Background: There is no published risk score model to predict mortality and morbidity following Percutaneous Coronary Intervention in Saudi Arabia. We aim to identify risk predictors that can estimates risks associated with percutaneous coronary intervention (PCI) specific to Saudi population that can be incorporated in creation of a population specific risk model. Methods: Data of 418 patients who were treated with percutaneous coronary intervention at king faisal cardiac center (KFCC) were retrospectively collected from January 2015 till December 2017. Demographics and clinical data were measured to define clinical predictors associated with in hospital death and Major Adverse Cardiac Events (MACE). Results: The study included 418 patients who underwent PCI between January 2015 until December 2017. The majority of the patients were of Saudi nationality (92.4%). The mean age was 60.58 (±7.8). Out of the study subjects, 225 (53.8%) were 60 years of age and above. Majority were male 315 (75.36%). The most prevalent pre-procedural risk factors were hypertension in 82%, Diabetes Mellitus in 74.52%, and dyslipidaemia in 70.7% of patients. Non-ST-elevation myocardial infarction was the major presentation with a percentage of 58.39%. The PCI status among the patients was divided into 38.35% urgent PCI, 35.19% elective PCI, and 26.46% primary PCI. In-hospital mortality occurred in a total of 5 patients (1.2%). Nineteen patients (4.5 %) experienced post-procedural complications. Intra procedural cardiac arrest occurred in 5 patients (1.2%). four patients (0.96%) required blood transfusion three of them due to post procedure bleeding. Other procedure related complications were as follows, cardiac tamponade (0.49%), stroke (0.73%), contrast allergy (0.24%), contrast nephropathy (0.73%), new requirement for dialysis (0.49%), and death in Cath lab (0.24%). Dyslipidaemia, previous renal disease, PCI indication, cardiogenic shock, pre and post-procedural haemoglobin level as well as post-procedural creatinine level showed significate relationship with in hospital MACE. Conclusion: Our findings suggest favourable outcomes of patients treated with PCI, matching the international data. We have identified certain risk predictors that need to be confirmed by large scale and prospective data In order to generate a population specific risk score model.