Thrombophilia and Recurrent Pregnancy Loss : Is Heparin Still the Drug of Choice ? = أهبة التخثر و فقدان الحمل المتكرر : هل الهيبارين لايزال العلاج المفضل ؟

Abu-Heija, Adel T.

doi:10.12816/0003333

Cited by 20 publications

(12 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It is realized by the researchers that one of the causative agents of recurrent abortion during pregnancy could be the increased amount of blood clotting (thrombophilia) in the venous of these patients (27,28). As an indicator of blood clots, this study determined the amount of lupus anticoagulant antibody in the blood of pregnant women.…”

Section: Discussionmentioning

confidence: 99%

Association between TORCH infection and lupus anticoagulant antibody in pregnant women with recurrent abortion

Hiwa R. Fatah

2023

Cell Mol Biol (Noisy-le-grand)

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Association between TORCH infection and lupus anticoagulant antibody in pregnant women with recurrent abortion

Hiwa R. Fatah

2023

Cell Mol Biol (Noisy-le-grand)

View full text Add to dashboard Cite

“…In recent years, NGS methods, particularly thrombophilia is a common risk factor for RPL and can be observed in about 40% to 50% of RPL cases [23]. Inherited variants in some thrombophilic factors have been extensively investigated for their associations with RPL, including factor V (FV), prothrombin, and homocysteine metabolism-associated enzymes, namely methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTR), and methionine synthase reductase (MTRR) [24].…”

Section: Single Nucleotide Variantsmentioning

confidence: 99%

Immunologic Factors and Genomic Considerations in Recurrent Pregnancy Loss: A Review

Montazeri,

Tajamolian,

Hosseini

et al. 2024

IJML

View full text Add to dashboard Cite

Recurrent pregnancy loss (RPL), which is also known as repeated miscarriage, affects around 2-3% of women who are trying to conceive. While some factors contributing to RPL have been identified, the cause of almost half of all cases remains unknown. Immunological factors have been proposed as one of the potential causes of such miscarriages. However, it is hard to track the common factors leading to RPL since the individual genomic identity of aborted fetuses is different in a family like other siblings. The immunological factors involved in the pathogenesis of miscarriage generally result from either the function of the maternal immune system attributable to her genomic background or the fetal origination established by both maternal and paternal genomic backgrounds that constitute the fetal genome.

show abstract

“…A series of studies suggest that thrombophilia might increase women’s risk for RPL by impairing normal placental vascular function. It is important to note that thrombosis or occlusion of placental vessels may decrease placental perfusion, which may contribute to adverse pregnancy outcomes including RPL [ 78 ]. Notably, several inherited variants in three thrombophilic factors, such as factor V gene, homocysteine metabolism associated enzymes ( MTHFR , MTR and MTRR ), and prothrombin gene ( PTG ), have been extensively investigated for their associations with RPL [ 79 , 80 ].…”

Section: Maternal and Paternal Genetic Factors Account For Rplmentioning

confidence: 99%

“…Several recent studies have also found that paternal C677T polymorphism is connected with RPL aetiology [ 93 , 169 ]. It is now widely accepted that thrombophilia is a common risk factor for RPL and can be observed in about 40%–50% of RPL cases [ 78 ]. Ozdemir et al.…”

Section: Maternal and Paternal Genetic Factors Account For Rplmentioning

confidence: 99%

Understanding recurrent pregnancy loss: recent advances on its etiology, clinical diagnosis, and management

et al. 2022

View full text Add to dashboard Cite

Recurrent pregnancy loss (RPL) has become an important reproductive health issue worldwide. RPL affects about 2%–3% of reproductive-aged women, and makes serious threats to women’s physical and mental health. However, the etiology of approximately 50% of RPL cases remains unknown (unexplained RPL), which poses a big challenge for clinical management of these patients. RPL has been widely regarded as a complex disease where its etiology has been attributed to numerous factors. Heretofore, various risk factors for RPL have been identified, such as maternal ages, genetic factors, anatomical structural abnormalities, endocrine dysfunction, prethrombotic state, immunological factors, and infection. More importantly, development and applications of next generation sequencing technology have significantly expanded opportunities to discover chromosomal aberrations and single gene variants responsible for RPL, which provides new insight into its pathogenic mechanisms. Furthermore, based upon patients’ diagnostic evaluation and etiologic diagnosis, specific therapeutic recommendations have been established. This review will highlight current understanding and recent advances on RPL, with a special focus on the immunological and genetic etiologies, clinical diagnosis and therapeutic management.

show abstract

Thrombophilia and Recurrent Pregnancy Loss : Is Heparin Still the Drug of Choice ? = أهبة التخثر و فقدان الحمل المتكرر : هل الهيبارين لايزال العلاج المفضل ؟

Cited by 20 publications

References 59 publications

Association between TORCH infection and lupus anticoagulant antibody in pregnant women with recurrent abortion

Association between TORCH infection and lupus anticoagulant antibody in pregnant women with recurrent abortion

Immunologic Factors and Genomic Considerations in Recurrent Pregnancy Loss: A Review

Understanding recurrent pregnancy loss: recent advances on its etiology, clinical diagnosis, and management

Contact Info

Product

Resources

About