Thrombosis in antithrombin-III-deficient persons. Report of a large kindred and literature review

Demers, Christine; Ginsberg, Jeff; Hirsh, Joseph; Henderson, Penny; Blajchman, Morris A.

doi:10.1016/0020-7292(93)90238-r

Cited by 38 publications

(47 citation statements)

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“…The mean prevalence of venous thromboembolism among heterozygous subjects was 51% compared with controls without the deficiency (1.5%). 5 The incidence of the disorder in the general population is estimated at 1 in 2000 to 5000. 6,7 AT deficiency is classified into 2 types.…”

Section: Introductionmentioning

confidence: 99%

Impact of antithrombin deficiency in thrombogenesis: lipopolysaccharide and stress-induced thrombus formation in heterozygous antithrombin-deficient mice

Yanada

Kojima

Ishiguro

et al. 2002

Blood

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Section: Introductionmentioning

confidence: 99%

Impact of antithrombin deficiency in thrombogenesis: lipopolysaccharide and stress-induced thrombus formation in heterozygous antithrombin-deficient mice

Yanada

Kojima

Ishiguro

et al. 2002

Blood

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“…55 Generally, these deficiencies appear to increase risk about 10-fold in heterozygotes. 54,56,57 Most clinicians feel that antithrombin deficiency carries a higher risk than PC or PS deficiency. The exceedingly rare homozygous deficiency of a natural anticoagulant results in a pronounced thrombotic tendency with widespread thrombosis (purpura fulminans) occurring shortly after birth.…”

Section: Deficiencies Of Natural Coagulation Inhibitorsmentioning

confidence: 99%

Hypercoagulability: Too Many Tests, Too Much Conflicting Data

Bauer¹,

Rosendaal²,

Heit³

2002

Hematology

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It is now possible to identify hereditary and acquired risk factors in a substantial percentage of patients presenting with a venous thrombotic event. The clinician is faced with an ever-growing number of laboratory tests that can be ordered in such patients, and there is considerable uncertainty as to how this information should be utilized in patient management. Some have argued that widespread testing of thrombosis patients for prothrombotic abnormalities such as the factor V Leiden and prothrombin G20210A mutations has been prematurely adopted into clinical practice as there are few data that their identification leads to improved clinical outcomes.Dr. Rosendaal provides an overview of the epidemiology of venous thrombosis with an emphasis on hereditary and acquired risk factors. The presentation will include information obtained from properly designed case-control studies as well as family studies.While some have suggested treatment strategies for managing patients with hereditary thrombophilia with prior thrombotic events or for managing patients undergoing procedures associated with increased thrombotic risk, clinical decision making is complicated by the need to assess the risk of recurrence and the likely benefit of prolonged anticoagulation versus the associated bleeding risk. Drs. Bauer, Heit, and Rosendaal discuss their approaches to patient management. Case presentations are used to illustrate the impact of laboratory test results on decisions.

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“…Thrombophilia, behcet ̓ s syndrome, myeloproliferative disorder, hepatic failure with transient antithrombin deficiency, acquired or congenital deficiency of protein C or ATIII and hepatocellular carcinoma are the most frequent causes of RAT (7,8). ATIIID is classified into acquired and congenital types.…”

Section: Discussionmentioning

confidence: 99%

Congenital Antithrombin Deficiency in a Pregnant Woman with Right Atrium Thrombosis

Sabzi

Khosravi

Faraji

2015

Ethiop J Health Sci

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Thrombosis in antithrombin-III-deficient persons. Report of a large kindred and literature review

Cited by 38 publications

References 0 publications

Impact of antithrombin deficiency in thrombogenesis: lipopolysaccharide and stress-induced thrombus formation in heterozygous antithrombin-deficient mice

Impact of antithrombin deficiency in thrombogenesis: lipopolysaccharide and stress-induced thrombus formation in heterozygous antithrombin-deficient mice

Hypercoagulability: Too Many Tests, Too Much Conflicting Data

Congenital Antithrombin Deficiency in a Pregnant Woman with Right Atrium Thrombosis

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