Thromboresistant semi-IPN hydrogel coating: Towards improvement of the hemocompatibility/biocompatibility of metallic stent implants

Obiweluozor, Francis O.; Tiwari, Arjun Prasad; Lee, Jun Hee; Tumurbaatar, Batgerel; Kim, Ju Yeon; Lee, Dohee; Park, Chan Hee; Kim, Cheol Sang

doi:10.1016/j.msec.2019.02.054

Cited by 30 publications

(10 citation statements)

References 75 publications

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“…SAED (Figure S2b, Supporting Information) and pXRD (Figure e) provided evidence for an amorphous‐to‐crystal transition, showing an increase in the reflections corresponding to both the (002) and (211) planes of HAP over time. The formation of HAP was further confirmed by the appearance of phosphate v 4 bending vibrations at 565 and 600 cm −1 at the expense of the broad band at 560 cm −1 (Figure S2c, Supporting Information) . The thermogravimetric and differential thermal analysis (TG/DTA) measurements (Figure f) revealed an endothermic peak between 20 and 200 °C and an exothermic peak between 200 and 400 °C, which are assigned to the loss of water and the decomposition of organics, respectively.…”

mentioning

confidence: 78%

Osteoporotic Bone Recovery by a Highly Bone‐Inductive Calcium Phosphate Polymer‐Induced Liquid‐Precursor

Yao

Lin

et al. 2019

Advanced Science

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Osteoporosis is an incurable chronic disease characterized by a lack of mineral mass in the bones. Here, the full recovery of osteoporotic bone is achieved by using a calcium phosphate polymer‐induced liquid‐precursor (CaP‐PILP). This free‐flowing CaP‐PILP material displays excellent bone inductivity and is able to readily penetrate into collagen fibrils and form intrafibrillar hydroxyapatite crystals oriented along the c‐axis. This ability is attributed to the microstructure of the material, which consists of homogeneously distributed ultrasmall (≈1 nm) amorphous calcium phosphate clusters. In vitro study shows the strong affinity of CaP‐PILP to osteoporotic bone, which can be uniformly distributed throughout the bone tissue to significantly increase the bone density. In vivo experiments show that the repaired bones exhibit satisfactory mechanical performance comparable with normal ones, following a promising treatment of osteoporosis by using CaP‐PILP. The discovery provides insight into the structure and property of biological nanocluster materials and their potential for hard tissue repair.

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mentioning

confidence: 78%

Osteoporotic Bone Recovery by a Highly Bone‐Inductive Calcium Phosphate Polymer‐Induced Liquid‐Precursor

Yao

Lin

et al. 2019

Advanced Science

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“…Additionally, according to the Centers for Disease Control and Prevention, 30,100 CLABSI cases are reported every year in the intensive care units and acute care facilities of the US . As such, the development of a thromboresistant and antimicrobial catheter-coating material is of utmost importance. − However, another consideration for the development of a catheter-coating material is to design a material that would form a “biocompatible system” when placed in the major vein. − The term biocompatible has been defined as “the ability of a material to perform with an appropriate host response in a specific situation” . To explain in simpler terms, this means that a material is considered biocompatible if it does not elicit any adverse reactions in the living system.…”

Section: Introductionmentioning

confidence: 99%

Multipronged Approach to Combat Catheter-Associated Infections and Thrombosis by Combining Nitric Oxide and a Polyzwitterion: a 7 Day In Vivo Study in a Rabbit Model

Singha

Goudie

Liu

et al. 2020

ACS Appl. Mater. Interfaces

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The development of nonfouling and antimicrobial materials has shown great promise for reducing thrombosis and infection associated with medical devices with aims of improving device safety and decreasing the frequency of antibiotic administration. Here, the design of an antimicrobial, anti-inflammatory, and antithrombotic vascular catheter is assessed in vivo over 7 d in a rabbit model. Antimicrobial and antithrombotic activity is achieved through the integration of a nitric oxide donor, while the nonfouling surface is achieved using a covalently bound phosphorylcholine-based polyzwitterionic copolymer topcoat. The effect of sterilization on the nonfouling nature and nitric oxide release is presented. The catheters reduced viability of Staphylococcus aureus in long-term studies (7 d in a CDC bioreactor) and inflammation in the 7 d rabbit model. Overall, this approach provides a robust method for decreasing thrombosis, inflammation, and infections associated with vascular catheters.

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“…Previous studies demonstrated that plasma exosomes helped improve ischemic stroke injury. [ 47,48 ] In this study, the use of DSPE to bridge exosomes could improve the biocompatibility and stability of exosomes compared with the direct encapsulation of exosomes with polymers, contributing to vascular remodeling. [ 4,17 ] This study represents a significant departure from previous work on ROS‐responsive exosome coatings, as exemplified by Hu et al.…”

Section: Discussionmentioning

confidence: 99%

Preparation of ROS‐Responsive Exosome Coating of Nitinol Material for Making the Neurointerventional Stent

Duan

et al. 2023

Adv Materials Inter

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Nitinol (NiTi) alloy is an ideal material for preparing neurointerventional stents due to its excellent mechanical properties and biocompatibility. However, NiTi stents without surface‐specific functionalization cause a high rate of stent thrombosis and in‐stent restenosis after implantation. In ischemic stroke, exosomes have a role in regulating nervous system development, regeneration, vascular remodeling, and neuroinflammation. In this work, the effect of exosome coating on the biocompatibility of NiTi alloy is evaluated. NiTi alloy is successively immersed in relevant solution (sodium alginate, 3‐aminophenylboronic acid, distearoylphosphatidylethanolamine, and exosomes) to form ROS‐responsive exosome coated surfaces. In vitro experiments (platelets, endothelial cells, smooth muscle cells, and macrophages) and in vivo subcutaneous implantation experiments are performed to test coatings for biocompatibility. The results show that the modified NiTi alloy surface has high hydrophilicity, which has the functions of inhibiting platelet aggregation, promoting endothelialization, inhibiting smooth muscle cell migration, anti‐inflammatory, and good tissue biocompatibility. This study develops exosome neurointerventional stent coating as a bioactive drug via reactive oxygen species accumulation in lesions, thus targeting drug release, inhibiting intimal hyperplasia, and reducing inflammation and thrombosis.

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Thromboresistant semi-IPN hydrogel coating: Towards improvement of the hemocompatibility/biocompatibility of metallic stent implants

Cited by 30 publications

References 75 publications

Osteoporotic Bone Recovery by a Highly Bone‐Inductive Calcium Phosphate Polymer‐Induced Liquid‐Precursor

Osteoporotic Bone Recovery by a Highly Bone‐Inductive Calcium Phosphate Polymer‐Induced Liquid‐Precursor

Multipronged Approach to Combat Catheter-Associated Infections and Thrombosis by Combining Nitric Oxide and a Polyzwitterion: a 7 Day In Vivo Study in a Rabbit Model

Preparation of ROS‐Responsive Exosome Coating of Nitinol Material for Making the Neurointerventional Stent

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