2022
DOI: 10.1002/ams2.769
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Thrombopoietin and collagen in low doses cooperatively induce human platelet activation

Abstract: Aim In acute medicine, we occasionally treat life‐threatening conditions such as sepsis and trauma, which cause severe thrombocytopenia. Serum thrombopoietin levels have been reported to increase under the condition of thrombocytopenia related to severity. Collagen is a crucial activator of platelets, and Rho family members, such as Rho/Rho‐kinase and Rac, play roles as active molecules involved in the intracellular signaling pathways in platelet activation. The present study aimed to elucidate th… Show more

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Cited by 3 publications
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