Thrombosis risk factors and gene mutations in young age patients with acute coronary syndrome

Abstract

Goal of research. Study the role of thrombosis risk factors and polymorphisms in genes in young age patients with acute coronary syndrome (ACS).Materials and methods. Te study included 299 patients of age 25 to 44 years old with ACS were treated from 2012 to 2017 at the department of myocardial infarction 1st KGBUZ Altay regional cardiological clinic. Te middle age of patients with ACS was 40.3 ± 0.2 years. Te control group included of 53 apparently healthy volunteers aged from 25 to 44 years old, the average age those patients was 39.94 ± 0.79 years. Also, those patients hadn’t any comorbid conditions. Te control group hadn’t any datas of ischemic heart disease by the results of exercise tolerance tests. All patients had standard clinical, anamnestic, biochemical tests, lipid profle, fasting plasma glucose, electrocardiogram, echocardiography and coronaroangiography, also they were determined growth and weight with body-weight index. 116 patients from the ACS group and 53 patients fromthe control group had screening of polymerase chain reaction for determine polymorphism of the FII genes G20210-A, FV G1691-A, and MTHFR C677-T.Results. We identifed the most signifcant sets of risk factors associated with ACS in young age patients based on our multifactorial statistical analysis with binary logistic regression. Tis combination of risk factors was: increased levels of low-density lipoproteins, decreased levels of high-density lipoproteins, smoking, existence of MTHFR homozygous polymorphism, heredity in combination with smoking, FV homozygote, MTHFR homozygote, smoking with MTHFR-homozygote.Conclusion. Te ability predicting the risk of developing cardiovascular disease in young people based on traditional risk factors, partly modifable, as well as the researching of "new" risk factors, opens up new opportunities for developing a clinical approach of treating young patients with high risk of ACS.

Equation with Many Unknowns in a Young Patient with Massive Coronary Thrombus

“…Ponomarenko and Sukmanova 14 demonstrated that smoking and the presence of polymorphism in MTHFR were defined as significant risk factors for ACS at an early age. The C677T polymorphism of MTHFR results in elevated plasma homocysteine levels in homozygous mutated individuals and inhibition of the MTHFR enzyme to catalyze the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate 15 Individuals with homozygous mutation have higher homocysteine levels than heterozygous mutation.…”

Association of the methylenetetrahydrofolate reductase (MTHFR) gene variant C677T with serum homocysteine levels and the severity of ischaemic stroke: a case–control study in the southwest of China

“…35 A previous study demonstrated that the MTHFR C677T polymorphism, in conjunction with traditional risk factors such as LDL-C, HDL-C and smoking, was a risk factor for atherosclerosis. 36 The C667T polymorphism in the MTHFR gene influences carotid atherosclerosis pathogenesis by destroying endothelial cells and promoting smooth muscle cell proliferation. 37 In addition, a link has been found between plasma Hcy, the MTHFR C677T gene polymorphism and carotid intimal thickness in South Asian, Chinese and European Canadians.…”

Expression of the C677T Polymorphism of the 5, 10-Methylenetetrahydrofolate Reductase (MTHFR) Gene in Patients with Carotid Artery Atherosclerosis

“…McNulty et al [ 26 ] showed that MTHFR 677C> T can increase the risk of hypertension by between 24% to 87%, and the authors showed that vitamin B2 supplementation had a better therapeutic effect on hypertensive patients with the MTHFR 677TT genotype. Ponomarenko et al [ 27 ] showed that MTHFR C677T polymorphism was a new risk factor for atherosclerosis, in addition to traditional risk factors such as LDL-C, HDL-C, and smoking.…”