

Thrombolysis for acute arterial occlusion

“…15 Other factors that are correlated with poor outcome are diabetes and continued tobacco use. 16,17 Clinical aspects that increase the likelihood of success are (1) guidewire traversal of the occluded graft, (2) presence of a graft that has been in place for Ͼ1 year, and (3) cases where an underlying lesion can be identified after lysis and treated successfully. 16 Complications.…”

Outcome of Thrombolysis and Thrombectomy for Thrombosed Endografts Inserted in the Superficial Femoral Artery for Occlusive Disease

“…Several studies found confounding factors that influence the success rate of thrombolysis, such as diabetes, a history of lower limb ischemia, an occluded bypass graft, and poor runoff. [10][11][12][13] In our study, the vast majority of patients were treated with thrombolysis. We could not identify a difference in outcome between patients treated with thrombolysis and those with thrombectomy, but again, sample size was a significant limitation.…”

Dutch Randomized Trial Comparing Standard Catheter-Directed Thrombolysis and Ultrasound-Accelerated Thrombolysis for Arterial Thromboembolic Infrainguinal Disease (DUET)

“…The added value of UST is expected in the more organized thrombi. Moreover, the literature has shown that the duration of ischemic symptoms does not significantly influence final outcome of thrombolysis, [2][3][4] and some patients present after 7 days because of mild ischemic symptoms. 27 This clinical study reflected common practice.…”

“…1 Moreover, several studies have shown that catheter-directed thrombolysis is a valuable treatment option for subacute occlusions as well. [2][3][4] Benefits of thrombolysis over surgical embolectomy are its minimally invasive character, more complete lysis of small side branches and outflow arteries, 5 and the possibility to identify and treat underlying lesions using percutaneous transluminal angioplasty (PTA) and stenting. A major limitation to this treatment is the occurrence of bleeding complications.…”