Thrombosis and Coagulopathy in COVID-19

Mesa, Juan E.; Galindo-Coral, Stephania; Montes, María Claudia; Martín, Andrés J. Muñoz

doi:10.1016/j.cpcardiol.2020.100742

Cited by 231 publications

(278 citation statements)

References 26 publications

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“…To note, in contrast to the few studies taken place in our working environment, none of the patients we present with concomitant COVID-19 infection required invasive oxygen therapy. This observation makes an important difference in contrast to other cases reported, which show clear correlation [10,11].…”

Section: Discussioncontrasting

confidence: 91%

Arterial thrombosis, the unfairly forgotten actor in COVID-19: a case series

Cillán

Blanco

Mallebrera

et al. 2021

Preprint

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Background. - It is known that patients with COVID-19 are at increased risk of thrombosis. Although COVID-19 infection primarily affects the lower respiratory tract system, emerging reports suggest direct and indirect cardiovascular complications. However, the key mechanisms under thrombosis development at great arterial vessels are still unclear.Case presentation. – We report the cases of 4 patients who were admitted to our hospital and suffered from arterial thrombotic complications. All of them were older than 60 years and only 1 did not have cardiovascular risk factors. It should be noted that days prior to the diagnosis of arterial thrombosis, 3 of the 4 patients were under anticoagulant treatment. It is also interesting that in contrast to already known typical microvascular locations, our patients suffered from large arterial vessels thrombosis. Furthermore, none of them would present with severe respiratory symptoms. Conclusions. – The underlying mechanism of COVID-19-associated arterial thrombosis remains unclear and might be independent of the cytokine storm that occurs in patients with COVID-19-associated venous thrombosis. Also, the role of anti-platelets agents as prophylactic treatment in high-risk patients remains unclear. Multicenter clinical trials are necessary to clarify these issues.

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Section: Discussioncontrasting

confidence: 91%

Arterial thrombosis, the unfairly forgotten actor in COVID-19: a case series

Cillán

Blanco

Mallebrera

et al. 2021

Preprint

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“…6 COVID-19-associated coagulopathy may lead to stroke, deep venous thrombosis, or pulmonary embolism. 7,8 Clinicians must be able to consider all the potential causes of worsening respiratory symptoms in this patient population. These situations emphasize the importance of keeping a broad differential diagnosis, which has become even more crucial in the COVID-19 pandemic.…”

Section: Discussion Pointsmentioning

confidence: 99%

Chronic Obstructive Pulmonary Disease in the Emergency Department: What Are We Missing?

Freeman

Ritter

Barrett

2021

Annals of Emergency Medicine

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“…Evidence suggests a protective role of Vit D against the development of SARS-COV-2 infection and severity of COVID-19 (McCartney et al 1971 ). In a systematic review and meta-analyses on the impact of hypovitaminosis D on COVID-19 patients, Pereira et al reported that in terms of disease severity, patients with severe COVID-19 presented with hypovitaminosis D 65% more than patients with mild disease.…”

Section: Current Connections Between Vitamin D Covid-19 Respiratory Viral Infections and Latitudementioning

confidence: 99%

Shedding light on vitamin D: the shared mechanistic and pathophysiological role between hypovitaminosis D and COVID-19 risk factors and complications

Menshawey

Nabeh

2021

Inflammopharmacol

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Severe acute respiratory syndrome coronavirus (SARS-COV-2) is the culprit of the Coronavirus Disease (COVID-19), which has infected approximately 173 million people and killed more than 3.73 million. At risk groups including diabetic and obese patients are more vulnerable to COVID-19-related complications and poor outcomes. Substantial evidence points to hypovitaminosis D as a risk factor for severe disease, the need for ICU, and mortality. 1,25(OH)D, a key regulator of calcium homeostasis, is believed to have various immune-regulatory roles including; promoting anti-inflammatory cytokines, down regulating pro-inflammatory cytokines, dampening entry and replication of SARS-COV-2, and the production of antimicrobial peptides. In addition, there are strong connections which suggest that dysregulated 1,25(OH)D levels play a mechanistic and pathophysiologic role in several disease processes that are shared with COVID-19 including: diabetes, obesity, acute respiratory distress syndrome (ARDS), cytokine storm, and even hypercoagulable states. With evidence continuing to grow for the case that low vitamin D status is a risk factor for COVID-19 disease and poor outcomes, there is a need now to address the public health efforts set in place to minimize infection, such as lock down orders, which may have inadvertently increased hypovitaminosis D in the general population and those already at risk (elderly, obese, and disabled). Moreover, there is a need to address the implications of this evidence and how we may apply the use of cheaply available supplementation, which has yet to overcome the near global concern of hypovitaminosis D. In our review, we exhaustively scope these shared pathophysiologic connections between COVID-19 and hypovitaminosis D.

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Thrombosis and Coagulopathy in COVID-19

Cited by 231 publications

References 26 publications

Arterial thrombosis, the unfairly forgotten actor in COVID-19: a case series

Arterial thrombosis, the unfairly forgotten actor in COVID-19: a case series

Chronic Obstructive Pulmonary Disease in the Emergency Department: What Are We Missing?

Shedding light on vitamin D: the shared mechanistic and pathophysiological role between hypovitaminosis D and COVID-19 risk factors and complications

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