Thrombosis

Abstract

Background— Thrombosis is the common pathology underlying ischemic heart disease, ischemic stroke, and venous thromboembolism (VTE). The Global Burden of Disease Study 2010 (GBD 2010) documented that ischemic heart disease and stroke collectively caused 1 in 4 deaths worldwide. GBD 2010 did not report data for VTE as a cause of death and disability. Objective— To review the literature on the global burden of disease caused by VTE. Approach and Results— We performed a systematic review of the literature on the global disease burden because of VTE in low-, middle-, and high-income countries. Studies from Western Europe, North America, Australia, and Southern Latin America (Argentina) yielded consistent results with annual incidences ranging from 0.75 to 2.69 per 1000 individuals in the population. The incidence increased to between 2 and 7 per 1000 among those aged ≥70 years. Although the incidence is lower in individuals of Chinese and Korean ethnicity, their disease burden is not low because of population aging. VTE associated with hospitalization was the leading cause of disability-adjusted life-years lost in low- and middle-income countries, and second in high-income countries, responsible for more disability-adjusted life-years lost than nosocomial pneumonia, catheter-related blood stream infections, and adverse drug events. Conclusions— VTE causes a major burden of disease across low-, middle-, and high-income countries. More detailed data on the global burden of VTE should be obtained to inform policy and resource allocation in health systems and to evaluate whether improved use of preventive measures will reduce the burden.

High Burden of 30‐Day Readmissions After Acute Venous Thromboembolism in the United States

“…Acute VTE is a major public health problem, with an incidence that is steadily increasing because of the aging population, increasing rates of comorbid conditions associated with VTE (eg, obesity and malignancy), and improved detection on imaging studies 1, 20. This disease process is also complex, involving the interaction between acquired and inherited predispositions for thrombosis.…”

“…This disease process is also complex, involving the interaction between acquired and inherited predispositions for thrombosis. Many of these factors are related to external causes, such as hospitalization for surgery or trauma, pregnancy, prolonged immobilization, and active malignancy 1. This heterogeneity in presentation and risk factors makes caring for these patients challenging and has prompted the development of formalized, multifaceted, team‐based approaches 21…”

“…With nearly 10 million annual cases worldwide and an individual lifetime risk of >8%, VTE represents the third leading cause of vascular disease 1, 2, 3. VTE is associated with significant morbidity and mortality, accounting for >200 000 deaths in the United States annually 4.…”

Protective effect of breviscapine in acute pulmonary embolism rats via regulation ofMCP‐1 andIL‐13

“…Pulmonary embolism (PE) is a blockage of an artery in the lungs by a substance that has travelled from elsewhere in the body through the bloodstream,1 which results in between 50 000 and 200 000 deaths in United States every year 2…”

Polymorphisms in PARK2 and MRPL37 are associated with higher risk of recurrent venous thromboembolism in a sex-specific manner

“…(CVD) [1]. In Europe, the annual incidence of VTE is 1-2 per 1000 people with over half a million deaths annually attributed to VTE [2,3].…”