Thrombopoietin as Early Biomarker of Disease Severity in Patients With Acute Pancreatitis

Lupia, Enrico; Pigozzi, Luca; Pivetta, Emanuele; Bosco, Ornella; Vizio, Barbara; Loiacono, Maria; Lucchiari, Manuela; Battista, Stefania; Morello, Fulvio; Moiraghi, Corrado; Mengozzi, Giulio; Montrucchio, Giuseppe

doi:10.1097/mpa.0000000000000752

Cited by 6 publications

(4 citation statements)

References 46 publications

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“… 46 Interestingly, one of the mechanisms that may sustain increased THPO levels in inflammatory systemic diseases is represented by augmented hepatic synthesis stimulated by IL-6. 47 Furthermore, disease severity is a major determinant of elevated THPO levels in patients affected by sepsis 48 or acute pancreatitis, 49 suggesting that THPO may be proposed as a potential prognostic marker in these pathologic conditions.…”

Section: Introductionmentioning

confidence: 99%

Thrombopoietin participates in platelet activation in COVID-19 patients

Lupia¹,

Capuano²,

Vizio³

et al. 2022

eBioMedicine

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Section: Introductionmentioning

confidence: 99%

Thrombopoietin participates in platelet activation in COVID-19 patients

Lupia¹,

Capuano²,

Vizio³

et al. 2022

eBioMedicine

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“…AP patients develops severe AP (SAP) with a mortality rate approximately 30% [3]. SAP is characterized by multiple organ failure as well as necrosis of the pancreas and the surrounding tissues [4].…”

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confidence: 99%

“…Due to the facet of rapid deterioration and high mortality of SAP, early identification of disease severity becomes essential for the evaluation of clinical treatment and the management of SAP [5]. Many multi-factoring scoring systems such as acute physiology and chronic health evaluation II (APACHE II) score and Ranson score have been widely applied for assessing SAP severity and predicting prognosis in clinical practice [3,6]. However, under some circumstances such as at the time of initial presentation of SAP, the use of APACHE II score and Ranson score may be complex and with low sensitivity [3,7].…”

mentioning

confidence: 99%

“…Many multi-factoring scoring systems such as acute physiology and chronic health evaluation II (APACHE II) score and Ranson score have been widely applied for assessing SAP severity and predicting prognosis in clinical practice [3,6]. However, under some circumstances such as at the time of initial presentation of SAP, the use of APACHE II score and Ranson score may be complex and with low sensitivity [3,7]. Therefore, it is essential to explore novel sensitive biomarkers with the potential for assisting disease monitoring and improving prognosis in SAP patients.…”

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confidence: 99%

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The correlation of JKAP with risk, severity, inflammation and in-hospital mortality of severe acute pancreatitis

Min

Han

2019

Preprint

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Background This study aimed to investigate the predictive value of JNK pathway-associated phosphatase (JKAP) level for severe acute pancreatitis (SAP) risk, and its association with disease severity, inflammation and in-hospital mortality in SAP patients. Methods Our study recruited 50 SAP patients, 50 moderate-severe acute pancreatitis (MSAP) patients, 50 mild acute pancreatitis (MAP) patients and 50 healthy controls. And the serum samples were obtained from all acute pancreatitis patients within 24 hours after admission and from health controls at their enrollment to detect JKAP level by enzyme-linked immunosorbent assay. Results JKAP level was decreased in SAP patients compared with healthy controls, MSAP and MAP patients. And receiver operating characteristics (ROC) curve analysis revealed that JKAP could not only distinguish SAP patients from healthy controls (AUC: 0.914, 95%CI: 0.857-0.971), but also differentiate SAP patients from MAP patients (AUC: 0.869, 95%CI: 0.802-0.937) and MSAP patients (AUC: 0.712, 95%CI: 0.610-0.813). In SAP patients, JKAP was negatively correlated with Ranson score, acute physiology and chronic health care evaluation II (APACEH II) score, sequential organ failure assessment (SOFA) score and C-reactive protein (CRP). And lower JKAP level, higher CRP level, Ranson score, APACEH II score and SOFA score were associated with increased in-hospital mortality in SAP patients. Additionally, ROC curve analysis showed that JKAP could predict decreased in-hospital mortality in SAP patients (AUC: 0.720, 95%CI: 0.526-0.914). Conclusions JKAP might serve as a biomarker for disease risk and management for SAP.

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Assessment of the course of acute pancreatitis in the light of aetiology: a systematic review and meta-analysis

Bálint

Für

Kiss

et al. 2020

Sci Rep

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The main causes of acute pancreatitis (AP) are biliary disease, alcohol consumption, hypertriglyceridaemia (HTG) and endoscopic retrograde cholangiopancreatography (ERCP). The aim of this meta-analysis was to evaluate the effects of these aetiological factors on the severity and outcome of AP. Pubmed and Embase were searched between 01/01/2012 and 31/05/2020. Included articles involved adult alcoholic, biliary, HTG- or post-ERCP AP (PAP) patients. Primary outcome was severity, secondary outcomes were organ failures, intensive care unit admission, recurrence rate, pancreatic necrosis, mortality, length of hospital stay, pseudocyst, fluid collection and systematic inflammatory response syndrome. Data were analysed from 127 eligible studies. The risk for non-mild (moderately severe and severe) condition was the highest in HTG-induced AP (HTG-AP) followed by alcoholic AP (AAP), biliary AP (BAP) and PAP. Recurrence rate was significantly lower among BAP vs. HTG-AP or AAP patients (OR = 2.69 and 2.98, 95% CI 1.55–4.65 and 2.22–4.01, respectively). Mortality rate was significantly greater in HTG-AP vs. AAP or BAP (OR = 1.72 and 1.50, 95% CI 1.04–2.84 and 0.96–2.35, respectively), pancreatic necrosis occurred more frequently in AAP than BAP patients (OR = 1.58, 95% CI 1.08–2.30). Overall, there is a potential association between aetiology and the development and course of AP. HTG-AP is associated with the highest number of complications. Furthermore, AAP is likely to be more severe than BAP or PAP. Greater emphasis should be placed on determining aetiology on admission.

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Thrombopoietin as Early Biomarker of Disease Severity in Patients With Acute Pancreatitis

Abstract: Our data provide the first evidence for TPO as potential early prognostic biomarker in AP patients. High TPO levels at hospital admission may predict organ dysfunction, sepsis, and fatal outcome in AP patients.

Cited by 6 publications

References 46 publications

Thrombopoietin participates in platelet activation in COVID-19 patients

Thrombopoietin participates in platelet activation in COVID-19 patients

The correlation of JKAP with risk, severity, inflammation and in-hospital mortality of severe acute pancreatitis

Assessment of the course of acute pancreatitis in the light of aetiology: a systematic review and meta-analysis

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