Thrombophlebitis Migrans and Visceral Carcinoma

Platelet-derived thrombospondin-1 is a critical negative regulator and potential biomarker of angiogenesis

“…4 Elevated platelet counts are often associated with poor survival in a variety of cancers, including glioblastomas, gastric, colorectal cancers, and gynecologic malignancies. There is a strong body of evidence indicating a role for platelets in cancer metastasis, and treatments involving platelet-reducing agents have been beneficial in reducing the number of metastatic lesions in several mouse models.…”

“…4,5 Although platelets circulate throughout the body and participate in the control of hemostasis, increased platelet counts and activation of the coagulation cascade are often seen in cancer patients. 6,7 In addition, several studies indicate a role for platelets in promoting metastatic disease.…”

Thrombotic syndrome after vaccination in a subject with occult carcinoma of the bronchus

“…A case of basophil (mastcell) leukaemia in a cat, the fifth so far reported, is I wish to thank Dr A. C. Hunt for his advice and encouragement. (Sproul, 1938;Kenney, 1943;Edwards, 1949;Durham, 1955;Lieberman et al, 1961), is fairly infrequent and its origins are obscure. Consequently, we feel it useful to report an unusual case of severe thrombotic syndrome that developed under exceptional circumstances in a patient with pulmonary carcinoma.…”

Host‐tumor Antagonism. Xxx. Some Systemic Manifestations of Cancer*

“…Durham (5) believes that the presence of thrombophlebitis, particularly in a patient over 35 years of age, warrants a presumptive diagnosis of visceral carcinoma until disproved. Not infrequently, when the vascular disorder is observed, there are no other signs or symptoms to suggest carcinoma.…”