Thrombophilic Disorders in Migraine

Cavestro, Cinzia; Mandrino, Silvia

doi:10.3389/fneur.2014.00120

Cited by 6 publications

(4 citation statements)

References 31 publications

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“…In the current study, there was no statistically significant difference in mean serum level of protein C between migraine patients and healthy controls, which agreed with previous studies done by Bassi et al [11], Rajan et al [12], D' Amico et al [9], Cavestro and Mandrino [13] who reported that unlike protein S deficiency which has a high prevalence, the main problem of studying protein C deficiency is its very low prevalence in the general population (0.14-0.40%). This usually requires larger sample sizes to detect any significant difference in prevalence between migraine patients and control group.…”

Section: Discussionsupporting

confidence: 93%

Association between blood coagulability and migraine

Fahmy

Hamdy

Mahmoud

et al. 2022

Egypt J Neurol Psychiatry Neurosurg

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Background An association between migraine and stroke has been suggested for a long period, although conclusive evidence has not been reported. Several theories about hypercoagulability have been proposed for the association of ischemic stroke and migraine especially migraine with aura. This study aimed to assess blood coagulability in patients with migraine. Results Mean serum levels of protein S and anti-thrombin III were significantly lower in migraine patients compared to control subjects. Migraine patients showed abnormal MRI findings in the form of white matter hyper-intense lesions and ischemic foci compared to healthy controls. A significant negative correlation was detected between serum protein C level and intensity of migraine headache. Also, a significant correlation was found between deficient serum protein S and abnormal findings in brain MRI. Serum protein C deficiency is an independent predictor for migraine intensity grade. Conclusions There is an association between migraine and hypercoagulability, which may indicate increased risk of cerebral ischemic events in migraine patients and suggest adding prophylactic therapy to the management strategies of such patients.

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Section: Discussionsupporting

confidence: 93%

Association between blood coagulability and migraine

Fahmy

Hamdy

Mahmoud

et al. 2022

Egypt J Neurol Psychiatry Neurosurg

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“…The aforementioned association appears to be stronger for MA sufferers compared to MO patients, 17 fuelling the theory that CSD may be a sequel to systematic hypoperfusion disorders 18 . Potential mechanisms that link migraine to vascular diseases include endovascular dysfunction, vasospasm, and additional altered functional vascular properties, 19,20 hypercoagulable states and thrombophilic diathesis, 21,22 as well as the microembolic induction of CSD (increased incidence of atrial fibrillation and patent foramen ovale in migraine patients) 23,24 …”

Section: Introductionmentioning

confidence: 99%

Serum Homocysteine, Pyridoxine, Folate, and Vitamin B12 Levels in Migraine: Systematic Review and Meta‐Analysis

et al. 2020

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Background Migraine, especially migraine with aura (MA), has been linked to increased risk for ischemic cerebrovascular disease. The possible role of elevated serum homocysteine (Hcy, a cause of thrombophilia) in migraine has been demonstrated by several studies. Objective The present study aims to review and meta‐analyze data from studies investigating the difference of serum Hcy and Hcy lowering vitamins between migraine patients and healthy controls (HC), as well as between patients with MA and migraine without aura (MO). Methods Literature search involved MEDLINE, Embase, CENTRAL, Google Scholar, and trial registries. The Newcastle‐Ottawa Scale was used to evaluate the quality of the retrieved studies. Standardized mean differences (SMDs) and 95% confidence intervals (95%CIs) were calculated. Funnel‐plots were utilized for the evaluation of publication bias. Results Overall, 29 (28 case‐control and 1 cross‐sectional) studies were retrieved. Meta‐analysis was indicative of higher Hcy concentration in migraine patients vs HC overall [adults and children: 16 studies, I2 = 81%, SMD = 0.41, 95%CI = (0.20, 0.61)]. Hcy was consistently elevated in adults with migraine [adults: 12 studies, I2 = 76%, SMD = 0.35, 95%CI = (0.15, 0.54); children: 1 study, SMD = 0.37, 95%CI = (−0.05, 0.79)]. Subgroup analyses reproduced the results for both adults with MA [7 studies, I2 = 83%, SMD = 0.37, 95%CI = (0.03, 0.71)] and MO [5 studies, I2 = 84%, SMD = 0.46, 95%CI = (0.03, 0.89)]. Figures for serum folate were lower in the overall comparison of migraine patients with HC [adults and children: 11 studies, I2 = 87%, SMD = −0.36, 95%CI = (−0.68, −0.05); adults: 8 studies, I2 = 6%, SMD = −0.11, 95%CI = (−0.22, 0.01); children: 1 study, SMD = −0.71, 95%CI = (−1.14, −0.29); MA adults: 4 studies, I2 = 44%, SMD = −0.16, 95%CI = (−0.35, 0.04); MO adults: 4 studies, I2 = 47%, SMD = −0.17, 95%CI = (−0.44, 0.10)]. Serum vitamin B12 levels were not different between migraine patients and HC [adults and children: 11 studies, I2 = 88%, SMD = −0.24, 95%CI = (−0.57, 0.09); adults: 8 studies, I2 = 57%, SMD = −0.10, 95%CI = (−0.28, 0.08); children: 1 study, SMD = 0.29, 95%CI = (−0.13, 0.71); MA adults: 4 studies, I2 = 63%, SMD = −0.14, 95%CI = (−0.48, 0.20); MO adults: 4 studies, I2 = 59%, SMD = −0.15, 95%CI = (−0.45, 0.15)]. Serum Hcy was lower in MO than MA [adults and children: 10 studies, I2 = 39%, SMD = 0.30, 95%CI = (0.14, 0.46), adults: 6 studies, I2 = 29%, SMD = 0.21, 95%CI = (0.09, 0.36), children: 1 study, SMD = 0.51, 95%CI = (0.22, 0.80)]. Serum folate and vitamin B12 did not differ between MA and MO. Conclusions Our results suggest that there is a possible link between migraine, mainly MA, and elevated serum Hcy.

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“…Other than these, network analyses revealed vesicular transport, membrane trafficking, coagulation or hemostasis, and the regulation of apoptosis as the most significant pathways ( Figure 1 , Table 3 ). Some of these pathways make sense in light of previous studies; for example, thrombophilic conditions were previously described in patients with migraine [ 50 , 51 ] and acute unilateral vestibular paresis [ 52 ]. Additionally, in an exome sequencing study of early onset Meniere’s disease patients, network analysis revealed the genes involved in cell death, with the apoptosis of hair cells being suggested as a potential pathologic mechanism [ 53 ].…”

Section: Discussionmentioning

confidence: 99%

Rare Coding Variants in Patients with Non-Syndromic Vestibular Dysfunction

Sumalde

Scholes

Kalmanson

et al. 2023

Genes

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Vertigo due to vestibular dysfunction is rare in children. The elucidation of its etiology will improve clinical management and the quality of life of patients. Genes for vestibular dysfunction were previously identified in patients with both hearing loss and vertigo. This study aimed to identify rare, coding variants in children with peripheral vertigo but no hearing loss, and in patients with potentially overlapping phenotypes, namely, Meniere’s disease or idiopathic scoliosis. Rare variants were selected from the exome sequence data of 5 American children with vertigo, 226 Spanish patients with Meniere’s disease, and 38 European–American probands with scoliosis. In children with vertigo, 17 variants were found in 15 genes involved in migraine, musculoskeletal phenotypes, and vestibular development. Three genes, OTOP1, HMX3, and LAMA2, have knockout mouse models for vestibular dysfunction. Moreover, HMX3 and LAMA2 were expressed in human vestibular tissues. Rare variants within ECM1, OTOP1, and OTOP2 were each identified in three adult patients with Meniere’s disease. Additionally, an OTOP1 variant was identified in 11 adolescents with lateral semicircular canal asymmetry, 10 of whom have scoliosis. We hypothesize that peripheral vestibular dysfunction in children may be due to multiple rare variants within genes that are involved in the inner ear structure, migraine, and musculoskeletal disease.

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Thrombophilic Disorders in Migraine

Cited by 6 publications

References 31 publications

Association between blood coagulability and migraine

Association between blood coagulability and migraine

Serum Homocysteine, Pyridoxine, Folate, and Vitamin B12 Levels in Migraine: Systematic Review and Meta‐Analysis

Rare Coding Variants in Patients with Non-Syndromic Vestibular Dysfunction

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