Thrombophilia and venous thromboembolism in pregnancy: a meta-analysis of genetic risk

The Role of APC-Resistance for Predicting Venous Thrombosis and Pregnancy Complications in Carriers of Factor V Leiden (1691) G/A Mutation

“…Summarizing the data presented above, we can note the following patterns: The obtained data are consistent with the results of previously published meta-analyses and clinical recommendations [17][18][19]21]. Nevertheless, despite an associative, statistically significant relation between FVL 1691 GA and the risk of VTEC development and pregnancy complications, up to now there are no international recommendations for the prevention of pregnancy complications in FVL 1691 GA patients.…”

“…However, the clinical manifestations of factor V Leiden are heterogeneous and can be not only in the form of thromboembolic events but also determine the risk of developing gestational complications, including the great obstetrical syndrome [15][16][17]. Modern ideas about the relation between FVL 1691 GA carriage and the risk of developing gestational complications are highly contradictory, the available studies in this direction are inadequate and ethnically heterogeneous and often contradict with each other [18][19][20][21]. According to the conclusions of world experts, it is impossible to make a final decision on the cause-effect relation between the FVL 1691 GA carriage and the unfavorable course of pregnancy.…”

<p>Inherited Thrombophilia in a Lebanese Family of Four Generations: A Case Report of Recurrent Miscarriage</p>

“…A meta-analysis showed an increased risk of VTE in pregnancy with FVL and FII G20210A carrier state. 6 Consequently, women with unexplained early RPL should be targeted for FVL and FII G20210A testing, which are considered the most frequently requested genetic thrombophilia investigations. 6 However, most experts and evidence-based guidelines argue against such measurements due to a lack of benefits.…”

“…6 Consequently, women with unexplained early RPL should be targeted for FVL and FII G20210A testing, which are considered the most frequently requested genetic thrombophilia investigations. 6 However, most experts and evidence-based guidelines argue against such measurements due to a lack of benefits. 2 Furthermore, the risk of thrombosis increased significantly in prothrombin G20210A and FV G1691A mutation carriers using combined hormonal contraceptives (CHCs).…”

Epidemiologie, Risikofaktoren und Risikostratifizierung venöser Thromboembolien (VTE) in Schwangerschaft und Wochenbett

“…Grades) abhängt, wird derzeit kontrovers diskutiert. Entgegen den Ergebnissen aus Familien-assozi- Interessant ist eine jüngste Metaanalyse aus 12 Gen-assoziierten (Genotyp und Phänotyp) case-control Studien [53], die unter Berücksichtigung des Erbganges keine signifikanten Unterschiede hinsichtlich des genetischen Risikos für VTE in der Schwangerschaft zwischen homozygoter und heterozygoter Faktor V-Leiden-Mutation (OR 7,28; 95 % KI 5,3-9,6) nachweisen konnte. MTHFR-Mutationen waren ohne Einfluss auf das VTE-Risiko in der Schwangerschaft.…”