Thrombosis Treatment and Prevention With Methylene-Bis-(Hydroxycoumarin)

Lehmann, Jörgen

doi:10.1016/s0140-6736(00)43039-4

Cited by 35 publications

(9 citation statements)

References 2 publications

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“…Both oral anticoagulants and heparin have been used in full therapeutic doses for almost 40 years to prevent venous thrombosis and pulmonary embolism in high risk patients [4,38,50,51,109,127,128,199]. The early experience was mainly with heparin given by intermittent intravenous injection [50,51,199] or continuous intravenous infusion [127,128].…”

Section: Anticoagulant Prophylaxismentioning

confidence: 99%

Prevention of Venous Thromboembolism

Gallus¹,

Hirsh²

2008

Semin Thromb Hemost

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Section: Anticoagulant Prophylaxismentioning

confidence: 99%

Prevention of Venous Thromboembolism

Gallus¹,

Hirsh²

2008

Semin Thromb Hemost

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“…The derivatives of coumarin specially biscoumarins have many properties and are widely used as anticoagulants, antitumor, antibiotic, anti‐HIV, urease inhibitors, antipyretics and human therapeutics, antithrombotic agent, cosmetics and in food industries …”

Section: Introductionmentioning

confidence: 99%

Sustainable and Eco‐Friendly Method for the Synthesis of Some Bioactive Derivatives of Biscoumarin and Pyrano[3,2‐c]Chromene‐3‐Carbonitrile Using Taurine, as the Catalyst

et al. 2019

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Coumarin is a bio‐organic compound which exists in some plants. Coumarin by its own or its derivatives are important compounds in the medicinal chemistry, agrochemistry fragrance and food chemistry. Bis(4‐hydroxycoumarin) derivatives are the most famous species of these compounds. Also, pyrano[3,2‐c]chromene‐3‐carbonitrile derivatives which contain a moiety of 4‐hydroxycoumarin have a wide range of biological activities. Taurine, the semi‐essential β‐amino acid in the organs of living creatures especially human and animals, is used as a green bio‐organic catalyst to promote the formation of biscoumarin and pyrano[3,2‐c]chromene‐3‐carbonitrile derivatives via a Knoevenagel‐Micheal reaction in aqueous media. Using this method, the requested products are obtained in high yields during acceptable reaction times and the catalyst can be recycled with high efficiency. In fact, in this study, a bio‐organic reagent is used as the catalyst to promote the synthesis of bioactive compounds in the greenest conditions possible.

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“…The compound 3,3 ′ -methylene-bis-4-hydroxycoumarin, commonly known as dicoumarol, occurs naturally in moldy clover 11 . It is the hemorrhagic agent responsible for the sweet clover disease of cattle and has also been employed for the prevention and treatment of thrombosis 12 . 3,3'-Arylmethylene-bis-4-hydroxycoumarins (3) are usually synthesized by condensing 4-hydroxycoumarin (1) with various aldehydes (aromatic, heterocyclic and α,β-unsaturated) (2) using different catalysts and media [8][9][10][13][14][15][16][17][18][19] .…”

Section: Introductionmentioning

confidence: 99%