Thromboseprophylaxe in der muskuloskelettalen Chirurgie

Pabinger‐Fasching, Ingrid; Eichinger-Hasenauer, Sabine; Grohs, Josef G.; Hochreiter, Josef; Kastner, Norbert; Korninger, Hans Christian; Kozek‐Langenecker, Sibylle A.; Marlovits, Stefan; Niessner, H; Rachbauer, Franz; Ritschl, Peter; Wurnig, Christian; Windhager, Reinhard

doi:10.1007/s00508-014-0509-5

Cited by 3 publications

(2 citation statements)

References 63 publications

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“…The decision for or against a bridging therapy with appropriate doses of anticoagulants depends on assessment of the risk of thrombosis against the risk of bleeding. 28 In our study, 31 patients in the test group (6 patients with DVT, 25 patients with PE) and 33 patients in the control group received bridging therapy. Inadequate prophylaxis significantly increased the likelihood of both DVT (P ¼ .002) and PE (P ¼ .007).…”

Section: Discussionmentioning

confidence: 94%

“…The appropriateness of VTE prophylaxis was evaluated using the Caprini score. 14,27,28 We evaluated the adequacy of dose, the dosing interval, and the appropriate duration of therapy based on the risk assessment score provided by the guidelines. 14 We also reviewed the proper dosage and dosing interval of low-molecular-weight heparins and the accompanying diagnosis.…”

Section: Resultsmentioning

confidence: 99%

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Influence of Prescribed Blood Products on the Incidence of Deep Vein Thrombosis and Pulmonary Embolism in Surgical Patients

Marušič

Locatelli

Mrhar

et al. 2017

Clin Appl Thromb Hemost

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Deep vein thrombosis (DVT) and pulmonary embolisms (PEs) are common complications after surgical procedures. The influence of prescribed blood products on the occurrence of DVT and PE was evaluated in postsurgical patients in this retrospective case-control study. The records of 286 surgical patients were analyzed: DVT (n = 52), PE (n = 92), and a control group (n = 142). The amounts of prescribed blood, blood products, and vitamin K were reviewed, together with appropriate prescribing of low-molecular-weight heparins. The influence of prescribed blood products on the occurrence of DVT or PE was analyzed using multinomial logistic regression. We demonstrated a significant difference between the test and control groups ( P < .05) in relation to receiving packed red blood cells. Treatment with red blood cells was associated with an increased risk of PE but not DVT. Patients who developed PE after surgery were hospitalized for longer (median 10 days) than patients with DVT (median 6 days). There was no difference between the test and control groups concerning treatment with fresh frozen plasma. Inadequate thromboprophylaxis significantly increased the likelihood of DVT. There is a connection between receiving packed red blood cells and occurrence of postoperative PE in surgical patients. Thus, patients receiving red blood cells should be monitored more closely after surgery, as they are more likely to develop PE postoperatively.

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Section: Discussionmentioning

confidence: 94%

Section: Resultsmentioning

confidence: 99%

Influence of Prescribed Blood Products on the Incidence of Deep Vein Thrombosis and Pulmonary Embolism in Surgical Patients

Marušič

Locatelli

Mrhar

et al. 2017

Clin Appl Thromb Hemost

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Behandlung der traumatisch eröffneten Bursa praepatellaris

Kaiser

Schmidle

Raas

et al. 2015

Oper Orthop Traumatol

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Detection of targets and their mechanisms for early diagnosis of traumatic deep vein thrombosis

Jw¹,

Df²,

Gl³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. The purpose of this investigation was to identify targets for the early diagnosis and predictors of deep venous thrombosis (DVT) and the role of these targets in the formation of venous thrombosis. A model of DVT was constructed in rats. Thromboses and venous walls were sampled for reverse transcription polymerase chain reaction study, and blood was sampled for enzyme-linked immunosorbent assay studies. Vein endothelial cells were cultured to observe the effects of interleukin (IL)-17 on the expression of tissue plasminogen activator (t-PA)/plasminogen activator inhibitor type 1 (PAI-1). IL-17 monoclonal antibody was used to study its effect on preventing the formation of DVT. One-hundred and twenty hours after the animal model was constructed, significant DVT started to form. Polymerase chain reaction tests showed that immediately after the model was created, the expression of IL-17 increased greatly, whereas the balance between t-PA and PAI-1 was disrupted just before DVT formed. The increase of serum IL-17 was positively related with the formation of DVT. Thus, the application of IL-17 monoclonal antibody could reduce the formation of DVT in J.W. Mo et al. 2414©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (1): 2413-2421 (2015) rats. IL-17 might be a target for the early diagnosis of DVT and should be further studied to assess its clinical value.

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Thromboseprophylaxe in der muskuloskelettalen Chirurgie

Cited by 3 publications

References 63 publications

Influence of Prescribed Blood Products on the Incidence of Deep Vein Thrombosis and Pulmonary Embolism in Surgical Patients

Influence of Prescribed Blood Products on the Incidence of Deep Vein Thrombosis and Pulmonary Embolism in Surgical Patients

Behandlung der traumatisch eröffneten Bursa praepatellaris

Detection of targets and their mechanisms for early diagnosis of traumatic deep vein thrombosis

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