Thromboplastin Generation Accelerator, a Newly Recognized Component of the Blood Coagulation Mechanism Present in Excess in Certain Thrombotic States*

Pascuzzi, Chris A.; Spittel, John A.; Thompson, John H.; Owen, Charles A.

doi:10.1172/jci104325

Cited by 24 publications

(2 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Spittell et al (1960) observed accelerated formation of thromboplastin in 22 out of 69 patients with occlusive arterial and venous disease, and this phenomenon could be temporary or prolonged. Pascuzzi et al (1961) and Spittell et al (1961) postula*ed the presence of a thromboplastin generation accelerator from their observations on the effects of artificially retarding the accelerated plasma thromboplastin generation time in such patients. Dehydration may be a factor in the occurrence of venous thrombosis, but the cause for occlusive arterial disease is more complex.…”

Section: Discussionmentioning

confidence: 99%

Vascular Complications in Nephrotic Syndrome: Relationship to Steroid Therapy and Accelerated Thromboplastin Generation

Mukherjee¹,

Toh²,

Chan³

et al. 1970

BMJ

View full text Add to dashboard Cite

Summary: Arterial thrombosis and renal vein thrombosis occurred in two men and one woman, respectively, treated with steroids for the nephrotic syndrome. Raised serum cholesterol occurred in one patient only. Though bleeding, clotting, and prothrombin times, as well as the platelet counts, were normal, the rate of thromboplastin generation was increased in all three patients. Adding heparin to the plasma of one patient slowed the rate, and suggested that the raised rate could be due to removal or suppression of such normal circulating coagulation inhibitors. The thromboplastin generation test seems to be useful in diagnosing and managing such hypercoagulable states, and may help in further investigations of their causes.

show abstract

Section: Discussionmentioning

confidence: 99%

Vascular Complications in Nephrotic Syndrome: Relationship to Steroid Therapy and Accelerated Thromboplastin Generation

Mukherjee¹,

Toh²,

Chan³

et al. 1970

BMJ

View full text Add to dashboard Cite

show abstract

“…The phenomenon seemed to be caused by a protein which is present in normal persons, but is markedly increased in patients with thrombotic tendencies. Pascuzzi, et al (20) found the accelerating principle to be different from all known clotting factors and called it "thromboplastin generation accelerator." In malignancies and in postoperative states the evidence by means of a "retarded" thromboplastin generation test pointed indirectly to an increase in a factor indistinguishable from antihemophilic globulin.…”

Section: Discussionmentioning

confidence: 99%

Hypercoagulability Syndrome Due to Heparin Co-Factor Deficiency

Bj¹,

Vahabzadeh²

1964

Thromb Haemost

View full text Add to dashboard Cite

SummaryA case of hypercoagulability syndrome in a 35 years old male is reported. An abnormal heparin resistance was found which could be defined by means of a heparin clot-inhibition test as a deficiency in heparin co-factor. The required anticoagulant doses of heparin were forty times as high as in cases with intact heparin co-factor. The factor seemed to be used up in the process of coagulation, as plasma, but not serum, was able to correct the deficiency in vitro. Plasma infusions were helpful for four days, but a complete recovery was achieved only after an intensive course of fever therapy.The phenomenon of blood clotting should be regarded as a dynamic process which is facilitated by an array of clot promoting factors and opposed by a system of natural anticoagulants.

show abstract

Christmas Disease and Myocardial Infarction

Brody¹

1965

Arch Intern Med

View full text Add to dashboard Cite

Initial plasma replacement, because of the patient's age and indolence of the bleeding, was cautious so that 10 ml/kg plasma (700 ml) was given over the first 36 hours without clinical improvement. The transfusion rate was increased and 1,000 ml plasma was administered during the following day. Bleeding thereafter lessened appreciably and only 250 ml plasma was given on the third day. On the evening of the

show abstract

Thromboplastin Generation Accelerator, a Newly Recognized Component of the Blood Coagulation Mechanism Present in Excess in Certain Thrombotic States*

Cited by 24 publications

References 16 publications

Vascular Complications in Nephrotic Syndrome: Relationship to Steroid Therapy and Accelerated Thromboplastin Generation

Vascular Complications in Nephrotic Syndrome: Relationship to Steroid Therapy and Accelerated Thromboplastin Generation

Hypercoagulability Syndrome Due to Heparin Co-Factor Deficiency

Christmas Disease and Myocardial Infarction

Contact Info

Product

Resources

About