Thrombosis and cancer

Oncogenes and the coagulation system – forces that modulate dormant and aggressive states in cancer

“…Evidence to this effect includes the role of clotting factors and platelets in such fundamental processes in cancer as cellular growth, angiogenesis, metastasis, inflammation, therapeutic responsiveness and vascular comorbidities, as extensively reviewed in the recent literature [6,7,20,21,25,[84][85][86][87][88][89][90][91]. Notably, pharmacological and genetic strategies targeting TF, FVIIa, thrombin, platelets and other coagulation mechanisms led to anti-tumor and anti-metastatic effects [61,[92][93][94][95][96], which are often comparable to other 'main stream' targeted agents [87,93].…”

Varicose veins: Look before you strip – the occluded inferior vena cava and other lurking pathologies

“…Thrombosis in cancer results from the hypercoagulability associated with malignancy and/or local compression or infiltration of veins. [5] Both these mechanisms were probably operative in this patient.…”

Safety and Efficacy of Peripherally Inserted Central Catheters in Terminally Ill Cancer Patients: Single Institute Experience

“…Despite the lack of the cancer specific data, current guidelines recommend thromboprophyaxis for hospitalized patients with cancer according to risk stratification of VTE (Venous Thromboembolism) (19). On the other hand, whether a thromboprophylaxis is needed for cancer outpatients with CVC is a controversial status.…”