Thrombolysis in the Age of Primary Percutaneous Coronary Intervention : Mini-Review and Meta-Analysis of Early PCI

Shammeri, Owayed Al; Garcia, LA

doi:10.12816/0006026

Cited by 8 publications

(7 citation statements)

References 25 publications

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“…The timely opening of the culprit vessels and restoration of the blood perfusion of ischemic myocardium is the main treatment for acute myocardial infarction (AMI). It helps in maintaining heart function and improves clinical prognosis ( 1 ). However, reperfusion injury caused by percutaneous trans-luminal coronary angioplasty and percutaneous coronary intervention (PCI) results in poor blood flow as well as stent restenosis ( 2 – 4 ).…”

Section: Introductionmentioning

confidence: 99%

Effects of remote ischemic post-conditioning on platelet activation of AMI patients

et al. 2018

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The recovery of ischemic myocardium blood perfusion is the main treatment option for acute myocardial infarction (AMI). However, this treatment option has multiple side effects that directly affect the quality of life of the patients. The activation of platelet function plays an important role in the occurrence, development and treatment of AMI. The aim of the present study was to analyze the effects of remote ischemic post-conditioning on platelet activation of AMI patients with primary PCI treatment and clinical prognosis. A total of 71 patients with AMI were treated with primary percutaneous coronary intervention (PCI). They were randomly divided into control group (n=34) and observation group (n=37). The patients in the observation group were treated with remote ischemic post-conditioning. Further, flow cytometer was used to detect the platelet alpha granule membrane glycoprotein (CD62P) and the percentages of activated IIb/IIIa (PAC-1). The maximum platelet aggregation rate induced by adenosine diphosphate (ADP) and arachidonic acid (AA) was measured by light transmittance aggrometer. The incidence of major adverse cardiac events (MACE) was compared between the two groups during the follow-up period of 6 months. The percentage of CD62P (24 h after PCI) in the observation group was significantly lower than control group (P<0.05). Further, the incidence of MACE in the observation group was also lower than that of the control group (P<0.05). Remote ischemic post-conditioning could reduce the incidence of MACE in patients with AMI after primary PCI treatment. Moreover, the above observation may be related to the improvement of platelet CD62P activation.

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Section: Introductionmentioning

confidence: 99%

Effects of remote ischemic post-conditioning on platelet activation of AMI patients

et al. 2018

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“…Thus, if patients cannot undergo PCI in a timely manner (within 2 h of acute MI), thrombolysis may be performed instead (O'gara et al, 2013 ). Following successful revascularization via thrombolysis, transfer to a PCI-capable facility and subsequent catheterization within 24 h of acute MI may further improve revascularization and patient outcome (Al Shammeri and Garcia, 2013 ; O'gara et al, 2013 ). Several clinical trials have also focused on comparing PCI to CABG.…”

Section: Strategies For Cardiac Repairmentioning

confidence: 99%

Cardiac Regeneration: New Insights Into the Frontier of Ischemic Heart Failure Therapy

Riching

Song

2021

Front. Bioeng. Biotechnol.

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Ischemic heart disease is the leading cause of morbidity and mortality in the world. While pharmacological and surgical interventions developed in the late twentieth century drastically improved patient outcomes, mortality rates over the last two decades have begun to plateau. Following ischemic injury, pathological remodeling leads to cardiomyocyte loss and fibrosis leading to impaired heart function. Cardiomyocyte turnover rate in the adult heart is limited, and no clinical therapies currently exist to regenerate cardiomyocytes lost following ischemic injury. In this review, we summarize the progress of therapeutic strategies including revascularization and cell-based interventions to regenerate the heart: transiently inducing cardiomyocyte proliferation and direct reprogramming of fibroblasts into cardiomyocytes. Moreover, we highlight recent mechanistic insights governing these strategies to promote heart regeneration and identify current challenges in translating these approaches to human patients.

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“…Notably, angioplasty is the most common percutaneous coronary intervention (PCI) method for CVD treatment [37,38] , and diagnostic angiography and PCI routinely utilize iodinated CM for vascular visualization [39,40] . Although angiograms and PCI can effectively diagnose and treat CVD patients, this can potentially lead to acute kidney diseases such as CIN induced by CM [41][42][43][44][45][46] . CM can be retained by the kidney where they have the potential to cause toxicity, resulting in acute renal injury [47] .…”

Section: Cin Pathophysiology In the Context Of Cvdmentioning

confidence: 99%

Oxidative stress and inflammation in the development of cardiovascular disease and contrast induced nephropathy

Cervantes-Gracia

Raja²,

Llanas-Cornejo

et al. 2020

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Utilization of contrast media to visualize vasculature structures in the setting of cardiovascular disorders (CVD) can lead to acute kidney injury, referred to as contrast-induced nephropathy (CIN). CIN can potentiate mortality and hospitalization in aged individuals, patients with CVD, nephropathy, enhancing kidney damage, and cardiac events. Preventing CIN by identifying risk factors is important. The underlying mechanisms of CIN pathology are unclear, but the key factors include direct cytotoxicity, oxidative stress, vascular and endothelial dysfunction and inflammatory processes. Reactive Oxygen Species and inflammatory mediators have been proposed as key factors influencing the development of CIN and CVD, and the elucidation of the interplay between the mechanisms evoked by them may provide a better understanding of the signaling processes happening in these conditions, thereby potentially enabling early identification, prevention and characterization of novel drug targets.

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Thrombolysis in the Age of Primary Percutaneous Coronary Intervention : Mini-Review and Meta-Analysis of Early PCI

Cited by 8 publications

References 25 publications

Effects of remote ischemic post-conditioning on platelet activation of AMI patients

Effects of remote ischemic post-conditioning on platelet activation of AMI patients

Cardiac Regeneration: New Insights Into the Frontier of Ischemic Heart Failure Therapy

Oxidative stress and inflammation in the development of cardiovascular disease and contrast induced nephropathy

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