Thrombose intracardiaque au cours d’une maladie cœliaque

Jaafoura, Neirouz Ghannouchi; Atig, A.; Bouker, A.; Alaoua, O.; Jazia, E. Ben; Khalifa, M.; Bahri, F.

doi:10.1016/j.jmv.2013.12.002

Cited by 5 publications

(7 citation statements)

References 21 publications

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“…Other authors described in CD changes such as endothelial dysfunction, platelets impairment, increased apoptosis and exposure of phospholipids [51]. Therefore, positive antiphospholipids antibodies could be found [77,78,80].…”

Section: Discussionmentioning

confidence: 89%

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Hemorrhagic Events in Adult Celiac Disease Patients. Case Report and Review of the Literature

Dima

Jurcuţ²,

Manolache³

et al. 2018

JGLD

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Background & Aims: Celiac disease (CD) presents with a wide spectrum of extra-digestive symptoms, including hemorrhagic manifestations. The aim of this review was to conduct an extensive analysis of the hemorrhagic events reported in adult CD patients.Methods: Case report and review of the literature. Pubmed (MEDLINE) database search from January 1970 onwards was performed using the medical subject headings [MeSH] terms “celiac disease” AND “blood coagulation disorders”, “hemorrhage”, “hematoma”, “hematuria”, “hemoptysis”, “epistaxis”, “hemosiderosis”.Only case reports were identified on the search theme. Information on patients’ characteristics, diagnostic features, coagulation parameters, symptomatology duration, and evolution under treatment were systematically collected and summarized.Results: We present the case of a 40-year-old man hospitalized for spontaneous muscular hematomas, in whom CD was diagnosed. We performed a review of the literature and summarized the published case reports of 46 CD patients, aged between 19 and 74 years, 64% of male gender. In 25% of cases, the symptomatology was present for more than 5 years prior to CD diagnosis. The clinical hemorrhagic events were as follows: 15 patients had gastrointestinal bleeding, 9 hemoptysis, 4 epistaxis, 6 hematuria, 8 cutaneous hematoma, petechia or ecchymoses, and only in 1 case hemarthrosis, hemorrhagic vesicular dermatitis, subcortical hemorrhage, or adrenal hemorrhage. Sixty percent of the patients had digestive symptoms, while the rest had only extradigestive CD involvement. The Lane Hamilton syndrome was defined in 15 patients. The evolution under a gluten-free diet was favorable in most cases.Conclusion: This review of case reports aims to increase awareness to hemorrhagic events, rare but possible life-threatening conditions, as part of the CD clinical spectrum. To the best of our knowledge, this is the first review of all types of hemorrhagic events in adult CD patients.

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Section: Discussionmentioning

confidence: 89%

“…However, a procoagulant state might characterize the CD clinical appearance. The hepatic production of the proteins C and S is also vitamin K dependent [76][77][78]. Moreover, folate deficiency could be found in CD patients due to protein loss [39] with subsequent hyperhomocysteinaemia [76,77].…”

Section: Discussionmentioning

confidence: 99%

Hemorrhagic Events in Adult Celiac Disease Patients. Case Report and Review of the Literature

Dima

Jurcuţ²,

Manolache³

et al. 2018

JGLD

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“…A brief description of published cases reporting such association in the literature is summarized in Table 1 [ 2 , 8 , 10 – 18 ].…”

Section: Discussionmentioning

confidence: 99%

“…et al Hyperhomocysteinemia and Antiphospholipid antibodes, protein S deficiency SVT 2 cases Female ( n = 2) 63, 19 [ 17 ] 2013 Ghannouchi. et al Protein S and C deficiency Intracardiac thrombosis 1 case Male, 32 [ 2 ] 2016 Wassim. et al Protein C and S deficiency Retinal central vein 1 case Female, 26 [ 18 ] SVT Cerebral sinus venous thrombosis, SMA Superior mesenteric artery, MCA Middle cerebral artery, DVT Deep vein thrombosis …”

Section: Discussionmentioning

confidence: 99%

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Concurrent cerebral arterial and venous sinus thrombosis revealing celiac disease- a case report and literature review

Alhosain

Kouba

2020

BMC Gastroenterol

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Background Celiac disease is an autoimmune condition characterized by an inappropriate immune reaction against gluten. It classically presents as chronic diarrhea, bloating, and nausea in addition to malabsorption symptoms such as weight loss and micronutrient deficiency. We report the first case of coinciding cerebral infarction and venous sinus thrombosis unveiling the diagnosis of celiac disease. Case presentation A 40-year old female patient with a four-day history of severe diarrhea presented with right hemiplegia and altered mental status. Imaging revealed left middle cerebral artery occlusion and left transverse and sigmoid venous sinus thrombosis, along with left jugular vein thrombosis. Her laboratory evaluation was notable for profound iron deficiency anemia, thrombocytosis, and hyperhomocysteinemia. Her positive anti-tissue transglutaminase IgA antibodies and ensuing duodenal biopsy confirmed the diagnosis of celiac disease. Conclusions Celiac disease has a wide range of intestinal and extraintestinal manifestations and can present with thrombotic events in young patients with iron deficiency and hyperhomocysteinemia.

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Thromboembolic complications and cardiovascular events associated with celiac disease

et al. 2020

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Thrombose intracardiaque au cours d’une maladie cœliaque

Cited by 5 publications

References 21 publications

Hemorrhagic Events in Adult Celiac Disease Patients. Case Report and Review of the Literature

Hemorrhagic Events in Adult Celiac Disease Patients. Case Report and Review of the Literature

Concurrent cerebral arterial and venous sinus thrombosis revealing celiac disease- a case report and literature review

Thromboembolic complications and cardiovascular events associated with celiac disease

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