Thrombolytic agents for arterial and venous thromboses in neonates

Abstract

No conclusions could be made as no eligible studies were found. It is time that a randomised controlled trial was performed comparing thrombolytic therapy to heparin therapy to aid neonatologists in the treatment of arterial and venous thromboses.

Outcomes following neonatal portal vein thrombosis: A descriptive, single‐center study and review of anticoagulant therapy

“…The approach to the management of PVT in neonates is not standardized because of the absence of solid evidence with regard to the safety and efficacy of antithrombotic therapy and current reports of favorable outcomes based on conservative management. Therefore, a majority of healthcare providers err on the side of caution and assume a watch‐and‐wait approach because treatment needs to be judiciously weighed in terms of benefit versus risk of causing harm.…”

Neonatal pulmonary artery thrombosis

“…[3] A recent systematic review provided no conclusions about the most appropriate treatment, as no eligible studies were found. [7] Thrombolytic therapy seems to be the most preferred treatment option particularly in the case of hemodynamically compromising pulmonary embolism. [8] Another option is transcatheter thrombectomy.…”

Single versus bihemispheric amplitude‐integrated electroencephalography in relation to cerebral injury and outcome in the term encephalopathic infant

“…Subtle seizures are often the only finding in otherwise healthy neonates with neonatal cerebral infarction which has been under‐recognised in the neonatal period 18 . The reported incidence of cerebral infarction in the newborn is increasing with the availability of more sensitive neuroimaging 19,20 allowing for therapeutic options such as thrombolysis 21,22 and constraint therapies 23 following diagnosis. However, all neuroprotective or rehabilitation interventions require early recognition.…”